AiPD: Autoinhibited Protein Database

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

85-157 (Predicted disordered autoinhibitory region) PR

85-157 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q921I6-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388486841	44	S>I	No	EVA
rs257628241	48	V>G	No	EVA
rs3388486934	48	V>L	No	EVA
rs3388487521	49	D>N	No	EVA
rs3388486571	56	N>S	No	EVA
rs3388486645	65	D>E	No	EVA
rs3390251340	72	T>S	No	EVA
rs3388488466	134	E>D	No	EVA
rs3388486933	145	G>D	No	EVA
rs3388487051	147	T>I	No	EVA
rs3388488493	173	N>I	No	EVA
rs3388487646	201	F>I	No	EVA
rs3388488030	219	L>P	No	EVA
rs3388486688	237	F>I	No	EVA
rs214813266	261	T>M	No	EVA
rs3388490042	267	G>S	No	EVA
rs237536046	272	V>A	No	EVA
rs3388487743	290	R>P	No	EVA
rs3388490086	291	K>N	No	EVA
rs3388488228	307	G>V	No	EVA
rs3388487718	327	G>A	No	EVA
rs3388485097	348	G>R	No	EVA
rs3388486923	348	G>V	No	EVA
rs3388486928	371	T>A	No	EVA
rs3388487704	406	S>R	No	EVA
rs3388486839	435	D>Y	No	EVA
rs3388490149	483	I>V	No	EVA
rs3388487497	523	W>*	No	EVA
rs36264761	529	I>V	No	EVA
rs3388486563	542	S>F	No	EVA
rs3388490077	545	T>I	No	EVA
rs3388487714	552	N>S	No	EVA
rs3388486595	594	D>G	No	EVA
rs3388487673	597	D>N	No	EVA
rs245308639	615	A>T	No	EVA
rs3388487417	618	P>S	No	EVA
rs3388485150	645	P>S	No	EVA
rs3388487391	649	D>H	No	EVA
rs3388488227	680	D>G	No	EVA
rs3388490123	696	L>P	No	EVA
rs36640523	743	I>M	No	EVA
rs36909204	769	R>W	No	EVA
rs3390306503	777	Y>S	No	EVA
rs3388487768	922	K>R	No	EVA
rs3412117818	929	R>M	No	EVA
rs3388487665	943	S>L	No	EVA
rs227150280	945	D>E	No	EVA
rs3388487510	959	D>H	No	EVA

Type	Name	Position	InterPro Accession
domain	ZU5 domain	316 - 453	IPR000906
domain	SH3 domain	55 - 114	IPR001452-1
domain	SH3 domain	653 - 723	IPR001452-2
domain	SH3BP4, SH3 domain	59 - 110	IPR035456

		Description
EC Number
Subcellular Localization	Membrane, clathrin-coated pit Cytoplasmic vesicle, clathrin-coated vesicle Nucleus	Specifically associated with transferrin receptor-containing clathrin-coated pits and clathrin-coated vesicles May also localize to the nucleus (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
clathrin-coated pit	A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes.
clathrin-coated vesicle	A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

Name	Definition
GDP-dissociation inhibitor activity	Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding.
identical protein binding	Binding to an identical protein or proteins.
small GTPase binding	Binding to a small monomeric GTPase.

Name	Definition
cellular response to amino acid stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups.
endocytosis	A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
negative regulation of cell growth	Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
negative regulation of cell population proliferation	Any process that stops, prevents or reduces the rate or extent of cell proliferation.
negative regulation of GTPase activity	Any process that stops or reduces the rate of GTP hydrolysis by a GTPase.
negative regulation of TOR signaling	Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling.
positive regulation of autophagy	Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
protein localization to lysosome	A process in which a protein is transported to, or maintained in, a location within a lysosome.
regulation of catalytic activity	Any process that modulates the activity of an enzyme.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins