AiPD: Autoinhibited Protein Database

Q92665

Gene name	MRPS31 (IMOGN38)
Protein name	28S ribosomal protein S31, mitochondrial
Names	MRP-S31, S31mt, Imogen 38, Mitochondrial small ribosomal subunit protein mS31
Species	Homo sapiens (Human)
KEGG Pathway	hsa:10240
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-274 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-274 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

43 structures for Q92665

Entry ID	Method	Resolution	Chain	Position	Source
3J9M	EM	350 A	AY	1-395	PDB
6NU2	EM	390 A	AY	276-383	PDB
6NU3	EM	440 A	AY	1-395	PDB
6RW4	EM	297 A	Y	1-395	PDB
6RW5	EM	314 A	Y	1-395	PDB
6VLZ	EM	297 A	AY	1-395	PDB
6VMI	EM	296 A	AY	1-395	PDB
6ZM5	EM	289 A	AY	1-395	PDB
6ZM6	EM	259 A	AY	1-395	PDB
6ZS9	EM	400 A	AY	1-395	PDB
6ZSA	EM	400 A	AY	1-395	PDB
6ZSB	EM	450 A	AY	1-395	PDB
6ZSC	EM	350 A	AY	1-395	PDB
6ZSD	EM	370 A	AY	1-395	PDB
6ZSE	EM	500 A	AY	1-395	PDB
6ZSG	EM	400 A	AY	1-395	PDB
7A5F	EM	440 A	Y6	1-395	PDB
7A5G	EM	433 A	Y6	1-395	PDB
7A5I	EM	370 A	Y6	1-395	PDB
7A5K	EM	370 A	Y6	1-395	PDB
7L08	EM	349 A	AY	1-395	PDB
7OG4	EM	380 A	AY	1-395	PDB
7P2E	EM	240 A	Y	1-395	PDB
7PNX	EM	276 A	Y	1-395	PDB
7PNY	EM	306 A	Y	1-395	PDB
7PNZ	EM	309 A	Y	1-395	PDB
7PO0	EM	290 A	Y	1-395	PDB
7PO1	EM	292 A	Y	1-395	PDB
7PO2	EM	309 A	Y	1-395	PDB
7PO3	EM	292 A	Y	1-395	PDB
7QI4	EM	221 A	AY	1-395	PDB
7QI5	EM	263 A	AY	1-395	PDB
7QI6	EM	298 A	AY	1-395	PDB
8ANY	EM	285 A	AY	1-395	PDB
8CSP	EM	266 A	Y	1-395	PDB
8CSQ	EM	254 A	Y	1-395	PDB
8CSR	EM	254 A	Y	1-395	PDB
8CSS	EM	236 A	Y	1-395	PDB
8CST	EM	285 A	Y	1-395	PDB
8CSU	EM	303 A	Y	1-395	PDB
8OIR	EM	310 A	AY	1-395	PDB
8OIS	EM	300 A	AY	1-395	PDB
AF-Q92665-F1	Predicted				AlphaFoldDB

