Q95JM8

PR
Gene name
DRC1 (CCDC164)
Protein name
Dynein regulatory complex protein 1
Names
Coiled-coil domain-containing protein 164
Species
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-220 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q95JM8

Entry ID Method Resolution Chain Position Source
AF-Q95JM8-F1 Predicted AlphaFoldDB

No variants for Q95JM8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q95JM8

No associated diseases with Q95JM8

2 regional properties for Q95JM8

Type Name Position InterPro Accession
domain Dynein regulatory complex protein 1, C-terminal 660 - 719 IPR029440
domain Dynein regulatory complex protein 1/2, N-terminal 100 - 200 IPR039505

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytoskeleton, cilium axoneme
  • Cytoplasm, cytoskeleton, flagellum axoneme
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
axonemal dynein complex A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion.
axoneme The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.
motile cilium A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

2 GO annotations of biological process

Name Definition
axonemal dynein complex assembly The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion.
cilium-dependent cell motility Cell motility due to the motion of one or more eukaryotic cilia. A eukaryotic cilium is a specialized organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNPPGSLAGL DPNLDEHLST QILAPSVHSD NPQERIQARR LRIAARLEPR RREALGEYLD
70 80 90 100 110 120
GKKESEEDQS KSYKQKEESR LKLAKLLLCG TELVTNIQVA IDIREIHRRV EEEEIKRQRI
130 140 150 160 170 180
EKLENEVKTS QDKFDEITSK WEEGKQKRIP QELWEMLNTQ QLHCAGLLED KNKLISELQQ
190 200 210 220 230 240
ELKTKDDQYV KDLKKQSDDI CLLLERMEEQ VKNVMKTFRE ELYNIEKAFE VERQELLASN
250 260 270 280 290 300
KKKWERALQA HNAKELEYLT NRMKKVEDYE KQLNRQRIWD CEEYNTIKIK LEQDVQILEQ
310 320 330 340 350 360
QLQQRKAIYQ LNQEKLEYNL QVLKKRDEES TVIKSQQKRK INRLHDILNN LRSKYAKQIK
370 380 390 400 410 420
QFQEENQSLT LDYKRLVLQF KELQKAMRHF ALIDDEKFRE IWLMNEEEAK DLIARAFDVD
430 440 450 460 470 480
RIIHTHHLGL PWTAPDFWFL KNVGPISQQP QKSATQIVEE MLMHTEEEEA EEAASEPESY
490 500 510 520 530 540
LDLPKQVSEK TTKKILMLLC DESGFLIESK LLSLLLPLEQ NECYLLRLDA IFSALGIESE
550 560 570 580 590 600
DDLYKLVNFF LKYRAHRLSS SLQIKSCSQA SMEKASMEET SMGSELELAE QTEMEGAKEE
610 620 630 640 650 660
SLVEGEKEEE EETPPSPWDI HPNDVLKILE AFVMGLKKPR DSRAPPRVQK NMRNNSKDSE
670 680 690 700 710 720
YWQALTTVIP SSKQNLWDAL YTALEKYHIV LTQRAKLLLE NSSLEQRNTE LQALLQQYLN
730
SKINSELQVP PTQVLRVPTK