Q95JH0

PR
Gene name
AGPAT1
Protein name
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha
Names
1-acylglycerol-3-phosphate O-acyltransferase 1, 1-AGP acyltransferase 1, 1-AGPAT 1, Lysophosphatidic acid acyltransferase alpha, LPAAT-alpha
Species
Ovis aries (Sheep)
KEGG Pathway
EC number
2.3.1.51: Transferring groups other than amino-acyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

237-287 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q95JH0

Entry ID Method Resolution Chain Position Source
AF-Q95JH0-F1 Predicted AlphaFoldDB

No variants for Q95JH0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q95JH0

No associated diseases with Q95JH0

2 regional properties for Q95JH0

Type Name Position InterPro Accession
domain Phospholipid/glycerol acyltransferase 83 - 213 IPR002123
domain 1-acyl-sn-glycerol-3-phosphate acyltransferase 81 - 210 IPR004552

Functions

Description
EC Number 2.3.1.51 Transferring groups other than amino-acyl groups
Subcellular Localization
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

1 GO annotations of molecular function

Name Definition
1-acylglycerol-3-phosphate O-acyltransferase activity Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate.

1 GO annotations of biological process

Name Definition
CDP-diacylglycerol biosynthetic process The chemical reactions and pathways resulting in the formation of CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MELWPGAGTL LLLLFLLLLL LLPTLWFCSP SAKYFFKMAF YNGWILFLAV LAIPVCAVRG
70 80 90 100 110 120
RNVENMKILR LMLLHIKYLY GIRVEVRGAH HFPPSQPYVV VSNHQSSLDL LGMMEVLPGH
130 140 150 160 170 180
CVPIAKRELL WAGSAGLACW LAGVIFIDRK RTGDAISVMS EVAQTLLTQD VRVWVFPEGT
190 200 210 220 230 240
RNHNGSMLPF KRGAFHLAVQ AQVPIVPIVM SSYQDFYCKK ERRFTSGRCQ VRVLPPVPTE
250 260 270 280
GLKPDDVPAL ADRVRHSMLT VFREISTDGR GGGDYLKKPG GVGEAGL