Q93YA3
Gene name |
TDC1 (TASY) |
Protein name |
Taxadiene synthase |
Names |
Taxa-4(5),11(12)-diene synthase |
Species |
Taxus baccata (English yew) |
KEGG Pathway |
|
EC number |
4.2.3.17: Acting on phosphates |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q93YA3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q93YA3-F1 | Predicted | AlphaFoldDB |
No variants for Q93YA3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q93YA3 | |||||
No associated diseases with Q93YA3
13 regional properties for Q93YA3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | AAA+ ATPase domain | 1788 - 2114 | IPR003593-1 |
| domain | AAA+ ATPase domain | 2410 - 2560 | IPR003593-2 |
| domain | AAA+ ATPase domain | 2752 - 2918 | IPR003593-3 |
| domain | Dynein heavy chain region D6 P-loop domain | 3792 - 3894 | IPR004273 |
| domain | Dynein heavy chain, tail | 220 - 763 | IPR013594 |
| domain | Dynein heavy chain, linker | 1221 - 1626 | IPR013602 |
| domain | Dynein heavy chain, AAA module D4 | 2732 - 2935 | IPR024317 |
| domain | Dynein heavy chain, coiled coil stalk | 3018 - 3346 | IPR024743 |
| domain | Dynein heavy chain, hydrolytic ATP-binding dynein motor region | 1758 - 2081 | IPR035699 |
| domain | Dynein heavy chain, ATP-binding dynein motor region | 3378 - 3597 | IPR035706 |
| domain | Dynein heavy chain 3, AAA+ lid domain | 2608 - 2681 | IPR041589 |
| domain | Dynein heavy chain AAA lid domain | 3929 - 4016 | IPR041658 |
| domain | DYN1, AAA+ ATPase lid domain | 2223 - 2358 | IPR048404 |
Functions
| Description | ||
|---|---|---|
| EC Number | 4.2.3.17 | Acting on phosphates |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| magnesium ion binding | Binding to a magnesium (Mg) ion. |
| taxadiene synthase activity | Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = diphosphate + taxa-4,11-diene. |
| terpene synthase activity | Catalysis of the formation of cyclic terpenes through the cyclization of linear terpenes (e.g. isopentenyl-PP, geranyl-PP, farnesyl-PP and geranylgeranyl-PP) containing varying numbers of isoprene units. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| paclitaxel biosynthetic process | The chemical reactions and pathways resulting in the formation of paclitaxel, a tetracyclic diterpenoid isolated originally from the bark of the Pacific yew tree, Taxus brevifolia. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAQLSFNAAL | KMNALGNKAI | HDPTNCRAKS | ERQMMWVCSR | SGRTRVKMSR | GSGGPGPVVM |
| 70 | 80 | 90 | 100 | 110 | 120 |
| MSSSTGTSKV | VSETSSTIVD | DIPRLSANYH | GDLWHHNVIQ | TLETPFRESS | TYQERADELV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VKIKDMFNAL | GDGDISPSAY | DTAWVARVAT | VSSDGSEKPR | FPQALNWVLN | NQLQDGSWGI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ESHFSLCDRL | LNTVNSVIAL | SVWKTGHSQV | EQGAEFIAEN | LRLLNEEDEL | SPDFEIIFPA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LLQKAKALGI | NLPYDLPFIK | SLSTTREARL | TDVSAAADNI | PANMLNALEG | LEEVIDWNKI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| MRFQSKDGSF | LSSPASTACV | LMNTGDEKCF | TLLNNLLDKF | GGCVPCMYSI | DLLERLSLVD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NIEHLGIGRH | FKQEIKVALD | YVYRHWSERG | IGWGRDSLVP | DLNTTALGLR | TLRTHGYDVS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SDVLNNFKDE | NGRFFSSAGQ | THVELRSVVN | LFRASDLAFP | DEGAMDDARK | FAEPYLRDAL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ATKISTNTKL | YKEIEYVVEY | PWHMSIPRLE | ARSYIDSYDD | DYVWQRKTLY | RMPSLSNSKC |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LELAKLDFNI | VQSLHQEELK | LLTRWWKESG | MADINFTRHR | VAEVYFSSAT | FEPEYSATRI |
| 610 | 620 | 630 | 640 | 650 | 660 |
| AFTKIGCLQV | LFDDMADIFA | TLDELKSFTE | GVKRWDTSLL | HEIPECMQTC | FKVWFKLMEE |
| 670 | 680 | 690 | 700 | 710 | 720 |
| VNNDVVKVQG | RDMLAHIRKP | WELYFNCYVQ | EREWLEAGYI | PTFEEYLKTY | AISVGLGPCT |
| 730 | 740 | 750 | 760 | 770 | 780 |
| LQPILLMGEL | VKDDVVEKVH | YPSNMFELVS | LSWRLTNDTK | TYQAEKARGQ | QASGIACYMK |
| 790 | 800 | 810 | 820 | 830 | 840 |
| DNPGATEEDA | IKHICRVVDR | ALKEASFEYF | KPSNDIPMGC | KSFIFNLRLC | VQIFYKFIDG |
| 850 | 860 | ||||
| YGIANEEIKD | YIRKVYIDPI | QV |