Q95JS1

PR
Gene name
PLCZ1
Protein name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
Names
Phosphoinositide phospholipase C-zeta-1, Phospholipase C-zeta-1, PLC-zeta-1
Species
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
KEGG Pathway
EC number
3.1.4.11: Phosphoric diester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

237-450 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q95JS1

Entry ID Method Resolution Chain Position Source
AF-Q95JS1-F1 Predicted AlphaFoldDB

No variants for Q95JS1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q95JS1

No associated diseases with Q95JS1

5 regional properties for Q95JS1

Type Name Position InterPro Accession
domain C2 domain 498 - 622 IPR000008
domain Phosphatidylinositol-specific phospholipase C, X domain 155 - 300 IPR000909
domain Phospholipase C, phosphatidylinositol-specific, Y domain 382 - 498 IPR001711
domain EF-hand domain 35 - 70 IPR002048
domain Phosphoinositide-specific phospholipase C, EF-hand-like domain 64 - 147 IPR015359

Functions

Description
EC Number 3.1.4.11 Phosphoric diester hydrolases
Subcellular Localization
  • Nucleus
  • Cytoplasm, perinuclear region
  • Exhibits alternative cytoplasmic/nuclear localization during development
  • Translocates from the pronucleus into cytoplasm upon nuclear envelope breakdown for mitosis and localizes again to the pronucleus at interphase following meiosis and mitosis (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.

2 GO annotations of molecular function

Name Definition
calcium ion binding Binding to a calcium ion (Ca2+).
phosphatidylinositol phospholipase C activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+).

4 GO annotations of biological process

Name Definition
calcium ion transport The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
egg activation The process in which the egg becomes metabolically active, initiates protein and DNA synthesis and undergoes structural changes to its cortex and/or cytoplasm.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
lipid catabolic process The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEMKWFLSKI QDDFRGGKIN LEKTQRLLEK LDIRCSYIHV KRIFKDNDRL KQGRITIEEF
70 80 90 100 110 120
RAIYRILTHR EEIVEIFNAY SENRKILLEN NLVQFLTQEQ YTTEMSKTIA FEIIQKYEPI
130 140 150 160 170 180
EEVRKARQMS LEGFTRYMDS RECQLFKNEC RKVYQDMTHP LNDYFISSSH NTYLVSDQLV
190 200 210 220 230 240
GPSDLWGYVS ALVKGCRCLE IDCWDGAQNE PVVYHGYTLT SKLLFKTVIQ AIHKYAFMTS
250 260 270 280 290 300
DYPVVLSLEN HCSPAQQEIM ADNLQTTFGE SLLSDMLADF PDTLPSPEAL KFKVLVKNKK
310 320 330 340 350 360
IGTLKETHER KGSDKRGKVE EWEEEVADLE EEEEEEEKFK ESEIFESVLG ENQDKETGVK
370 380 390 400 410 420
KLSGVTLFKK KKTRKLKIAL ALSDLVIYTK AEKFKSFQHS RLYQQFNENN SIGETQARKL
430 440 450 460 470 480
SKLRAHEFIF HTRKFITRIY PKATRADSSN FNPQEFWNIG CQMVALNFQT PGLPMDLQNG
490 500 510 520 530 540
KFLDNGGSGY ILKPHFLRES ESYFNPSDIK DSMPITLTIR LISGIQLPLT HSSSNKGDTL
550 560 570 580 590 600
VIIEVFGVPN DQMKQQTRVI KKNAFSPRWN ETFTFIIHVP ELALIRFVVE SQGLIAGNEF
610 620 630 640
LGQYTLPLLC MNKGYRRVPL FSRMGESLEP ASLFVYVWYV R