AiPD: Autoinhibited Protein Database

Q92747

Gene name	ARPC1A (SOP2L)
Protein name	Actin-related protein 2/3 complex subunit 1A
Names	SOP2-like protein
Species	Homo sapiens (Human)
KEGG Pathway	hsa:10552
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

260-335 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

260-335 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

2 structures for Q92747

Entry ID	Method	Resolution	Chain	Position	Source
6YW7	EM	450 A	C	1-370	PDB
AF-Q92747-F1	Predicted				AlphaFoldDB

196 variants for Q92747

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA368417274 rs1462466144	2	S>P		No	ClinGen gnomAD
CA368417286 rs1170404248	3	L>Q		No	ClinGen gnomAD
rs1427868082 CA368417284	3	L>V		No	ClinGen gnomAD
rs1363229886 CA368417294	4	H>Y		No	ClinGen gnomAD
rs1303163511 CA368417354	9	E>G		No	ClinGen gnomAD
CA4363538 rs766393624	11	I>M		No	ClinGen ExAC gnomAD
CA4363537 rs762792286	11	I>V		No	ClinGen ExAC gnomAD
rs149266584 CA4363539	17	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA368417449 rs1391822757	18	R>G		No	ClinGen gnomAD
rs1229874788 CA368417471	20	R>C		No	ClinGen gnomAD
CA368417474 rs759448154	20	R>H		No	ClinGen ExAC TOPMed gnomAD
CA4363540 rs759448154	20	R>L		No	ClinGen ExAC TOPMed gnomAD
CA4363541 rs144806851	21	T>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA163762106 rs201712782	21	T>I		No	ClinGen 1000Genomes
CA4363556 rs540837088	23	I>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1303918172 CA368417506	23	I>T		No	ClinGen gnomAD
CA368417511 rs1313025212	24	A>V		No	ClinGen gnomAD
rs760240726 CA163762656	28	N>S		No	ClinGen TOPMed
rs759358554 CA4363558	31	E>K		No	ClinGen ExAC gnomAD
rs1330112758 CA368417583	34	I>M		No	ClinGen gnomAD
rs1230440501 CA368417588	35	Y>C		No	ClinGen gnomAD
rs1460702509 CA368417598	36	K>N		No	ClinGen gnomAD
rs948572767 CA163762658	37	K>R		No	ClinGen TOPMed gnomAD
CA4363560 rs562099938	39	G>R		No	ClinGen 1000Genomes ExAC gnomAD
CA4363561 rs761938418	40	S>N		No	ClinGen ExAC gnomAD
rs1176146383 CA368417640	42	W>L		No	ClinGen gnomAD
rs1198716831 CA368417648	43	V>A		No	ClinGen TOPMed
rs765553717 CA4363562	45	A>T		No	ClinGen ExAC TOPMed gnomAD
CA163762659 rs142906076	46	H>R		No	ClinGen ESP
rs1473391237 CA368417679	48	L>V		No	ClinGen gnomAD
CA163762660 rs926009586	49	K>R		No	ClinGen Ensembl
CA368417703 rs1173808204	51	H>R		No	ClinGen gnomAD
rs1286844642 CA368417711	52	N>S		No	ClinGen TOPMed
CA4363564 rs763123089	53	G>R		No	ClinGen ExAC gnomAD
rs1425548319 CA368417726	54	H>Q		No	ClinGen TOPMed gnomAD
CA4363565 rs199988949	54	H>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs932128800 CA163762661	56	T>A		No	ClinGen TOPMed
CA4363589 rs547379680 COSM1453249	58	I>V	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC gnomAD
CA368418167 rs1175568269	60	W>*		No	ClinGen TOPMed
CA4363590 rs756536931	62	P>S		No	ClinGen ExAC gnomAD
rs756763453 CA4363593	65	D>G		No	ClinGen ExAC gnomAD
rs1264985190 CA368418212	65	D>N		No	ClinGen TOPMed
CA4363594 rs778562420	66	R>C		No	ClinGen ExAC TOPMed gnomAD
rs1368025200 CA368418226 COSM1453250	66	R>H	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA368418329 rs1406100266	77	Y>C		No	ClinGen gnomAD
rs140164246 CA4363595	80	S>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs758388290 CA4363596	81	Q>*		No	ClinGen ExAC
CA163763358 rs948990159	82	K>N		No	ClinGen TOPMed
CA4363597 rs780080032	84	G>S		No	ClinGen ExAC gnomAD
rs369324399 CA163763360	97	R>C		No	ClinGen ESP
CA368418539 rs1247110812	97	R>H		No	ClinGen gnomAD
CA163763361 COSM274054 rs1032525792	98	A>T	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs773238714 CA4363600	100	T>A		No	ClinGen ExAC gnomAD
CA163763362 rs904544696	101	F>L		No	ClinGen TOPMed gnomAD
CA163763363 rs892175396	102	V>L		No	ClinGen Ensembl
rs749505817 CA4363601	103	K>T		No	ClinGen ExAC TOPMed gnomAD
rs774390263 COSM1197581 CA163763364	106	P>A	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1256074182 CA368418607	106	P>L		No	ClinGen gnomAD
rs774390263 CA4363603	106	P>S		No	ClinGen ExAC TOPMed gnomAD
rs1425588491 CA368418642	111	F>C		No	ClinGen TOPMed
