AiPD: Autoinhibited Protein Database

Gene name	AHASS1
Protein name	Acetolactate synthase small subunit 1, chloroplastic
Names	ALS-interacting protein 1, Acetohydroxyacid synthase small subunit 1
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT2G31810
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-107 (Predicted disordered autoinhibitory region) PR

1-107 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
6U9H	EM	380 A	F/G/J/K/N/O/R/S	1-491	PDB
6VZ8	EM	345 A	F/G/J/K/N/O/R/S	1-491	PDB
AF-Q93YZ7-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
ENSVATH00256135	33	S>A	No	1000Genomes
tmp_2_13524368_C_T	33	S>L	No	1000Genomes
ENSVATH00256136	39	S>A	No	1000Genomes
tmp_2_13524467_A_T	66	K>M	No	1000Genomes
ENSVATH13498955	70	A>V	No	1000Genomes
tmp_2_13524491_A_T	74	E>V	No	1000Genomes
tmp_2_13524598_T_C	84	V>A	No	1000Genomes
tmp_2_13524652_G_A	102	R>K	No	1000Genomes
ENSVATH01935556	153	L>I	No	1000Genomes
ENSVATH13498962	186	L>V	No	1000Genomes
tmp_2_13525191_C_A	188	D>E	No	1000Genomes
tmp_2_13526059_C_A	253	A>E	No	1000Genomes
ENSVATH05640425	265	S>N	No	1000Genomes
tmp_2_13526872_T_A	339	V>D	No	1000Genomes
ENSVATH13498977	340	F>L	No	1000Genomes
ENSVATH05640435	375	S>N	No	1000Genomes
ENSVATH00256147	385	V>I	No	1000Genomes
tmp_2_13527103_A_C	389	E>A	No	1000Genomes
ENSVATH00256149	399	S>A	No	1000Genomes
tmp_2_13527823_T_C	449	V>A	No	1000Genomes
ENSVATH05640449	474	E>D	No	1000Genomes

Type	Name	Position	InterPro Accession
domain	Phospholipid/glycerol acyltransferase	83 - 213	IPR002123
domain	1-acyl-sn-glycerol-3-phosphate acyltransferase	81 - 210	IPR004552

		Description
EC Number
Subcellular Localization	Plastid, chloroplast Peroxisome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
chloroplast	A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
peroxisome	A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.

Name	Definition
acetolactate synthase activity	Catalysis of the reaction: 2 pyruvate = 2-acetolactate + CO2.
acetolactate synthase regulator activity	Binds to and modulates the activity of acetolactate synthase.
protein self-association	Binding to a domain within the same polypeptide.

Name	Definition
isoleucine biosynthetic process	The chemical reactions and pathways resulting in the formation of isoleucine, (2R,3R)-2-amino-3-methylpentanoic acid.
regulation of catalytic activity	Any process that modulates the activity of an enzyme.
response to hypoxia	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
valine biosynthetic process	The chemical reactions and pathways resulting in the formation of valine, 2-amino-3-methylbutanoic acid.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins