Q95LA0

PR
Gene name
FATE1 (FATE)
Protein name
Fetal and adult testis-expressed transcript protein homolog
Names
Species
Bos taurus (Bovine)
KEGG Pathway
bta:281153
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

51-135 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q95LA0

Entry ID Method Resolution Chain Position Source
AF-Q95LA0-F1 Predicted AlphaFoldDB

32 variants for Q95LA0

Variant ID(s) Position Change Description Diseaes Association Provenance
rs443543350 17 K>N No EVA
rs451969683 20 D>A No EVA
rs440833497 25 S>T No EVA
rs478968637 29 N>K No EVA
rs443023486 31 E>Q No EVA
rs459731159 55 V>G No EVA
rs132805192 60 V>G No EVA
rs473961577 83 V>G No EVA
rs719197908 83 V>I No EVA
rs444228688 86 V>M No EVA
rs462789182 88 E>G No EVA
rs471689416 91 D>G No EVA
rs438754115 92 G>A No EVA
rs137065713 95 Q>P No EVA
rs448857596 101 G>R No EVA
rs482825826 103 S>F No EVA
rs469458164 104 Q>H No EVA
rs450980301 104 Q>P No EVA
rs433444899 106 M>T No EVA
rs445514905 107 R>T No EVA
rs466884147 108 S>A No EVA
rs433994503 110 F>V No EVA
rs455721386 111 E>G No EVA
rs439922249 112 R>C No EVA
rs460744241 114 E>G No EVA
rs443064372 131 M>I No EVA
rs461631943 132 E>K No EVA
rs482980682 132 E>V No EVA
rs450088032 133 I>V No EVA
rs458958107 136 R>G No EVA
rs453589856 140 M>L No EVA
rs474980334 160 V>G No EVA

No associated diseases with Q95LA0

No regional properties for Q95LA0

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q95LA0

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion
  • Mitochondrion outer membrane
  • Endoplasmic reticulum membrane ; Single-pass membrane protein ; Cytoplasmic side
  • Localized to specific membrane structures termed mitochondria-associated membranes (MAMs) which connect the endoplasmic reticulum (ER) and the mitochondria
  • Also associated with the outer surface of mitochondria at sites that are not in close contact with the ER
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondria-associated endoplasmic reticulum membrane A zone of apposition between endoplasmic-reticulum and mitochondrial membranes, structured by bridging complexes. These contact sites are thought to facilitate inter-organelle calcium and phospholipid exchange.
mitochondrial outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.

1 GO annotations of molecular function

Name Definition
ubiquitin protein ligase binding Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins.

3 GO annotations of biological process

Name Definition
apoptotic process A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
negative regulation of apoptotic process Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
negative regulation of mitochondrial calcium ion concentration Any process that decreases the concentration of calcium ions in mitochondria.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAGGAVPNLK EKMQVPKDED LLLGSFRDNQ ECSVAAEMKE HMSRLLGASQ RRQRVDPKAV
70 80 90 100 110 120
GSAVVWNTAA NQSKKMGPQL RGVGVVGEQG DGGAQPQENP GGSQGMRSQF ERRELNTLAE
130 140 150 160 170
IGLEELNELE MEIMRRQLFM ITERLRYLED QSATWHQREV LLFTMLLSSC ITNLWLWMRQ