Q92ZJ6

PR
Gene name
dnaE2-2
Protein name
Error-prone DNA polymerase 2
Names
Species
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
KEGG Pathway
sme:SMa0892
EC number
2.7.7.7: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1009-1079 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q92ZJ6

Entry ID Method Resolution Chain Position Source
AF-Q92ZJ6-F1 Predicted AlphaFoldDB

No variants for Q92ZJ6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q92ZJ6

No associated diseases with Q92ZJ6

6 regional properties for Q92ZJ6

Type Name Position InterPro Accession
domain Polymerase/histidinol phosphatase, N-terminal 3 - 70 IPR003141
domain PHP domain 4 - 121 IPR004013
domain OB-fold nucleic acid binding domain, AA-tRNA synthetase-type 918 - 983 IPR004365
domain Bacterial DNA polymerase III, alpha subunit, NTPase domain 263 - 501 IPR011708
domain DNA polymerase, helix-hairpin-helix motif 741 - 828 IPR029460
domain DNA polymerase III alpha subunit finger domain 504 - 667 IPR040982

Functions

Description
EC Number 2.7.7.7 Nucleotidyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
3'-5' exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.
DNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.

3 GO annotations of biological process

Name Definition
DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
DNA replication The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
SOS response An error-prone process for repairing damaged microbial DNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRYAELQVTT HFSFLRAASS AEELFATARL MGIEALGVVD RNSLAGIVRA LEASRATGLR
70 80 90 100 110 120
LVVGCRLDLQ DGMSILVYPT DRAAYSRLTR LLTLGKGRGG KANCIIHFDD VALYAEGLIG
130 140 150 160 170 180
ILVPDLADEV CAVQLRKIAE VFGDRAYVSL CLRRRPNDQL QLHELTNLAV KHRVKTIVTN
190 200 210 220 230 240
DVLFHEHGRR QLQDVVTCIR TGMTIDDVGF ERERHADRYL KPPEEMARLF PAYPEALART
250 260 270 280 290 300
MEIVERCRFS LEELVYQYPE EALILGMTAQ QSLQHYTWEG VRARYPEGLP THVEKTIRHE
310 320 330 340 350 360
LALIETMKYA PYFLTVFSIV RYARSQGILC QGRGSAANSA VCYVLGITSI DPETNDLLFE
370 380 390 400 410 420
RFVSQERDEP PDIDVDFEHE RREEVIQWIY KTYGHDKAAL CSTVTRYRAK GAIRDVGKAL
430 440 450 460 470 480
DLPEDLIRTL SSGIWSWSET VGERQVRELG LNPDDRRLTL TLRLAQQLMG APRNLSQHPG
490 500 510 520 530 540
GFVLTHDRLD DLVPIEPATM ADRQVIEWDK DDIEALKFLK VDVLALGMLT CMAKAFALIS
550 560 570 580 590 600
EHKHEDIDLA TIPQEDPATY AMIRKADTLG TFQIESRAQM SMLPRMKPRT FYDLVIQVAI
610 620 630 640 650 660
VRPGPIQGDM VHPYLRRREG KEKVEYPTPE LEAVLHKTLG VPLFQESAMR VAMVCAGFTG
670 680 690 700 710 720
GEADQLRKSM ATFKFTGGVS RFKDKLVNGM IRNGYTKEFA EKTFSQLEGF GSYGFPESHA
730 740 750 760 770 780
ASFALIAYAS NYIKCYFPDV FCAALLNSQP MGFYAPAQIV RDAREHGVEV RPICINRSRW
790 800 810 820 830 840
DCMLEPIDGS GGHAVRLGMR LVRGLATADA ARIVAARADE PFTSVDDMWR RSGVPVASLV
850 860 870 880 890 900
ELAEADAFLP SLSLERRDAL WAIKALRDEP LPLFTAAADR EARAIAEQEE PEVELRQMTD
910 920 930 940 950 960
GQNVVEDYSH TGLTLREHPL RFMRDDLAKR RIVTCAQAMT AHDGQWLMAA GLVLVRQRPG
970 980 990 1000 1010 1020
SAKGVMFITI EDETGIANIV VWPKLFERSR RVVLGASMMA INGRIQREGE VVHLVAQQLF
1030 1040 1050 1060 1070 1080
DLSADLSSLA ERDGAFRPPT GRGDEFAHGS PGSADSRGKA PPGVRARDIL VPDLHIDTLK
IKSRNFQ