Q92441

PR
Gene name
MET17 (KLLA0D04037g)
Protein name
Homocysteine/cysteine synthase
Names
O-acetylserine/O-acetylhomoserine sulfhydrylase, OAS-OAH SHLase, OAS-OAH sulfhydrylase
Species
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
KEGG Pathway
kla:KLLA0_D04037g
EC number
2.5.1.47: Transferring alkyl or aryl groups, other than methyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-52 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q92441

Entry ID Method Resolution Chain Position Source
AF-Q92441-F1 Predicted AlphaFoldDB

No variants for Q92441

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q92441

No associated diseases with Q92441

12 regional properties for Q92441

Type Name Position InterPro Accession
domain Protein kinase domain 1079 - 1346 IPR000719
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 1079 - 1337 IPR001245
domain Sema domain 27 - 516 IPR001627
repeat Plexin repeat 521 - 562 IPR002165
domain IPT domain 563 - 656 IPR002909-1
domain IPT domain 657 - 740 IPR002909-2
domain IPT domain 742 - 837 IPR002909-3
domain IPT domain 839 - 935 IPR002909-4
active_site Tyrosine-protein kinase, active site 1201 - 1213 IPR008266
domain PSI domain 520 - 563 IPR016201
binding_site Protein kinase, ATP binding site 1085 - 1111 IPR017441
domain Tyrosine-protein kinase, catalytic domain 1079 - 1338 IPR020635

Functions

Description
EC Number 2.5.1.47 Transferring alkyl or aryl groups, other than methyl groups
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
cysteine synthase activity Catalysis of the reaction: O3-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate.
O-acetylhomoserine aminocarboxypropyltransferase activity Catalysis of the reaction: O-acetyl-L-homoserine + methanethiol = L-methionine + acetate. Also reacts with other thiols and H2S, producing homocysteine or thioethers.
pyridoxal phosphate binding Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.

1 GO annotations of biological process

Name Definition
transsulfuration The interconversion of homocysteine and cysteine via cystathionine. In contrast with enteric bacteria and mammals, Saccharomyces cerevisiae has two transsulfuration pathways employing two separate sets of enzymes.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPSHFDTLQL HAGQEKTADA HNPRAVPIYA TTSYVFNDSK HGAQLFGLET PGYIYSRIMN
70 80 90 100 110 120
PTLDVLEKRL AALEGGIAAL ATSSGQAAQT LAVTGLAHTG DNIVSTSFLY GGTYNQFKVA
130 140 150 160 170 180
FKRLGIEARF VDGDKPEDFE KLFDEKTKAL YLESIGNPKY NVPDFEKIVA VAHKHGIPVV
190 200 210 220 230 240
VDNTFGAGGF FCQPIKYGAD IVTHSATKWI GGHGVTVGGV IIDSGKFPWK DYPEKFPQFS
250 260 270 280 290 300
QPSEGYHGLI FNDAFGPAAF IGHVRTELLR DLGPVLSPFA GFLLLQGLET LSLRGERHGS
310 320 330 340 350 360
NALKLAQYLE SSPYVSWVSY PGLPSHSHHE NAKKYLENGF GGVLSFGVKD LPNASEESDP
370 380 390 400 410 420
FKASGAQVVD NLKLASNLAN VGDSKTLVIA PYFTTHQQLT DEEKLASGVT KDLIRVSVGT
430 440
EFIDDIIADF EASFATVFNG QKPE