CA163763365 rs996740506	112	A>S		No	ClinGen Ensembl
rs1028182511 CA163763366	116	G>E		No	ClinGen Ensembl
rs370232879 CA4363608	118	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs983944152 CA163763368	122	V>L		No	ClinGen Ensembl
CA163763832 rs746134443	140	P>L		No	ClinGen gnomAD
rs777116048 CA4363628 COSM272125	142	R>H	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA4363630 rs139328388	145	V>I		No	ClinGen ESP ExAC gnomAD
rs750113267 CA4363631	147	S>G		No	ClinGen ExAC TOPMed gnomAD
rs1215354018 CA368418943	153	N>D		No	ClinGen TOPMed
rs1341990677 CA368418954	154	N>S		No	ClinGen TOPMed gnomAD
CA4363634 rs751088038	155	V>I		No	ClinGen ExAC TOPMed gnomAD
CA368418958 rs751088038	155	V>L		No	ClinGen ExAC TOPMed gnomAD
rs781029729 CA4363636	164	F>L		No	ClinGen ExAC gnomAD
CA368294923 rs1562801455	168	V>L		No	ClinGen Ensembl
rs1164787781 CA368294991	172	Y>C		No	ClinGen gnomAD
rs571833149 CA4363649	173	I>F		No	ClinGen ExAC gnomAD
rs571833149 CA163097546	173	I>V		No	ClinGen ExAC gnomAD
CA368295004 rs1451118438	174	K>E		No	ClinGen gnomAD
rs1451118438 CA368295003	174	K>Q		No	ClinGen gnomAD
rs756403062 CA163097551	174	K>T		No	ClinGen Ensembl
rs765993633 CA4363650	180	P>S		No	ClinGen ExAC TOPMed gnomAD
rs952422659 CA368295084	181	A>P		No	ClinGen TOPMed gnomAD
rs952422659 CA163097554	181	A>T		No	ClinGen TOPMed gnomAD
rs1436553465 COSM271989 CA368295126	183	T>M	large_intestine endometrium [Cosmic]	No	ClinGen cosmic curated gnomAD
CA368295233 rs1377531226	189	M>T		No	ClinGen gnomAD
CA163097563 rs573083020	190	P>A		No	ClinGen 1000Genomes ExAC gnomAD
CA4363653 rs573083020	190	P>T		No	ClinGen 1000Genomes ExAC gnomAD
CA4363655 rs150009166	194	L>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA368295434 rs1226764031	198	F>L		No	ClinGen gnomAD
rs376725540 CA4363656	199	G>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA368295467 rs1456217590	200	G>C		No	ClinGen TOPMed
CA4363657 rs145223474	200	G>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs11550144 CA163097573	207	V>F		No	ClinGen Ensembl
CA368295748 rs1584384312	207	V>G		No	ClinGen Ensembl
CA368295758 rs1378579075	208	H>P		No	ClinGen TOPMed
rs781736363 CA4363662	209	G>A		No	ClinGen ExAC gnomAD
CA4363661 rs768642928	209	G>R		No	ClinGen ExAC gnomAD
rs1584384330 CA368295821	210	V>G		No	ClinGen Ensembl
CA4363663 rs748658169	210	V>I		No	ClinGen ExAC gnomAD
rs1412172519 CA368295827	211	S>G		No	ClinGen gnomAD
CA4363665 rs773688364	215	S>G		No	ClinGen ExAC TOPMed gnomAD
rs773895160 CA4363668	217	S>N		No	ClinGen ExAC gnomAD
CA368296017 rs1209496423	218	R>C		No	ClinGen TOPMed
CA368296024 rs1303538597	218	R>H		No	ClinGen TOPMed gnomAD
rs1408294470 CA368296069	220	A>G		No	ClinGen gnomAD
rs1584384360 CA368296113	222	V>G		No	ClinGen Ensembl
rs1266272841 CA368296142	224	H>Y		No	ClinGen TOPMed
rs767022179 COSM1093777 CA4363670	225	D>N	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA4363672 rs760596520	228	V>M		No	ClinGen ExAC TOPMed gnomAD
rs147646339 CA163097599	230	V>A		No	ClinGen ESP gnomAD
rs764069129 CA4363674	232	D>A		No	ClinGen ExAC gnomAD
rs200602020 CA163097605	232	D>E		No	ClinGen Ensembl
rs764069129 CA4363673	232	D>V		No	ClinGen ExAC gnomAD
CA368296334 rs1297846118	233	A>G		No	ClinGen TOPMed
rs150004356 CA4363676	238	Q>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1168095915 CA368297913	239	V>F		No	ClinGen TOPMed gnomAD
rs1168095915 CA368297911	239	V>I		No	ClinGen TOPMed gnomAD
CA4363689 rs774962272	240	S>L		No	ClinGen ExAC TOPMed gnomAD
rs959257298 CA163098753	244	T>A		No	ClinGen TOPMed
rs375022680 CA368298041	245	E>D		No	ClinGen ESP
CA4363690 rs760218517	246	F>S		No	ClinGen ExAC gnomAD
rs761612783 CA4363693	250	L>R		No	ClinGen ExAC gnomAD
CA4363694 rs764935367	253	S>*		No	ClinGen ExAC gnomAD
CA163098776 rs200974680	255	V>A		No	ClinGen 1000Genomes
CA4363695 rs750287772	255	V>F		No	ClinGen ExAC gnomAD
rs199658497 CA4363697	258	N>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA368298260 rs1187679094	259	S>C		No	ClinGen gnomAD