338 variants for Q92665

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1158530189 CA387915309	2	F>C		No	ClinGen Ensembl
rs759755257 CA6959552	2	F>V		No	ClinGen ExAC TOPMed gnomAD
CA387915299 rs1292149376	3	P>S		No	ClinGen TOPMed
rs1458886459 CA387915291	4	R>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs777069421 CA6959551	4	R>T		No	ClinGen ExAC TOPMed
rs771232105 CA6959550	5	V>F		No	ClinGen ExAC TOPMed gnomAD
CA6959549 rs747268164	7	T>A		No	ClinGen ExAC gnomAD
CA387915249 rs1449063869	7	T>K		No	ClinGen gnomAD
CA6959543 rs745589744	10	P>L		No	ClinGen ExAC gnomAD
rs745589744 CA6959544	10	P>R		No	ClinGen ExAC gnomAD
CA6959545 rs185925279	10	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1566113976 CA387915208	11	L>V		No	ClinGen Ensembl
rs780985983 CA6959542	12	R>C		No	ClinGen ExAC gnomAD
CA6959541 rs756862669	12	R>L		No	ClinGen ExAC gnomAD
CA6959540 rs751181261	13	P>L		No	ClinGen ExAC gnomAD
CA387915185 rs1249383608	13	P>S		No	ClinGen gnomAD
CA248355340 rs201928058	14	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen 1000Genomes NCI-TCGA TOPMed gnomAD
rs1276251312 CA387915171	14	L>H		No	ClinGen gnomAD
rs1276251312 CA387915169	14	L>P		No	ClinGen gnomAD
CA6959538 rs757842607	16	R>C		No	ClinGen ExAC gnomAD
rs757842607 CA387915150	16	R>G		No	ClinGen ExAC gnomAD
CA387915147 rs1237002206	16	R>H		No	ClinGen TOPMed
rs1370419199 CA387915134	17	H>P		No	ClinGen TOPMed gnomAD
CA6959537 rs752258768	18	P>R		No	ClinGen ExAC gnomAD
rs765606634 CA387915110	19	L>V		No	ClinGen ExAC TOPMed gnomAD
CA6959535 rs754218007	20	S>F		No	ClinGen ExAC TOPMed gnomAD
CA6959534 rs754218007	20	S>Y		No	ClinGen ExAC TOPMed gnomAD
CA248355320 rs1017191960	24	P>L		No	ClinGen TOPMed
TCGA novel	25	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs761174341 CA6959532	25	E>G		No	ClinGen ExAC gnomAD
CA387915025 rs1439577746	26	T>A		No	ClinGen gnomAD
CA6959531 rs773551308	28	A>T		No	ClinGen ExAC TOPMed gnomAD
rs772400596 CA6959530	30	A>G		No	ClinGen ExAC gnomAD
CA387914966 rs1593281557	31	I>V		No	ClinGen Ensembl
CA387914957 rs1249614377	32	M>L		No	ClinGen TOPMed gnomAD
CA387914944 rs1181371399	33	L>P		No	ClinGen gnomAD
rs774498966 CA387914922	37	R>L		No	ClinGen ExAC TOPMed gnomAD
rs774498966 CA6959528	37	R>P		No	ClinGen ExAC TOPMed gnomAD
CA387914924 rs1462409510	37	R>W		No	ClinGen gnomAD
rs1343907371 CA387914916	38	H>R		No	ClinGen gnomAD
rs1360825653 CA387914910	39	G>E		No	ClinGen TOPMed
rs1256053876 CA387914913	39	G>R		No	ClinGen gnomAD
CA6959525 rs149961906	40	T>I		No	ClinGen ESP ExAC gnomAD
rs1397377542 CA387914907	40	T>P		No	ClinGen TOPMed gnomAD
CA6959523 rs770690567	43	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA387914887 rs1593281518	43	Y>D		No	ClinGen Ensembl
rs1310271801 CA387914880	44	R>C		No	ClinGen gnomAD
rs1310271801 CA387914882	44	R>G		No	ClinGen gnomAD
CA6959521 rs777341731	44	R>L		No	ClinGen ExAC gnomAD
rs758084407 CA6959520	45	S>G		No	ClinGen ExAC gnomAD
rs752101185 CA6959519	45	S>I		No	ClinGen ExAC gnomAD
rs1031367593 CA248355257	46	S>L		No	ClinGen TOPMed
CA6959517 rs754489555	47	A>S		No	ClinGen ExAC gnomAD
TCGA novel	48	L>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs372300050 CA6959515	50	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA6959512 rs371649042	51	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA6959511 rs762115044	51	R>L		No	ClinGen ExAC TOPMed gnomAD
rs371649042 CA6959513	51	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs556043646 CA248351989	54	N>S		No	ClinGen 1000Genomes gnomAD
rs764279977 CA6959489	55	N>D		No	ClinGen ExAC gnomAD
rs764279977 CA387914446	55	N>Y		No	ClinGen ExAC gnomAD
rs762953392 CA6959488	57	Q>R		No	ClinGen ExAC gnomAD
CA6959487 rs775561550	58	R>*		No	ClinGen ExAC gnomAD
rs539542256 CA248351981	58	R>I		No	ClinGen 1000Genomes
rs773065063 CA6959485	59	Y>*		No	ClinGen ExAC TOPMed gnomAD
CA6959486 rs766257255	59	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs139126960 CA6959483	62	T>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1263630118 CA387914400	62	T>P		No	ClinGen TOPMed
rs1201470082 CA387914388	64	S>G		No	ClinGen TOPMed
rs1279309120 CA387914385	64	S>N		No	ClinGen gnomAD
rs1321438581 CA387914382	64	S>R		No	ClinGen TOPMed gnomAD
rs1187879611 CA387914371	66	I>N		No	ClinGen TOPMed
rs774052260 CA6959479	67	C>S		No	ClinGen ExAC TOPMed gnomAD
rs768423504 CA6959478	67	C>Y		No	ClinGen ExAC gnomAD
CA387914361 rs1373682249	68	S>G		No	ClinGen gnomAD
rs1220960619 CA387914358	68	S>N		No	ClinGen Ensembl
CA6959477 rs748745900	69	K>T		No	ClinGen ExAC gnomAD
rs892007225 CA248351872	71	D>G		No	ClinGen gnomAD
rs779730647 CA6959476	72	K>R		No	ClinGen ExAC TOPMed gnomAD
rs1244500429 CA387914324	73	Q>*		No	ClinGen gnomAD
CA6959475 rs756646860	73	Q>P		No	ClinGen ExAC TOPMed gnomAD
rs746344175 CA6959474	76	R>*		No	ClinGen ExAC TOPMed gnomAD
CA387914303 rs868622225	76	R>P		No	ClinGen TOPMed gnomAD
rs868622225 CA248351860	76	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA248351859 rs17856655	80	T>I		No	ClinGen Ensembl
rs960600173 CA248351843	82	K>M		No	ClinGen TOPMed gnomAD
CA387914266 rs960600173	82	K>R		No	ClinGen TOPMed gnomAD
CA387914255 rs1407478038	83	E>D		No	ClinGen TOPMed gnomAD
CA387914252 rs1174520102	84	T>A		No	ClinGen gnomAD
rs757626748 CA6959472	84	T>I		No	ClinGen ExAC gnomAD
CA387914245 rs1229425973	85	S>*		No	ClinGen TOPMed gnomAD
CA387914244 rs1229425973	85	S>L		No	ClinGen TOPMed gnomAD
rs200566842 CA248351816	86	E>G		No	ClinGen 1000Genomes
CA6959468 rs201183404	88	Q>R		No	ClinGen 1000Genomes ExAC gnomAD
rs200426663 CA248351792	89	D>G		No	ClinGen 1000Genomes
CA6959467 rs150773124	90	S>G		No	ClinGen ESP ExAC TOPMed
CA6959466 rs765272512	90	S>N		No	ClinGen ExAC gnomAD
rs150773124 CA248351780	90	S>R		No	ClinGen ESP ExAC TOPMed
rs759664412 CA6959465	91	E>K		No	ClinGen ExAC gnomAD
CA387914194 rs1369735166	93	E>K		No	ClinGen gnomAD
rs368046468 CA6959463	95	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs774026133 CA6959461	96	K>E		No	ClinGen ExAC TOPMed gnomAD
rs1247874714 CA387914132	101	G>D		No	ClinGen gnomAD
rs201935274 CA248351661	104	K>R		No	ClinGen 1000Genomes
rs768370555 CA6959460	106	M>T		No	ClinGen ExAC TOPMed gnomAD
rs1482243689 CA387914087	108	V>I		No	ClinGen gnomAD
rs199933450 CA6959459	110	L>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA387914064 rs1270405301	111	S>N		No	ClinGen TOPMed
CA387914058 rs1206084137	112	T>A		No	ClinGen gnomAD
CA387914021 rs1192930304	114	N>S		No	ClinGen gnomAD
rs1479201207 CA387914008	115	V>L		No	ClinGen TOPMed
CA6959458 rs775319985	116	R>*	Variant assessed as Somatic; 0.000231 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs769404257 CA6959457	116	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs548881414 CA6959455	117	T>R		No	ClinGen 1000Genomes ExAC gnomAD
CA6959456 rs142114244	117	T>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	118	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1213088369 CA387913947	120	P>S		No	ClinGen gnomAD
rs1566112637 CA387913924	122	K>E		No	ClinGen Ensembl
rs747350850 CA6959453	123	R>G		No	ClinGen ExAC gnomAD
rs778143647 CA6959452	125	P>L		No	ClinGen ExAC gnomAD
CA387913868 rs1315848332	125	P>T		No	ClinGen TOPMed gnomAD
CA6959451 rs139886992	126	L>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs17851966 CA248351602	132	T>A		No	ClinGen Ensembl
CA248351587 rs773340932	134	G>D		No	ClinGen Ensembl
rs755050072 CA6959448	135	R>S		No	ClinGen ExAC TOPMed gnomAD
rs767427852 CA6959446	136	L>R		No	ClinGen ExAC gnomAD
rs753873034 CA6959447	136	L>V		No	ClinGen ExAC gnomAD
CA248351559 rs1047557890	137	R>*		No	ClinGen TOPMed
CA6959445 rs199554814	137	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs751326799 CA6959444	140	T>A		No	ClinGen ExAC TOPMed gnomAD
CA6959443 rs763947727	140	T>I		No	ClinGen ExAC gnomAD
TCGA novel	141	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs371403521 CA6959442	141	E>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA387913621 rs1306269815	142	Y>C		No	ClinGen Ensembl
CA6959441 rs775266887	143	A>S		No	ClinGen ExAC gnomAD
CA387913593 rs1293548902	144	P>S		No	ClinGen TOPMed
CA248351522 rs1050595636	145	K>R		No	ClinGen TOPMed
CA6959420 rs751427650	148	I>T		No	ClinGen ExAC gnomAD
rs764184452 CA6959419	149	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs1455836954 CA387912479	152	S>T		No	ClinGen gnomAD
rs570464939 CA6959416	154	E>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs376836833 CA248346980	160	S>T		No	ClinGen Ensembl
rs1448882563 CA387912367	161	A>T		No	ClinGen gnomAD
CA6959414 rs759142056	162	V>A		No	ClinGen ExAC gnomAD
CA6959413 rs770323321	165	S>C		No	ClinGen ExAC gnomAD
CA6959412 rs770323321	165	S>F		No	ClinGen ExAC gnomAD
CA6959411 rs553533266	167	P>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1264611418 CA387912218	171	Q>R		No	ClinGen gnomAD
rs773701873 CA387912203	172	T>I		No	ClinGen ExAC gnomAD
TCGA novel rs1593276748 CA387912210	172	T>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Ensembl
rs773701873 CA6959410	172	T>R		No	ClinGen ExAC gnomAD
CA387912144 rs1361145095	177	L>P		No	ClinGen gnomAD
rs563448048 CA6959409	182	Q>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1365239821 CA387912071	183	Q>K		No	ClinGen gnomAD
CA248346917 rs137895732	184	H>R		No	ClinGen ESP TOPMed gnomAD
CA387912020 rs1304770587	185	E>K		No	ClinGen TOPMed
rs1293306798 CA387911941	187	E>A		No	ClinGen gnomAD
CA6959407 rs774724951	188	S>P		No	ClinGen ExAC TOPMed gnomAD
rs1166898229 CA387911888	190	A>T		No	ClinGen gnomAD
rs768886101 CA6959406	192	R>T		No	ClinGen ExAC gnomAD
rs1257610719 CA387911774	194	A>G		No	ClinGen TOPMed gnomAD
rs1257610719 CA387911771 COSM3955587	194	A>V	lung [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs190789123 CA6959405	196	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA6959404 rs780374344	196	R>Q		No	ClinGen ExAC gnomAD
CA6959403 rs187459666	197	P>L		No	ClinGen 1000Genomes ExAC gnomAD
rs1266666327 CA387911725	197	P>T		No	ClinGen gnomAD
rs746012267 CA6959402	198	K>Q		No	ClinGen ExAC gnomAD
rs774882489 CA6959390	201	F>L		No	ClinGen ExAC gnomAD
rs1335537372 CA387911293	203	N>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs768882571 CA248345908	205	I>L		No	ClinGen ExAC TOPMed gnomAD
rs1482618905 CA387911247	205	I>M		No	ClinGen gnomAD
