Q93873

PR
Gene name
gas-1 (K09A9.5)
Protein name
Probable NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial
Names
Complex I-49kD, CI-49kD, NADH-ubiquinone oxidoreductase 49 kDa subunit
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_K09A9.5
EC number
7.1.1.2: Hydron translocation or charge separation linked to oxidoreductase reactions
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-125 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q93873

Entry ID Method Resolution Chain Position Source
AF-Q93873-F1 Predicted AlphaFoldDB

No variants for Q93873

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q93873

No associated diseases with Q93873

2 regional properties for Q93873

Type Name Position InterPro Accession
domain NADH-quinone oxidoreductase, subunit D 212 - 482 IPR001135
conserved_site NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site 135 - 146 IPR014029

Functions

Description
EC Number 7.1.1.2 Hydron translocation or charge separation linked to oxidoreductase reactions
Subcellular Localization
  • Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
mitochondrial respiratory chain complex I A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone.

5 GO annotations of molecular function

Name Definition
4 iron, 4 sulfur cluster binding Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
metal ion binding Binding to a metal ion.
NAD binding Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.
NADH dehydrogenase (ubiquinone) activity Catalysis of the reaction: NADH + ubiquinone + 5 H(+)(in) <=> NAD(+) + ubiquinol + 4 H(+)(out).
quinone binding Binding to a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds.

2 GO annotations of biological process

Name Definition
mitochondrial electron transport, NADH to ubiquinone The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation.
response to xenobiotic stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q95H42 ndhH NAD(P)H-quinone oxidoreductase subunit H, chloroplastic Triticum aestivum (Wheat) PR
P25709 ndhH NAD(P)H-quinone oxidoreductase subunit H, chloroplastic Zea mays (Maize) PR
A4GYX2 ndhH NAD(P)H-quinone oxidoreductase subunit H, chloroplastic Populus trichocarpa (Western balsam poplar) (Populus balsamifera subsp. trichocarpa) PR
Q2VEC5 ndhH NAD(P)H-quinone oxidoreductase subunit H, chloroplastic Solanum tuberosum (Potato) PR
A1E9Y0 ndhH NAD(P)H-quinone oxidoreductase subunit H, chloroplastic Sorghum bicolor (Sorghum) (Sorghum vulgare) PR
P56753 ndhH NAD(P)H-quinone oxidoreductase subunit H, chloroplastic Arabidopsis thaliana (Mouse-ear cress) PR
Q2MI44 ndhH NAD(P)H-quinone oxidoreductase subunit H, chloroplastic Solanum lycopersicum (Tomato) (Lycopersicon esculentum) PR
10 20 30 40 50 60
MLGRKIAGTC LRANVPSVAA TSSTPATQTR NSHTIWYPDA KFERQFKTGG TLGKLWMSER
70 80 90 100 110 120
VSDFDEKIGL DKLEKLAYSD PVMSDNYSGK QREKNLENMI LNFGPQHPAA HGVLRLVLKL
130 140 150 160 170 180
EGEVIIKAIP HIGLLHRATE KLIEHKTYTQ ALPYFDRLDY VSMMCNEQAW SLAVEKLLGI
190 200 210 220 230 240
DIPTRAKYIR TLMGELTRIQ NHIMGITTHA LDVGAMTPFF WMFEEREKLF EFSERVSGAR
250 260 270 280 290 300
MHANYVRPGG VAWDLPIGLM DDIYDWAIKF PERIDELEDM LTENRIWKAR TIDIGLVSAA
310 320 330 340 350 360
DALNWGFSGV MVRGSGIKQD VRKTEPYDAY ADMEFDVPIG TKGDCYDRYL CRIEEMRQSL
370 380 390 400 410 420
NIVHQCLNKM PAGEIKVDDH KVVPPKRAEM KENMESLIHH FKFFTEGFQV PPGATYVPIE
430 440 450 460 470 480
APKGEFGVYL VADGTGKPYR CFIRAPGFAH LAAIHDVCYM SLIADIVAVI GTMDIVFGEV
DR