rs368913591 CA4363699	259	S>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA4363700 rs201570380	260	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4363701 rs201570380	260	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs779134177 CA368298280	261	V>L		No	ClinGen ExAC TOPMed gnomAD
rs779134177 CA4363703	261	V>M		No	ClinGen ExAC TOPMed gnomAD
rs1584386397 CA368298311	263	A>G		No	ClinGen Ensembl
CA368299370 rs1353514891	266	D>E		No	ClinGen gnomAD
rs901011710 CA163099189	268	C>F		No	ClinGen TOPMed
rs922447965 CA163099186	268	C>R		No	ClinGen Ensembl
rs142247800 CA4363736	270	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1278076111 CA368299581	274	Y>C		No	ClinGen gnomAD
rs781337932 CA163099196	275	D>G		No	ClinGen Ensembl
CA368299602 rs1428599750	275	D>N		No	ClinGen gnomAD
CA368299643 rs1584387196	276	D>A		No	ClinGen Ensembl
CA4363738 rs187071817	277	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4363739 rs187071817	277	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs200959894 CA4363740	277	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs576410572 CA4363742	278	G>S		No	ClinGen 1000Genomes ExAC gnomAD
CA368299738 rs1365295123	279	C>F		No	ClinGen TOPMed gnomAD
rs1365295123 CA368299739	279	C>S		No	ClinGen TOPMed gnomAD
CA368299773 rs1584387224	281	T>P		No	ClinGen Ensembl
rs2286160 CA4363746	283	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs747559622 CA368299922	286	L>I		No	ClinGen ExAC TOPMed gnomAD
CA163099215 rs910006701	287	D>E		No	ClinGen TOPMed gnomAD
CA368299954 rs1305603218	287	D>G		No	ClinGen TOPMed gnomAD
CA4363748 rs755659135	288	I>L		No	ClinGen ExAC gnomAD
rs755659135 CA368299972	288	I>V		No	ClinGen ExAC gnomAD
CA4363749 rs777784312	291	Q>R		No	ClinGen ExAC gnomAD
CA4363751 rs529951024	295	R>C		No	ClinGen 1000Genomes ExAC gnomAD
CA368300575 rs1349181083	302	R>C		No	ClinGen gnomAD
CA368300579 rs1363073216	302	R>H		No	ClinGen TOPMed
CA368300722 rs1156685683	304	R>H		No	ClinGen TOPMed
rs776934695 CA4363755	305	N>S		No	ClinGen ExAC TOPMed gnomAD
rs137914882 CA4363756	308	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA368301041 rs1198178592	311	T>A		No	ClinGen TOPMed
CA4363758 rs773348651	315	R>H		No	ClinGen ExAC TOPMed gnomAD
CA4363760 rs766909995	316	N>D		No	ClinGen ExAC gnomAD
CA4363761 rs751880782	316	N>K		No	ClinGen ExAC gnomAD
rs1378168814 CA368301277	316	N>S		No	ClinGen gnomAD
CA4363762 rs755391152	317	T>A		No	ClinGen ExAC gnomAD
CA4363763 rs767015647	317	T>M		No	ClinGen ExAC TOPMed gnomAD
rs1237336619 CA368301416	319	L>S		No	ClinGen TOPMed
rs1223105723 CA368301578	324	Q>K		No	ClinGen TOPMed
CA368301654 rs1297798577	326	S>G		No	ClinGen TOPMed
rs1382792215 CA368301671	326	S>N		No	ClinGen TOPMed
rs759749177 CA4363780	335	V>M		No	ClinGen ExAC gnomAD
rs1365023857 CA368302857	336	D>H		No	ClinGen TOPMed gnomAD
CA4363781 rs767917071	337	K>E		No	ClinGen ExAC gnomAD
rs1297758151 CA368304120	337	K>N		No	ClinGen gnomAD
rs1320197623 CA368304126	338	Q>K		No	ClinGen gnomAD
rs753059514 CA4363782	339	D>A		No	ClinGen ExAC gnomAD
rs755771767 CA4363783	341	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
COSM1093779 CA368304188 rs1336685684	341	R>H	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs1206513602 CA368304261	345	T>A		No	ClinGen gnomAD
rs763882333 CA4363784	348	I>V		No	ClinGen ExAC gnomAD
rs1159010389 CA368304338	349	D>N		No	ClinGen TOPMed
CA163100223 rs987326157	352	M>L		No	ClinGen TOPMed gnomAD
rs987326157 CA368304398	352	M>V		No	ClinGen TOPMed gnomAD
CA4363785 rs187296347	354	I>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	357	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1584390308 CA368304902	359	T>P		No	ClinGen Ensembl
CA163100888 rs984482950	361	E>K		No	ClinGen TOPMed
CA4363814 rs374155785	363	S>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA4363815 rs758323414	367	L>I		No	ClinGen ExAC gnomAD
CA4363817 rs755155389	368	R>Q		No	ClinGen ExAC gnomAD
rs188648717 CA4363816	368	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs754781207 CA4363818	370	M>I		No	ClinGen ExAC TOPMed gnomAD
CA4363819 rs777900143	371	M>C		No	ClinGen ExAC gnomAD
CA368305225 rs1276241239	371	M>R		No	ClinGen gnomAD

No associated diseases with Q92747

No regional properties for Q92747

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q92747

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm, cytoskeleton Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

6 GO annotations of cellular component

Name	Definition
actin cytoskeleton	The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
Arp2/3 protein complex	A stable protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5), and functions in the nucleation of branched actin filaments.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
site of double-strand break	A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.

2 GO annotations of molecular function

Name	Definition
actin binding	Binding to monomeric or multimeric forms of actin, including actin filaments.
actin filament binding	Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.

3 GO annotations of biological process

Name	Definition
actin cytoskeleton organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
Arp2/3 complex-mediated actin nucleation	The actin nucleation process in which actin monomers combine to form a new branch on the side of an existing actin filament; mediated by the Arp2/3 protein complex and its interaction with other proteins.
regulation of actin filament polymerization	Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament.

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MSLHQFLLEP	ITCHAWNRDR	TQIALSPNNH	EVHIYKKNGS	QWVKAHELKE	HNGHITGIDW
70	80	90	100	110	120
APKSDRIVTC	GADRNAYVWS	QKDGVWKPTL	VILRINRAAT	FVKWSPLENK	FAVGSGARLI
130	140	150	160	170	180
SVCYFESEND	WWVSKHIKKP	IRSTVLSLDW	HPNNVLLAAG	SCDFKCRVFS	AYIKEVDEKP
190	200	210	220	230	240
ASTPWGSKMP	FGQLMSEFGG	SGTGGWVHGV	SFSASGSRLA	WVSHDSTVSV	ADASKSVQVS
250	260	270	280	290	300
TLKTEFLPLL	SVSFVSENSV	VAAGHDCCPM	LFNYDDRGCL	TFVSKLDIPK	QSIQRNMSAM
310	320	330	340	350	360
ERFRNMDKRA	TTEDRNTALE	TLHQNSITQV	SIYEVDKQDC	RKFCTTGIDG	AMTIWDFKTL

ESSIQGLRIM