Q92H87

PR
Gene name
gyrB
Protein name
DNA gyrase subunit B
Names
Species
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
KEGG Pathway
rco:RC0884
EC number
5.6.2.2: Enzymes altering nucleic acid conformation
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-47 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q92H87

Entry ID Method Resolution Chain Position Source
AF-Q92H87-F1 Predicted AlphaFoldDB

No variants for Q92H87

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q92H87

No associated diseases with Q92H87

6 regional properties for Q92H87

Type Name Position InterPro Accession
domain Elongation factor EFG, domain V-like 470 - 549 IPR000640
domain Translational (tr)-type GTP-binding domain 68 - 248 IPR000795
domain Small GTP-binding protein domain 72 - 234 IPR005225
domain GTP-binding protein LepA, C-terminal 559 - 664 IPR013842
conserved_site Tr-type G domain, conserved site 107 - 122 IPR031157
domain Elongation factor 4, domain IV 472 - 551 IPR035654

Functions

Description
EC Number 5.6.2.2 Enzymes altering nucleic acid conformation
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined, driven by ATP hydrolysis. The enzyme changes the linking number in multiples of 2.
metal ion binding Binding to a metal ion.

2 GO annotations of biological process

Name Definition
DNA topological change The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
DNA-templated DNA replication A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSEIEEKFNE SSYGADSIKV LKGLEAVRKR PGMYIGDVGD GSGLHHMIYE VVDNAIDESL
70 80 90 100 110 120
AGYCDLVRVT LNKNGSVTVS DNGRGIPVEI HGEEGISAAE VIMTQLHAGG KFDQNAYKVA
130 140 150 160 170 180
GGLHGVGVSV VNALSEWLEL RIWRNNKEYL MRFNNGITEA PLAVVKENID KKGTEVTFFP
190 200 210 220 230 240
SVETFTNIEF DFGTIEHRLR ELAFLNSGVK ILLVDNRFEE VKEVEFYYTG GIEAYVKYID
250 260 270 280 290 300
RAKHAIHPCI VVNTENAESG ISLELAMHWN DSYHENILCF TNNIRQRDGG THLSAFKSAI
310 320 330 340 350 360
TRVITSYLDT TGLNKKAKNY FSGEDTREGL CCVLSVKVPD PKFSSQTKDK LVSSEVRPVV
370 380 390 400 410 420
ENAVYTKVLE WFEEHPAEAK AIIAKIMEAA NAREAARKAR ELTRRKSALE VSNLPGKLAD
430 440 450 460 470 480
CHAKDPAISE LFIVEGDSAG GTAKQGRDSK IQAILPLRGK ILNVERARFD KMLGSDQIGT
490 500 510 520 530 540
LITALGISVE REFSLEKLRY HKVIIMTDAD VDGSHIRTLL LTFFYRHMPE LINKGYLYIA
550 560 570 580 590 600
QPPLYKVKKG AAEFYLKNEQ ALQDYLIKST INDATLILDD KERLVGDNLE ELINKVVKFN
610 620 630 640 650 660
GLLDHASKKF NRSITEILAI NDLLNNKIFE PESDLRLKKA LDVLNSLEDS PDKTNWEVLK
670 680 690 700 710 720
HENKIEFFRF SRGLKESKIL LKEQLESFEF VQISKFALTI FDIFSKQLKL IVKSQEFDIL
730 740 750 760 770 780
TPSQLLNTII ECGKRGINIQ RFKGLGEMNS DQLWETTLDP TKRTLLQVRV AEIDEAEGIF
790 800
STLMGDVVEP RRLFIQANAL NVVNLDV