Q94FL5
Gene name |
REV7 (At1g16590, F19K19.10) |
Protein name |
DNA polymerase zeta processivity subunit |
Names |
Revertibility protein 7 homolog, AtREV7, REV7 homolog |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G16590 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q94FL5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q94FL5-F1 | Predicted | AlphaFoldDB |
17 variants for Q94FL5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH00027112 | 2 | S>N | No | 1000Genomes | |
| ENSVATH01059715 | 3 | R>L | No | 1000Genomes | |
| ENSVATH01059716 | 6 | D>N | No | 1000Genomes | |
| ENSVATH00027116 | 18 | D>E | No | 1000Genomes | |
| tmp_1_5674079_C_T | 35 | P>S | No | 1000Genomes | |
| ENSVATH04586515 | 54 | H>Q | No | 1000Genomes | |
| ENSVATH04586516 | 62 | H>Y | No | 1000Genomes | |
| tmp_1_5674243_G_T | 65 | A>S | No | 1000Genomes | |
| ENSVATH11343865 | 69 | L>F | No | 1000Genomes | |
| ENSVATH04586518 | 75 | G>C | No | 1000Genomes | |
| ENSVATH04586519 | 91 | P>S | No | 1000Genomes | |
| ENSVATH01059725 | 99 | I>L | No | 1000Genomes | |
| ENSVATH01059726 | 112 | G>D | No | 1000Genomes | |
| ENSVATH01059727 | 130 | S>P | No | 1000Genomes | |
| ENSVATH11343866 | 164 | P>L | No | 1000Genomes | |
| ENSVATH00027122 | 199 | S>P | No | 1000Genomes | |
| ENSVATH00027123 | 208 | E>K | No | 1000Genomes |
No associated diseases with Q94FL5
1 regional properties for Q94FL5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | HORMA domain | 10 - 193 | IPR003511 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| zeta DNA polymerase complex | A heterodimeric DNA polymerase complex that catalyzes error-prone DNA synthesis in contexts such as translesion synthesis and double-stranded break repair. First characterized in Saccharomyces, in which the subunits are Rev3p and Rev7p; a third protein, Rev1p, is often associated with the polymerase dimer. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to DNA damage stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. |
| DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. |
| response to UV-B | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-B radiation stimulus. UV-B radiation (UV-B light) spans the wavelengths 280 to 315 nm. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSRKDDNQSG | EVGRTLVDFM | EVAITMIVYL | KGFYPSAAFE | RRRYMNVVVQ | RARHPELRDY |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IHSAASGLLP | FIEKGLVERV | AVVFFSEDNV | PVERFIFKIT | IKPSCAALVE | EGQLEFALRS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FLIKLSVSKS | LVKPLPLNCR | WEVTAYLRSL | PQVGSSKEAE | LWIPTDTKQW | QNPPVLTPVK |
| 190 | 200 | 210 | |||
| SLNSEPLCLQ | LYLEHPSLSE | PLNLVNPEDV | APHDP |