Q92377

PR
Gene name
mdm12
Protein name
Mitochondrial distribution and morphology protein 12
Names
Mitochondrial inheritance component mdm12
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPBC28F2.06c
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

41-177 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q92377

Entry ID Method Resolution Chain Position Source
AF-Q92377-F1 Predicted AlphaFoldDB

No variants for Q92377

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q92377

No associated diseases with Q92377

1 regional properties for Q92377

Type Name Position InterPro Accession
domain Synaptotagmin-like mitochondrial-lipid-binding domain 1 - 273 IPR031468

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion outer membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side
  • The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions
  • These foci are often found next to mtDNA nucleoids
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
ERMES complex A protein complex that links the endoplasmic reticulum with mitochondria and may have a role in promoting exchange of calcium and phospholipids between the two organelles.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
lipid binding Binding to a lipid.
mitochondrion-endoplasmic reticulum membrane tether activity The binding activity of a molecule that brings together a mitochondrion and an ER membrane either via membrane lipid binding or by interacting with a mitochondrial outer membrane protein, to establish or maintain the localization of the mitochondrion.

6 GO annotations of biological process

Name Definition
intermembrane phospholipid transfer The transport of phospholipids between membranes in which a phospholipid molecule is transported through an aqueous phase from the outer leaflet of a donor membrane to the outer leaflet of an acceptor membrane.
mitochondrial genome maintenance The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome.
mitochondrial membrane organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion.
mitochondrion-endoplasmic reticulum membrane tethering The attachment of a mitochondrion and an endoplasmic reticulum via molecular tethers that physically bridge their respective membranes and attach them to each other. The tethering may facilitate exchange of metabolites between the organelles.
phospholipid transport The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester.
protein insertion into mitochondrial outer membrane The process comprising the insertion of proteins from outside the organelle into the mitochondrial outer membrane, mediated by large outer membrane translocase complexes.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSIDFDWSKL DSELEAKVLH LLEGQVSNLS LPSYIKHLKV VDFHFGKVSP QITIQEIGDP
70 80 90 100 110 120
DPQFYENEAF ELANQELEGD QCSRNNVSPV LTDLPPYAAE HPFSRLAYFN PAFNSPGILS
130 140 150 160 170 180
ASGLTSPIPE SRPSTPMDNH QERDRSNDFQ VTAHVSYDGD ANLSLEAVLS MNYPNSEFAV
190 200 210 220 230 240
LPFKLSFIRI SIDAIAVLAK MGKRTHLCFV DTLLHGTGEH ASSVIRDLTV ESIIGESNKQ
250 260 270
LLKNVAKVEK FVSEKVKRII EDELVWPSYI TIE