CA6959389 rs768882571	205	I>V		No	ClinGen ExAC TOPMed gnomAD
CA6959388 rs749721896	207	D>H		No	ClinGen ExAC gnomAD
rs749721896 CA387911216	207	D>N		No	ClinGen ExAC gnomAD
CA387911202 rs1224625099	207	D>V		No	ClinGen gnomAD
CA6959387 rs373481473	208	M>T		No	ClinGen ESP ExAC gnomAD
CA248345881 rs536332780	210	V>A		No	ClinGen Ensembl
CA248345887 rs1011600902	210	V>L		No	ClinGen TOPMed
CA387911089 rs1286832143	212	R>G		No	ClinGen gnomAD
rs1228233832 CA387911051	213	S>C		No	ClinGen gnomAD
rs1309347819 CA387911019	215	T>A		No	ClinGen TOPMed gnomAD
rs779757365 CA6959385	215	T>I		No	ClinGen ExAC gnomAD
CA387910994 rs781452553	216	A>G		No	ClinGen ExAC gnomAD
rs781452553 CA6959384	216	A>V		No	ClinGen ExAC gnomAD
rs1319818083 CA387910956	218	V>I		No	ClinGen TOPMed
CA248345859 rs757451497	219	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs757451497 CA6959383	219	R>G		No	ClinGen ExAC TOPMed gnomAD
rs748075331 CA6959382	219	R>H		No	ClinGen ExAC TOPMed gnomAD
CA387910893 rs1386449506	221	R>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs754722524 CA6959380	223	E>G		No	ClinGen ExAC gnomAD
CA387910812 rs377071174	225	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA6959378 rs377071174	225	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
COSM3936326 rs370481725 CA6959379	225	R>W	oesophagus [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs1243190809 CA387910802	226	I>L		No	ClinGen TOPMed gnomAD
TCGA novel	228	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1463043146 CA387910702	229	D>E		No	ClinGen gnomAD
rs755781376 CA6959377	229	D>G		No	ClinGen ExAC gnomAD
CA248345824 rs867547426	229	D>N		No	ClinGen Ensembl
rs749899603 CA6959376	232	Y>C		No	ClinGen ExAC gnomAD
rs201720205 CA6959375	233	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA387910605 rs1474695489	233	D>H		No	ClinGen TOPMed
rs761364957 CA6959374	234	N>S		No	ClinGen ExAC gnomAD
CA6959373 rs774829178	236	P>T		No	ClinGen ExAC TOPMed gnomAD
rs764730195 CA6959372	237	G>V		No	ClinGen ExAC gnomAD
rs775938052 CA6959370	241	T>A		No	ClinGen ExAC gnomAD
CA387910380 rs1854421	241	T>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6959369 VAR_052049 rs1854421	241	T>M		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA387910378 rs1854421	241	T>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	243	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6959365 rs747149685	244	L>R		No	ClinGen ExAC gnomAD
rs377188729 CA6959363	245	K>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA6959361 rs779933917	247	R>K		No	ClinGen ExAC
CA387910213 rs1278856110	247	R>W		No	ClinGen TOPMed
rs1417921468 CA387908624	248	K>N		No	ClinGen gnomAD
CA6959353 rs751085839	248	K>R		No	ClinGen ExAC TOPMed gnomAD
CA387908637 rs751085839	248	K>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	249	N>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs776228534 CA248344174	250	I>L		No	ClinGen TOPMed gnomAD
CA387908587 rs776228534	250	I>V		No	ClinGen TOPMed gnomAD
CA6959352 rs764451428	251	F>Y		No	ClinGen ExAC gnomAD
rs373475702 CA6959351	253	G>E		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	255	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6959349 rs555429143	255	R>K		No	ClinGen 1000Genomes ExAC gnomAD
CA6959348 rs760035202	257	N>I		No	ClinGen ExAC TOPMed gnomAD
CA387908420 rs1348057232	257	N>K		No	ClinGen TOPMed
