Q95218

PR
Gene name
Dmbt1
Protein name
Deleted in malignant brain tumors 1 protein
Names
Hensin
Species
Oryctolagus cuniculus (Rabbit)
KEGG Pathway
ocu:100008679
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-72 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q95218

Entry ID Method Resolution Chain Position Source
AF-Q95218-F1 Predicted AlphaFoldDB

No variants for Q95218

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q95218

No associated diseases with Q95218

20 regional properties for Q95218

Type Name Position InterPro Accession
domain CUB domain 951 - 1061 IPR000859-1
domain CUB domain 1192 - 1301 IPR000859-2
domain SRCR domain 53 - 153 IPR001190-1
domain SRCR domain 192 - 292 IPR001190-2
domain SRCR domain 323 - 423 IPR001190-3
domain SRCR domain 454 - 551 IPR001190-4
domain SRCR domain 582 - 682 IPR001190-5
domain SRCR domain 713 - 813 IPR001190-6
domain SRCR domain 821 - 921 IPR001190-7
domain SRCR domain 1067 - 1170 IPR001190-8
domain Zona pellucida domain 1310 - 1558 IPR001507
domain SRCR-like domain 53 - 153 IPR017448-1
domain SRCR-like domain 192 - 292 IPR017448-2
domain SRCR-like domain 323 - 423 IPR017448-3
domain SRCR-like domain 454 - 551 IPR017448-4
domain SRCR-like domain 582 - 682 IPR017448-5
domain SRCR-like domain 713 - 813 IPR017448-6
domain SRCR-like domain 821 - 921 IPR017448-7
domain SRCR-like domain 1067 - 1170 IPR017448-8
conserved_site Zona pellucida domain, conserved site 1460 - 1500 IPR017977

Functions

Description
EC Number
Subcellular Localization
  • Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
extrinsic component of membrane The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
zymogen granule membrane The lipid bilayer surrounding a zymogen granule.

2 GO annotations of molecular function

Name Definition
scavenger receptor activity Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs).
zymogen binding Binding to a zymogen, an enzymatically inactive precursor of an enzyme that is often convertible to an active enzyme by proteolysis.

4 GO annotations of biological process

Name Definition
cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
defense response to Gram-negative bacterium Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
defense response to Gram-positive bacterium Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGISTVLALS LLWGPALSQG QWIPYTTYHD SVSSPGAPVE TTTTEVFPSG LELRLANGGD
70 80 90 100 110 120
RCQGRVEVLY QGSWGTVCDD GWDINDAQVV CRQLGCGMAV SAPGSARFGQ GPGQIVLDDV
130 140 150 160 170 180
SCSGQEPYLW SCHHRGWLSH NCGHQEDAGV ICSDAMAMTS PPPDTWPTTV IYESTPHFPS
190 200 210 220 230 240
GLELVFPSGL ELRLANGSDR CQGRVEVLYQ GSWGTVCDDG WDINDAQVVC RQLGCGMAVS
250 260 270 280 290 300
APGSARFGQG PGQIVLDDVS CSGQEPYLWS CHHRGWLSHN CGHQEDAGVI CSDAVPTTTP
310 320 330 340 350 360
PPDTWPTTVI YESSPVFPSG LELRLANGSD RCQGRVEVLY QGSWGTVCDD GWDINDAQVV
370 380 390 400 410 420
CRQLGCGTAV SAPGSARFGQ GPGQIVLDDV SCSGQEPYLW SCHHRGWLSH NCGHQEDAGV
430 440 450 460 470 480
ICSDAMAMTT PLPDTWPTTV IHESTPVFPS GLELQLANGS DRCQGRVEVL YQGTVCDDGW
490 500 510 520 530 540
DINDAQVVCR QLGCGMAVSA PGSARFGQGP GQIVLDDVSC SGQEPYLWSC HHRGWLSHNC
550 560 570 580 590 600
GHQEDAGVIC SDAMAMTTPP PDTWPTTVIY ESTPHFPSGL ELRLANGSDR CQGRVEVLYQ
610 620 630 640 650 660
GSWGTVCDDG WDINDAQVVC RQLGCGTAVS APGSARFGQG PGQIVLDDVS CSGQEPYLWS
670 680 690 700 710 720
CHHRGWLSHN CGHQEDAGVI CSGAMDTTTP LPDTWPTTVI YESTPVHISG LQLRLVNGSD
730 740 750 760 770 780
RCEGRVEVLY QGSWGTVCDD SWDLNDASVV CRQLGCGTAL SAPASAQFGQ SSGSIVLDDV
790 800 810 820 830 840
SCSGSEPNLW SCSHRGWLSH NCGHHEDAGV VCSGPDSRLA VRLVNGSTRC QGRVEVLYRG
850 860 870 880 890 900
SWGTVCDDSW DINDASVVCR QLGCGWAVSA PGSARFGQGS GSIFLDEVSC SGQEPYLWNC
910 920 930 940 950 960
SHRGWLSHNC GHYEDAGVIC SDGWTTVTPP APTTDWWEPT VTTTVGPSSN CGGFLYNATG
970 980 990 1000 1010 1020
SFSSPSYPGY YPNNALCVWE IAVPSGYLIN LGFSQLRLEQ HSYCNFDYVE IFDGSTDSSL
1030 1040 1050 1060 1070 1080
LGKICNDSGQ IFTTSSNRMT VLFRSDISVQ NTGFLAWYNS FPRDASLRLV SGNSSYGACA
1090 1100 1110 1120 1130 1140
GRVEIYHGGR WGTVCDDSWD TQDAQVVCRQ LQCGDAVSAP GGAYFGSGSG PITLDDVNCS
1150 1160 1170 1180 1190 1200
GTEATLWQCR SQSWFSHNCG HHEDASVICT GNYGTTTASV PNISTSNASY SCGGFLSQHS
1210 1220 1230 1240 1250 1260
GRFSSPFYPG NYPNNARCVW DIEVQNNYQV TVTFTDVQLE GGCQYDYIEV FDGPYHSSPL
1270 1280 1290 1300 1310 1320
IARVCDGARG SFTSSSNFLS VRFVSDGSIT RRGFQAEFYS LPSNDSTNLL CLMNHMQASV
1330 1340 1350 1360 1370 1380
SRAYLQSLGF SAWELVVSGW NGNYQCQRQI TPSQVIFTIP YSGCGTIKQV DNETITYSNF
1390 1400 1410 1420 1430 1440
LKAAVSSGVI KRKKDLHIHV SCRMLQDSWV HTMYIANDTI EVSEVQYSNF NVNVSFYTSS
1450 1460 1470 1480 1490 1500
SFSYPVTSSP YYVDLDQNLY LQAEILHSDA SLALFVDTCV ASPNPNDFTS VTYDLIRSGC
1510 1520 1530 1540 1550 1560
VRDETYRSYA QPSPRVVRFR FNSFHFLNRF PAVYLRCKMV VCRAYDYSSR CYRGCVVRSK
1570 1580 1590
RDVGSYQERV DVVLGPIQLL DPPAGKKSPG KGSP