Q92BG2

PR
Gene name
valS
Protein name
Valine--tRNA ligase
Names
Valyl-tRNA synthetase, ValRS
Species
Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262)
KEGG Pathway
lin:valS
EC number
6.1.1.9: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

815-882 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q92BG2

Entry ID Method Resolution Chain Position Source
AF-Q92BG2-F1 Predicted AlphaFoldDB

No variants for Q92BG2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q92BG2

No associated diseases with Q92BG2

5 regional properties for Q92BG2

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 50 - 61 IPR001412
domain Aminoacyl-tRNA synthetase, class Ia 23 - 566 IPR002300
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 609 - 752 IPR013155
domain Valyl-tRNA synthetase, tRNA-binding arm 815 - 880 IPR019499
domain Valyl tRNA synthetase, anticodon-binding domain 565 - 700 IPR033705

Functions

Description
EC Number 6.1.1.9 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
valine-tRNA ligase activity Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H(+).

1 GO annotations of biological process

Name Definition
valyl-tRNA aminoacylation The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. The valyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a valine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTEQNEINMP TKYEPSNVEA GKYKWWLEKE FFKAEGNSDK KPYSIVIPPP NVTGKLHLGH
70 80 90 100 110 120
AWDTTLQDII TRMKRMQGFD TLYLPGMDHA GIATQAKVEA KLKEENISRY DLGREKFVDK
130 140 150 160 170 180
TWEWKEEYAD FIREQWEKLG LGLDYSRERF TLDAGLSDAV KKVFVTLYNK GLIYRGQYII
190 200 210 220 230 240
NWDPEAKTAL SDIEVIHKDI EGSFYHLKYP LTDGSGYLEV ATTRPETIPG DTAVAVHPKD
250 260 270 280 290 300
ERYQHLIGKT IMLPILNREI PIVADEYVER EFGSGAVKIT PAHDPNDFEV GNRHDLPRII
310 320 330 340 350 360
VMHEDGTMND NAGKYDGLDR FVARKAIIQD FKDLGLFIKQ EPHLHSVGHS ERTGAVVEPY
370 380 390 400 410 420
LSLQWFVKME PLAAEALALQ KTEDKVNFVP ARFEKTYETW MDNIHDWCIS RQLWWGHRIP
430 440 450 460 470 480
AWYHKETGEI YVGENEPENL DQWEQDEDVL DTWFSSALWP FSTMGWPDTE NPDYKHFFPT
490 500 510 520 530 540
NTLVTGYDII FFWVSRMIFQ SVEFTGERPF KDTLIHGLVR DSEGRKMSKS LGNGVDPIEV
550 560 570 580 590 600
IDKYGADSLR YTLATGSSPG QDLKFSFEKV ESTWNFINKI WNASRFVLMN LDGMKYDEID
610 620 630 640 650 660
LSNVTEVSDK WILTRLNETI QAVTSLGEKY EFGEVGRTLY NFIWDDFCDW YIEIAKIPLY
670 680 690 700 710 720
GEDEVAKQTT RSVLAYTLNT TMRLLHPFMP FVTEEIWQNL PHEGESITIS NWPEVNEQQM
730 740 750 760 770 780
DSKASTAMRT LVEVIRAVRN IRAEVNTPLS KSIVLEIKPK DETYKEILEQ NISYIERFCN
790 800 810 820 830 840
PEKVTIAFDI EPSKTAMTAV VSGAEIFIPL EALIDLDLEI ARLEKELEKW NKEVARVQGK
850 860 870 880
LNNERFISKA PENVVAEERL KEKDYLEKKA SVLERIETLK EV