Q92355

PR
Gene name
sen1 (SPAC6G9.10c)
Protein name
Helicase sen1
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC6G9.10c
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

721-934 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q92355

Entry ID Method Resolution Chain Position Source
AF-Q92355-F1 Predicted AlphaFoldDB

26 variants for Q92355

Variant ID(s) Position Change Description Diseaes Association Provenance
I_3267517_C_A 3 E>D No Jeffares_SNPs
I_3267266_A_G 87 F>S No Jeffares_SNPs
I_3267104_T_G 141 Y>S No Jeffares_SNPs
I_3267087_C_T 147 A>T No Jeffares_SNPs
I_3266972_T_C 185 K>R No Jeffares_SNPs
I_3266931_C_T 199 A>T No Jeffares_SNPs
I_3266556_T_C 324 T>A No Jeffares_SNPs
I_3266385_C_A 381 A>S No Jeffares_SNPs
I_3265986_T_G 514 T>P No Jeffares_SNPs
I_3265920_T_C 536 I>V No Jeffares_SNPs
I_3265859_A_G 556 F>S No Jeffares_SNPs
I_3265809_T_C 573 I>V No Jeffares_SNPs
I_3265448_A_G 693 L>S No Jeffares_SNPs
I_3265390_G_C 712 D>E No Jeffares_SNPs
I_3265365_T_C 721 T>A No Jeffares_SNPs
I_3265283_G_A 748 T>I No Jeffares_SNPs
I_3265160_T_C 789 Q>R No Jeffares_SNPs
I_3265130_G_A 799 S>F No Jeffares_SNPs
I_3264558_C_T 990 V>I No Jeffares_SNPs
I_3264438_C_T 1030 A>T No Jeffares_SNPs
I_3264356_C_T 1057 R>H No Jeffares_SNPs
I_3263966_C_T 1187 S>N No Jeffares_SNPs
I_3263498_T_A 1343 Q>L No Jeffares_SNPs
I_3263222_G_A 1435 S>F No Jeffares_SNPs
I_3263061_G_T 1489 L>I No Jeffares_SNPs
I_3262646_C_T 1627 G>E No Jeffares_SNPs

No associated diseases with Q92355

5 regional properties for Q92355

Type Name Position InterPro Accession
domain Helicase Sen1, N-terminal 55 - 304 IPR024481-1
domain Helicase Sen1, N-terminal 400 - 693 IPR024481-2
domain DNA2/NAM7 helicase, helicase domain 1129 - 1415 IPR041677
domain DNA2/NAM7 helicase-like, C-terminal 1422 - 1617 IPR041679
domain Upf1-like, C-terminal helicase domain 1447 - 1633 IPR047187

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
chromatin The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
nuclear body Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

6 GO annotations of molecular function

Name Definition
5'-3' DNA/RNA helicase activity Unwinding of a DNA/RNA duplex in the 5' to 3' direction, driven by ATP hydrolysis.
5'-3' RNA helicase activity Unwinding of an RNA helix in the 5' to 3' direction, driven by ATP hydrolysis.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
hydrolase activity Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
RNA binding Binding to an RNA molecule or a portion thereof.
transcription termination site sequence-specific DNA binding Binding to a sequence of DNA that promotes termination by RNA polymerase. The transcribed region might be described as a gene, cistron, or operon.

