Q92NF5

PR
Gene name
lcdH (R02250, SMc01638)
Protein name
L-carnitine dehydrogenase
Names
CDH, L-CDH
Species
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
KEGG Pathway
sme:SMc01638
EC number
1.1.1.108: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

21-154 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q92NF5

Entry ID Method Resolution Chain Position Source
AF-Q92NF5-F1 Predicted AlphaFoldDB

No variants for Q92NF5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q92NF5

No associated diseases with Q92NF5

2 regional properties for Q92NF5

Type Name Position InterPro Accession
domain 3-hydroxyacyl-CoA dehydrogenase, C-terminal 186 - 251 IPR006108
domain 3-hydroxyacyl-CoA dehydrogenase, NAD binding 6 - 182 IPR006176

Functions

Description
EC Number 1.1.1.108 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
carnitine 3-dehydrogenase activity Catalysis of the reaction: carnitine + NAD(+) = 3-dehydrocarnitine + H(+) + NADH.
NAD+ binding Binding to the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions.

2 GO annotations of biological process

Name Definition
carnitine catabolic process The chemical reactions and pathways resulting in the breakdown of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane.
fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTTITKAACI GGGVIGGAWA ARFALAGIDV NIFDPHPEAE RIIGEVMANA ERAYGMLTMA
70 80 90 100 110 120
PLPPRGKFTF CRSIQEAVEG VDWIQESVPE RLPLKRGVIN EIDAAARPDA LIGSSTSGLL
130 140 150 160 170 180
PSDLQAEMKH PERMFVAHPY NPVYLLPLVE LVGGRKTSPE TIRRAEEAVA EIGMKGVVIA
190 200 210 220 230 240
KEIEAFVGDR LLEALWREAL WLIQDDICDT ETLDDVMRYS FGMRWAQMGL FETYRIAGGE
250 260 270 280 290 300
AGMRHFLAQF GPCLKWPWTK FTDVVDLDDA LVEKIGAQSD AQAAGRSIRE LERIRDENLV
310 320 330 340 350 360
GIMHALKAGD GGKGWGAGKL LADFEKRLWE KGGSPSKSLD ASGPLRLVDT KVNAAWVDYN
370 380 390 400 410 420
GHMTEHRYLQ LFGDTSDALL KVIGVDFAYV EAGHSYYTVE THIRHLGEAK LGQALYTTLQ
430 440 450 460 470 480
LLSSDEKRIH FFTRIHDAAS GDVIATAEQM MLHVDAKAGK SVPAPAEVMA KLKPIAEGHA
490
KLDAPDGAGR HVGQKR