Q95KH6

PR
Gene name
RASGEF1C (QtrA-12086)
Protein name
Ras-GEF domain-containing family member 1C
Names
Species
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-64 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q95KH6

Entry ID Method Resolution Chain Position Source
AF-Q95KH6-F1 Predicted AlphaFoldDB

No variants for Q95KH6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q95KH6

No associated diseases with Q95KH6

3 regional properties for Q95KH6

Type Name Position InterPro Accession
domain Ras-like guanine nucleotide exchange factor, N-terminal 34 - 164 IPR000651
domain Ras guanine-nucleotide exchange factors catalytic domain 196 - 447 IPR001895
conserved_site Ras guanine-nucleotide exchange factor, conserved site 364 - 394 IPR019804

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

1 GO annotations of molecular function

Name Definition
guanyl-nucleotide exchange factor activity Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.

1 GO annotations of biological process

Name Definition
small GTPase mediated signal transduction The series of molecular signals in which a small monomeric GTPase relays a signal.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPQTLSASDM VTPGSLSPPT TEPTDGEQAG QPLLDGAPSS ASLETLIQHL VPTADYYPEK
70 80 90 100 110 120
AYIFTFLLSS RLFIEPRELL ARVCHLCIEQ QQLDKPVLDK ARVRKFGPKL LQLLAEWTET
130 140 150 160 170 180
FPRDFQEEST IGQLKDVVGR IAPCDETYRK RMHQLLQALH QKLAALRQGP EGLVSADKPI
190 200 210 220 230 240
SYRTKPPASI HRELLGVCSD PYTLAQQLTH VELERLRHIG PEEFVQAFVN KDPLASTKPC
250 260 270 280 290 300
FSDKTSHLEA YVKWFNRLCY LVATEICMPA KKKQRAQVIE FFIDVARECF NIGNFNSLMA
310 320 330 340 350 360
IISGMNMSPV SRLKKTWAKV KTAKFFILEH QMDPTGNFCN YRTALRGAAH RSLTAHSSRE
370 380 390 400 410 420
KIVIPFFSLL IKDIYFLNEG CANRLPNGHV NFEKFLELAK QVGEFITWKQ VECPFEQDPS
430 440 450 460
ITHYLSTAPI FSEDGLYLAS YESESPENQT EKERWKSLRS SILGKT