5 GO annotations of biological process

Name Definition
mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.
termination of RNA polymerase II transcription A transcription termination process that completes the production of a primary RNA polymerase II transcript.
termination of RNA polymerase III transcription A transcription termination process that completes the production of a primary RNA polymerase II transcript. RNA polymerase III has an intrinsic ability to terminate transcription upon incorporation of at least 4 contiguous U residues.
tRNA processing The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAENLSDQDC FEKLSSSKEG QHWFCSGLLT QYIQPTFFWF AHDETPSFKW VLNAYHERLR
70 80 90 100 110 120
SCTSCIQAYY ELRNESLAKG SYSFTGFSIT DLQEKWNKWD IIRVLEDFKA LEDETIDFTS
130 140 150 160 170 180
LPCLIFETLL NPKLFTCKNI YKNAIDAFNG LLSDWCSNIF LPGYLLFFYE ASHPDVLEWV
190 200 210 220 230 240
HSFFKENTEI RISSATVDAV FNTVVFESQN SSDSDCNFVS ISSPEFWERT YMFLELLPLQ
250 260 270 280 290 300
SITAACESIL KDYLLNLVKT SESLSSQQMS CLRICCNSSS FWSAADSFKE VSSFLKNLLK
310 320 330 340 350 360
NVTATPFEVS DMNWAYIIAS FFRTCLNDFV SVFPEWLKGF VEEKRTIGFI IYSVLDALFD
370 380 390 400 410 420
LLSLDYSSPS FLNNTLSLMN ANSITILQDY PEYMLKLRLH SLLYDIAFIS WSHKAITKNP
430 440 450 460 470 480
SFVFDPSYEL SPFWKLDNLQ EEKISDVLFS KISSCCFAHD IEISENSTPS GTMVQFAELW
490 500 510 520 530 540
QVMSEYISGF LKGFSEKSST EISNMLGDSS KFDTVVSFLL SPTQPLYVSA FHIVQIITNC
550 560 570 580 590 600
TKNRNEALKK LVAMDFRGIV HGLADAVLNW QSILSFFPAL RIMRFLSITN KSLSSDNSAF
610 620 630 640 650 660
TENDIPTLGA YWQCIWNILD LVFSNVARWS LNNPADTVKA LMKLTLKFVD DLFQNDGIFI
670 680 690 700 710 720
KLLAKFDSLI LLGETSESLF SFIMWLKIND LELRGIVINS LCKLFTKFSN FDYLFEDRTV
730 740 750 760 770 780
TFLTDFIIRK QKAHLSADQC KQLANVLTQA SPEAKTVLEQ HRLSEMRKTK KQTELTNSAH
790 800 810 820 830 840
VIKPSPTPQI TVKQNTTKSS SAPRMGMLEQ LKQEYLTKRN FESKLKSSAV SSRKPTFNEV
850 860 870 880 890 900
KPANLLAEDL SDNEDDIDRK QGLFSLAKAN KIPEIRQQER RQVQLLSNST IKMHPSQIRM
910 920 930 940 950 960
MTNRNVANVK ARLFPSMTDF YKEILSWEPA NQSPNPVLKF HKLDGKIIDS FKTVEHYMEV
970 980 990 1000 1010 1020
LQPMIFMECW SQIQSTKLDL KFSPVEGIMV ERTAVNNFVD IGVSVAPKDL YGYPLYDTEV
1030 1040 1050 1060 1070 1080
VSLAFNKEDA SSMKGLCCFA KVERIVRQTN GVLVVLRTLP SMEILNKLQG NCALWFLKLT
1090 1100 1110 1120 1130 1140
NLATFTRQYA GIRGLPYFHL ADDIIRARPC SQPVKHSSSE IKAAMKRYQV NEPQAKAIMC
1150 1160 1170 1180 1190 1200
ALDNNGFTLI QGPPGTGKTK TIIGIISALL VDLSRYHITR PNQQSKSTES KQQILLCAPS
1210 1220 1230 1240 1250 1260
NAAVDEVLLR LKRGFLLENG EKYIPRVVRI GNPETINVSV RDLSLEYQTE KQLLEVNQGA
1270 1280 1290 1300 1310 1320
IDLGSLQELT RWRDTFYDCI QKIEELEKQI DVARDVAEDT KSLGKELQNK INEKNLAEQK
1330 1340 1350 1360 1370 1380
VEELQSQSFT KNKEVDLLRK KAQKAILKQA DVVCATLSGS GHDLVAHSSL NFSTVIIDEA
1390 1400 1410 1420 1430 1440
AQAVELDTII PLRYGAKKCI LVGDPNQLPP TVLSKKAASL NYSQSLFVRI QKNFSNQMCL
1450 1460 1470 1480 1490 1500
LSIQYRMHPD ISHFPSKKFY DSRLEDGDNM AEKTQQVWHV NPKFTQYRLF DVRGKERTSN
1510 1520 1530 1540 1550 1560
TMSTYNLEEV EYLVNMVDEL LNKFPDVNFT GRIGVITPYR SQLHELRRAF KVKYGKSFMS
1570 1580 1590 1600 1610 1620
TIDIQTVDGF QGQEKDIIFF SCVKSYSKHG IGFLRDFRRL NVALTRARSS LLIIGNMETL
1630 1640 1650 1660 1670 1680
KTDDLWGSLV DDALSRKLVE SPHIDSEGRL ITISRTSEKR MKNEEFVEPP SKKLANSEPS
KEIRQRS