Q924S7
Gene name |
Spred2 |
Protein name |
Sprouty-related, EVH1 domain-containing protein 2 |
Names |
Spred-2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:114716 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q924S7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q924S7-F1 | Predicted | AlphaFoldDB |
25 variants for Q924S7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389145122 | 29 | G>V | No | EVA | |
| rs3402057499 | 39 | S>R | No | EVA | |
| rs3389142619 | 42 | G>D | No | EVA | |
| rs3389156740 | 65 | K>N | No | EVA | |
| rs3389121768 | 125 | G>D | No | EVA | |
| rs3389145132 | 183 | Y>* | No | EVA | |
| rs3389156744 | 193 | R>W | No | EVA | |
| rs3389156714 | 222 | T>S | No | EVA | |
| rs3389137755 | 231 | P>L | No | EVA | |
| rs3389132613 | 238 | D>V | No | EVA | |
| rs3389150947 | 246 | Y>* | No | EVA | |
| rs3389141550 | 274 | D>V | No | EVA | |
| rs3389117293 | 276 | K>R | No | EVA | |
| rs3389117292 | 306 | D>G | No | EVA | |
| rs3401897779 | 312 | E>G | No | EVA | |
| rs3402057530 | 313 | N>K | No | EVA | |
| rs3402012174 | 315 | R>S | No | EVA | |
| rs3401285938 | 316 | G>A | No | EVA | |
| rs3401897778 | 316 | G>R | No | EVA | |
| rs3389117219 | 346 | M>T | No | EVA | |
| rs3389141585 | 362 | S>C | No | EVA | |
| rs3389141607 | 375 | A>S | No | EVA | |
| rs3389145150 | 382 | C>Y | No | EVA | |
| rs3389145153 | 390 | R>Q | No | EVA | |
| rs3389139197 | 391 | A>V | No | EVA |
No associated diseases with Q924S7
Functions
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasmic vesicle | A vesicle found in the cytoplasm of a cell. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| transport vesicle membrane | The lipid bilayer surrounding a transport vesicle. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| protein kinase binding | Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. |
| protein serine/threonine kinase inhibitor activity | Binds to and stops, prevents or reduces the activity of a protein serine/threonine kinase. |
| stem cell factor receptor binding | Binding to a stem cell factor receptor (SCFR), a type III transmembrane kinase receptor. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| negative regulation of epithelial to mesenchymal transition | Any process that decreases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. |
| negative regulation of ERK1 and ERK2 cascade | Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. |
| negative regulation of lens fiber cell differentiation | Any process that stops, prevents or reduces the frequency, rate or extent of lens fiber cell differentiation. |
| negative regulation of MAPK cascade | Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade. |
| negative regulation of peptidyl-threonine phosphorylation | Any process that decreases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine. |
| negative regulation of transforming growth factor beta receptor signaling pathway | Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway. |
| positive regulation of DNA damage response, signal transduction by p53 class mediator | Any process that activates, maintains or increases the rate of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage. |
| regulation of protein deacetylation | Any process that modulates the rate, frequency, or extent of protein deacetylation, the removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTEETHPDDD | SYIVRVKAVV | MTRDDSSGGW | FPQEGGGISR | VGVCKVMHPE | GNGRSGFLIH |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GERQKDKLVV | LECYVRKDLV | YTKANPTFHH | WKVDNRKFGL | TFQSPADARA | FDRGVRKAIE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DLIEGSTTSS | STLHNEAELG | DDDVFTTATD | SSSNSSQKRE | PTTRTISSPT | SCEHRKIYTL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DPYPMDHYHP | DQRLPRSYPQ | VTFPEDDEEI | VRINPREKIW | MTGYEDYRHA | PVRGKYLDTT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EDADSYVRFA | KGEVPKHEYT | YPYVDSSDFG | FGEDPKGSVI | KTQPPRAKSR | RRKENGERSR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| CVYCRDMFNH | EENRRGHCQD | APDAVRTCIR | RVSCMWCADS | MLYHCMSDPE | GDYTDPCSCD |
| 370 | 380 | 390 | 400 | ||
| TSDEKFCLRW | MALIALSFLA | PCMCCYLPLR | ACHRCGVMCR | CCGGKHKAAA |