CA387908422 rs760035202	257	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1227302706 CA387908418	258	I>V		No	ClinGen TOPMed
rs1427456813 CA387908350	261	M>L		No	ClinGen TOPMed gnomAD
CA387908339 rs1336153973	261	M>T		No	ClinGen TOPMed
CA387908319 rs1247356383	262	M>T		No	ClinGen TOPMed
rs1388979137 CA387908308	263	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
TCGA novel	263	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs776987282 CA6959347	265	T>N		No	ClinGen ExAC gnomAD
rs978404258 CA248344115	266	K>E		No	ClinGen TOPMed
CA248344114 rs199601303	268	A>E		No	ClinGen 1000Genomes
CA248344108 rs185897036	270	E>K		No	ClinGen 1000Genomes TOPMed gnomAD
CA6959331 rs750985643	274	S>P		No	ClinGen ExAC gnomAD
CA6959329 rs757895673	275	P>L		No	ClinGen ExAC TOPMed gnomAD
CA6959328 rs753233954	277	L>V		No	ClinGen ExAC TOPMed gnomAD
CA6959326 rs759910674	278	W>*		No	ClinGen ExAC TOPMed gnomAD
CA6959327 rs759910674	278	W>C		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	278	W>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1226276228 CA387906550	279	D>G		No	ClinGen gnomAD
CA248341432 rs13508	279	D>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
VAR_061812 CA6959324 rs13508	279	D>N		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs13508 CA6959325	279	D>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6959323 rs760983454	280	V>M		No	ClinGen ExAC TOPMed gnomAD
CA387906498 rs1443967053	281	E>G		No	ClinGen gnomAD
rs1459362671 CA387906475	282	F>V		No	ClinGen gnomAD
CA387906433 rs1356902948	283	A>V		No	ClinGen gnomAD
CA387906397 rs1377154367	285	Q>*		No	ClinGen TOPMed
rs1448580389 CA387906351	287	A>T		No	ClinGen TOPMed
CA387906313 rs1407552989	290	N>H		No	ClinGen gnomAD
rs150802943 CA6959320	291	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs139173700 CA6959319	293	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA387906241 rs139173700	293	P>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs769729955 CA6959318	294	L>F		No	ClinGen ExAC TOPMed gnomAD
rs745605839 CA6959317	294	L>P		No	ClinGen ExAC gnomAD
rs567622797 CA6959316	296	N>K		No	ClinGen 1000Genomes ExAC gnomAD
rs770531505 CA6959315	297	G>E		No	ClinGen ExAC gnomAD
CA248341377 rs201048583	300	E>D		No	ClinGen 1000Genomes gnomAD
CA387906027 rs1458381086	301	L>Q		No	ClinGen TOPMed
rs202154364 CA248341376	302	I>L		No	ClinGen 1000Genomes
rs375923229 CA6959314	306	K>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	307	E>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1182334009 CA387905793	310	L>P		No	ClinGen TOPMed
rs1225094091 CA387905760	311	W>C		No	ClinGen gnomAD
CA387905765 rs1284745460	311	W>L		No	ClinGen gnomAD
rs1593447191 CA387905683	315	I>V		No	ClinGen Ensembl
CA6959311 rs757919004	317	N>S		No	ClinGen ExAC TOPMed gnomAD
rs771635473 CA6959293	320	G>D		No	ClinGen ExAC gnomAD
CA6959292 rs747642692	322	D>N		No	ClinGen ExAC gnomAD
CA6959291 rs557779396	324	D>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
CA6959290 rs146322897	325	G>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs1300836347 CA388004641	325	G>S		No	ClinGen TOPMed
rs1433256189 CA388004612	327	E>D		No	ClinGen TOPMed gnomAD
rs1364125309 CA388004594	329	H>R		No	ClinGen gnomAD
rs372222169 CA6959288	330	E>*		No	ClinGen ESP ExAC gnomAD
rs372222169 CA388004585	330	E>K		No	ClinGen ESP ExAC gnomAD
CA388004570 rs1488010093	331	H>R		No	ClinGen TOPMed
CA388004558 rs1427848862	332	I>T		No	ClinGen TOPMed gnomAD
