Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q95KE2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q95KE2-F1 | Predicted | AlphaFoldDB |
No variants for Q95KE2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q95KE2 | |||||
No associated diseases with Q95KE2
1 regional properties for Q95KE2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Amino acid transporter, transmembrane domain | 115 - 510 | IPR013057 |
Functions
10 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell surface | The external part of the cell wall and/or plasma membrane. |
| cell tip | The region at the end of the longest axis of a cylindrical or elongated cell. |
| cone cell pedicle | A specialized axon terminus which is produced by retinal cone cells. Pedicles are large, conical, flat end-feet (8-10 micrometers diameter) of the retinal cone axon that lie more or less side by side on the same plane at the outer edge of the outer plexiform layer (OPL). |
| cytoplasmic vesicle membrane | The lipid bilayer surrounding a cytoplasmic vesicle. |
| dendrite terminus | A structure at the distal end of a dendrite adapted to carry out a specific function, e.g. dendriole. |
| inhibitory synapse | A synapse in which an action potential in the presynaptic cell reduces the probability of an action potential occurring in the postsynaptic cell. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| presynapse | The part of a synapse that is part of the presynaptic cell. |
| presynaptic active zone | A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix. |
| synaptic vesicle | A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| gamma-aminobutyric acid transmembrane transporter activity | Enables the transfer of gamma-aminobutyric acid from one side of a membrane to the other. Gamma-aminobutyric acid is 4-aminobutyrate (GABA). |
| gamma-aminobutyric acid:proton antiporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4-aminobutanoate(out) + n H+(in) = 4-aminobutanoate(in) + n H+(out). |
| gamma-aminobutyric acid:proton symporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: gamma-aminobutyric acid(out) + H+(out) = gamma-aminobutyric acid(in) + H+(in). |
| glycine transmembrane transporter activity | Enables the transfer of glycine from one side of a membrane to the other. Glycine is aminoethanoic acid. |
| glycine:proton antiporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine(out) + n H(+)(in) = glycine(in) + n H(+)(out). |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| beta-alanine transport | The directed movement of beta-alanine, 3-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| gamma-aminobutyric acid import | The directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate) into a cell or organelle. |
| gamma-aminobutyric acid transport | The directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| glycine transport | The directed movement of glycine, aminoethanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| neurotransmitter transport | The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MATLLRSKLS | NVATSVSNKS | QAKVSGMFAR | MGFQAATDEE | AVGFAHCDDL | DFEHRQGLQM |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DILKAEGEPC | GDEGAEPPVE | GDIHYQRGSG | APLPPSGSKD | QVGAGGEFGG | HDKPKITAWE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AGWNVTNAIQ | GMFVLGLPYA | ILHGGYLGLF | LIIFAAVVCC | YTGKILIACL | YEENEDGEVV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RVRDSYVAIA | NACCAPRFPT | LGGRVVNVAQ | IIELVMTCIL | YVVVSGNLMY | NSFPGLPVSQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KSWSIIATAV | LLPCAFLKNL | KAVSKFSLLC | TLAHFVINIL | VIAYCLSRAR | DWAWEKVKFY |
| 310 | 320 | 330 | 340 | 350 | 360 |
| IDVKKFPISI | GIIVFSYTSQ | IFLPSLEGNM | QQPSEFHCMM | NWTHIAACVL | KGLFALVAYL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TWADETKEVI | TDNLPGSIRA | VVNIFLVAKA | LLSYPLPFFA | AVEVLEKSLF | QEGSRAFFPA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| CYGGDGRLKS | WGLTLRCALV | VFTLLMAIYV | PHFALLMGLT | GSLTGAGLCF | LLPSLFHLRL |
| 490 | 500 | 510 | 520 | ||
| LWRKLLWHQV | FFDVAIFVIG | GICSVSGFVH | SLEGLIEAYR | TNAED |