Q95032

PR
Gene name
metK (sams)
Protein name
S-adenosylmethionine synthase
Names
AdoMet synthase, Methionine adenosyltransferase, MAT
Species
Acanthamoeba castellanii (Amoeba)
KEGG Pathway
EC number
2.5.1.6: Transferring alkyl or aryl groups, other than methyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-50 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q95032

Entry ID Method Resolution Chain Position Source
AF-Q95032-F1 Predicted AlphaFoldDB

No variants for Q95032

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q95032

No associated diseases with Q95032

5 regional properties for Q95032

Type Name Position InterPro Accession
domain S-adenosylmethionine synthetase, N-terminal 7 - 104 IPR022628
domain S-adenosylmethionine synthetase, central domain 119 - 239 IPR022629
domain S-adenosylmethionine synthetase, C-terminal 241 - 381 IPR022630
conserved_site S-adenosylmethionine synthetase, conserved site 120 - 130 IPR022631-1
conserved_site S-adenosylmethionine synthetase, conserved site 267 - 275 IPR022631-2

Functions

Description
EC Number 2.5.1.6 Transferring alkyl or aryl groups, other than methyl groups
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
methionine adenosyltransferase activity Catalysis of the reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine.

2 GO annotations of biological process

Name Definition
one-carbon metabolic process The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states.
S-adenosylmethionine biosynthetic process The chemical reactions and pathways resulting in the formation of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MASSKTLLFT SECVSESHPD KLCDQVSDAI LDACLANDPY SKVACETASK TGMVMVFGEI
70 80 90 100 110 120
TTKSSFDYQK VIRETVKRIG FTDSSIGFDY KTCNILVAIE QQSPDIAQGV HVGRSDDDLG
130 140 150 160 170 180
AGDQGHMFGH ATNETPEFMP MTHVLATRLC QRMTEVRNNS ILSWMRPDAK TQVTVEYRNE
190 200 210 220 230 240
NGTLIPLRRH TVVISVQHSE DVTNEEIRKR LMEEVIKPSI PAHLLDGETI FHLNPSGRFV
250 260 270 280 290 300
IGGPQGEAGL TGGKIIIDTY GGWGAHGGGA FSGKDPSKVD RSAAYAARWI AKSLVARGLA
310 320 330 340 350 360
NRALVQVSYA IGVSHPLSVF VDSYGTAQGG RTDEDLLAIS KSNFDLRPGK IINDLQLRRP
370 380
IYEKTAYHGH FGRNDPDFLW EAPKKLNF