rs368447180 CA6959286	332	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA6959284 rs77896392	337	H>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1158695136 CA388004489	338	L>R		No	ClinGen gnomAD
rs760756520 CA6959282	342	P>A		No	ClinGen ExAC gnomAD
rs866083905 CA248992366	343	K>E		No	ClinGen Ensembl
CA388004428 rs1490752119	344	Q>R		No	ClinGen gnomAD
CA388004421 rs1271842004	345	G>R		No	ClinGen gnomAD
CA388004414 rs1420461190	345	G>V		No	ClinGen TOPMed
rs1226143038 CA388004400	347	I>F		No	ClinGen gnomAD
rs867328411 CA248992365	347	I>N		No	ClinGen Ensembl
rs763077902 CA6959281	348	R>C		No	ClinGen ExAC TOPMed gnomAD
rs766229410 CA6959279	348	R>H		No	ClinGen ExAC TOPMed gnomAD
rs766229410 CA6959280	348	R>L		No	ClinGen ExAC TOPMed gnomAD
rs763077902 CA248992364	348	R>S		No	ClinGen ExAC TOPMed gnomAD
rs1216862252 CA388004378	349	H>P		No	ClinGen gnomAD
CA6959276 rs34392264	351	M>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs374234655 CA6959278	351	M>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA6959277 rs374234655	351	M>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs761521934 CA6959275	355	T>S		No	ClinGen ExAC TOPMed gnomAD
rs768272050 CA6959273	356	C>Y		No	ClinGen ExAC gnomAD
CA248992363 rs371339203	357	G>S		No	ClinGen ESP TOPMed
CA388004258 rs1461498908	360	K>Q		No	ClinGen TOPMed gnomAD
rs748878566 CA6959272	360	K>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	361	N>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs780545918 CA6959271	362	P>A		No	ClinGen ExAC gnomAD
CA388004237 rs780545918	362	P>T		No	ClinGen ExAC gnomAD
CA388004226 rs1246875402	363	Y>H		No	ClinGen TOPMed
rs1428313616 CA388004217	364	L>I		No	ClinGen gnomAD
rs920342140 CA388004204	365	S>C		No	ClinGen TOPMed gnomAD
CA248992362 rs920342140	365	S>G		No	ClinGen TOPMed gnomAD
rs201924592 CA6959268	365	S>N		No	ClinGen ExAC TOPMed gnomAD
CA388004207 rs920342140	365	S>R		No	ClinGen TOPMed gnomAD
TCGA novel	366	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA388004182 rs1194894896	366	V>F		No	ClinGen TOPMed gnomAD
CA388004191 rs1194894896	366	V>I		No	ClinGen TOPMed gnomAD
rs757681509 CA6959267	371	E>G		No	ClinGen ExAC TOPMed gnomAD
CA388004102 rs1593438737	372	H>R		No	ClinGen Ensembl
rs751760079 CA6959265	375	W>C		No	ClinGen ExAC gnomAD
rs752134211 CA6959264	376	F>L		No	ClinGen ExAC gnomAD
rs3308 CA248992360	378	N>D		No	ClinGen Ensembl
rs1305079288	379	Y>*		No	gnomAD
rs535639095 CA6959263	379	Y>C		No	ClinGen 1000Genomes ExAC gnomAD
CA388004009 rs1237262542	379	Y>H		No	ClinGen TOPMed
TCGA novel	380	F>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs752785049 CA388004001	380	F>L		No	ClinGen ExAC gnomAD
CA6959262 rs752785049	380	F>V		No	ClinGen ExAC gnomAD
CA388003968 rs1399039952	382	E>G		No	ClinGen Ensembl
TCGA novel	385	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1405348537 CA388003937	385	D>H		No	ClinGen gnomAD
TCGA novel	388	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA388003875 rs1416558959	390	S>N		No	ClinGen TOPMed
CA6959257 rs142646038	391	N>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs761761204 CA6959256	391	N>S		No	ClinGen ExAC gnomAD
CA388003854 rs1593438682	392	I>T		No	ClinGen Ensembl
CA6959255 rs774145864	392	I>V		No	ClinGen ExAC TOPMed gnomAD
CA388003835 rs1239701007	394	F>L		No	ClinGen TOPMed gnomAD
CA6959253 rs762497106	395	N>S		No	ClinGen ExAC TOPMed gnomAD

