Q92352

PR
Gene name
arc4 (arp20, SPAC6G9.07c)
Protein name
Actin-related protein 2/3 complex subunit 4
Names
Arp2/3 complex 20 kDa, p20-ARC
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC6G9.07c
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-83 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

7 structures for Q92352

Entry ID Method Resolution Chain Position Source
3DWL X-ray 378 A F/K 1-168 PDB
6W17 EM 390 A F 1-168 PDB
6W18 EM 420 A F 1-168 PDB
8E9B EM 350 A F 1-168 PDB
8UXW EM 270 A F 1-168 PDB
8UXX EM 320 A F 1-168 PDB
AF-Q92352-F1 Predicted AlphaFoldDB

No variants for Q92352

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q92352

No associated diseases with Q92352

No regional properties for Q92352

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q92352

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytoskeleton, actin patch
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
actin cortical patch An endocytic patch that consists of an actin-containing structure found at the plasma membrane in cells; formed of networks of branched actin filaments that lie just beneath the plasma membrane and assemble, move, and disassemble rapidly. An example of this is the actin cortical patch found in Saccharomyces cerevisiae.
Arp2/3 protein complex A stable protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5), and functions in the nucleation of branched actin filaments.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name Definition
actin filament binding Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.

5 GO annotations of biological process

Name Definition
actin cortical patch assembly Assembly of an actin cortical patch, a discrete actin-containing structure found at the plasma membrane of fungal cells.
actin filament polymerization Assembly of actin filaments by the addition of actin monomers to a filament.
Arp2/3 complex-mediated actin nucleation The actin nucleation process in which actin monomers combine to form a new branch on the side of an existing actin filament; mediated by the Arp2/3 protein complex and its interaction with other proteins.
endocytosis A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
regulation of actin filament polymerization Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSNTLRPYLN AVRSTLTASL ALEEFSSEIV ERQSQPEVEV GRSPEILLKP LVVSRNEQEQ
70 80 90 100 110 120
CLIESSVNSV RFSIRIKQVD EIERILVRKF MQFLMGRAES FFILRRKPVQ GYDISFLITN
130 140 150 160
YHTEEMLKHK LVDFIIEFME EVDAEISEMK LFLNGRARLV AETYLSCF