No associated diseases with Q92665

No regional properties for Q92665

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q92665

Functions

		Description
EC Number
Subcellular Localization	Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
mitochondrial inner membrane	The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrial small ribosomal subunit	The smaller of the two subunits of a mitochondrial ribosome.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.

3 GO annotations of molecular function

Name	Definition
protein domain specific binding	Binding to a specific domain of a protein.
RNA binding	Binding to an RNA molecule or a portion thereof.
structural constituent of ribosome	The action of a molecule that contributes to the structural integrity of the ribosome.

1 GO annotations of biological process

Name	Definition
mitochondrial translation	The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code.

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MFPRVSTFLP	LRPLSRHPLS	SGSPETSAAA	IMLLTVRHGT	VRYRSSALLA	RTKNNIQRYF
70	80	90	100	110	120
GTNSVICSKK	DKQSVRTEET	SKETSESQDS	EKENTKKDLL	GIIKGMKVEL	STVNVRTTKP
130	140	150	160	170	180
PKRRPLKSLE	ATLGRLRRAT	EYAPKKRIEP	LSPELVAAAS	AVADSLPFDK	QTTKSELLSQ
190	200	210	220	230	240
LQQHEEESRA	QRDAKRPKIS	FSNIISDMKV	ARSATARVRS	RPELRIQFDE	GYDNYPGQEK
250	260	270	280	290	300
TDDLKKRKNI	FTGKRLNIFD	MMAVTKEAPE	TDTSPSLWDV	EFAKQLATVN	EQPLQNGFEE
310	320	330	340	350	360
LIQWTKEGKL	WEFPINNEAG	FDDDGSEFHE	HIFLEKHLES	FPKQGPIRHF	MELVTCGLSK
370	380	390
NPYLSVKQKV	EHIEWFRNYF	NEKKDILKES	NIQFN