Q921C5
SS
Gene name |
Bicd2 (Kiaa0699) |
Protein name |
Protein bicaudal D homolog 2 |
Names |
Bic-D 2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:76895 |
EC number |
|
Protein Class |
|
Descriptions
Protein bicaudal D homolog 1 (BICD1) is a protein that regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex. Autoinhibition of BICD1 involves the C-terminal coiled-coil region (CC3) binding to the N-terminal coiled-coil region (CC1), preventing interaction with cytoplasmic dynein. This interaction inhibits the association with cytoplasmic dynein and its cargo-binding function. A structural rearrangement of the core packing in a homodimeric coiled-coil stimulates the release of CC1 from the CC3 region following cargo-binding. Additionally, the three residues (Glu772, Ile784, and Lys787), which are required for Rab6 binding, play a critical role in maintaining the autoinhibitory state through direct interaction with the N-terminal CC1 region.
Autoinhibitory domains (AIDs)
Target domain |
10-317 (CC1 region) |
Relief mechanism |
Partner binding |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q921C5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q921C5-F1 | Predicted | AlphaFoldDB |
40 variants for Q921C5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389280311 | 59 | L>Q | No | EVA | |
| rs247811360 | 98 | S>R | No | EVA | |
| rs3389256262 | 128 | L>M | No | EVA | |
| rs3389266518 | 216 | E>D | No | EVA | |
| rs3389210037 | 250 | E>K | No | EVA | |
| rs3389274091 | 277 | Q>H | No | EVA | |
| rs3389278954 | 289 | T>I | No | EVA | |
| rs3389256279 | 295 | N>I | No | EVA | |
| rs3389282051 | 304 | G>A | No | EVA | |
| rs3389292272 | 318 | K>N | No | EVA | |
| rs3389274098 | 349 | K>N | No | EVA | |
| rs3389282135 | 357 | M>R | No | EVA | |
| rs3389282112 | 368 | L>V | No | EVA | |
| rs3389284121 | 396 | L>P | No | EVA | |
| rs3550187592 | 408 | R>Q | No | EVA | |
| rs3389284160 | 409 | Q>H | No | EVA | |
| rs3389284093 | 418 | R>H | No | EVA | |
| rs3389284113 | 420 | S>N | No | EVA | |
| rs3389282503 | 424 | G>D | No | EVA | |
| rs3389266534 | 465 | R>C | No | EVA | |
| rs3389210068 | 469 | H>Q | No | EVA | |
| rs3389282455 | 473 | K>T | No | EVA | |
| rs3389274059 | 484 | T>I | No | EVA | |
| rs3389274059 | 484 | T>N | No | EVA | |
| rs3550331284 | 489 | L>M | No | EVA | |
| rs3389297484 | 509 | K>M | No | EVA | |
| rs3389278775 | 527 | D>E | No | EVA | |
| rs3389256322 | 564 | G>R | No | EVA | |
| rs3389210066 | 566 | A>G | No | EVA | |
| rs3389292238 | 574 | R>C | No | EVA | |
| rs223348890 | 590 | E>D | No | EVA | |
| rs3389297466 | 596 | G>D | No | EVA | |
| rs3389279013 | 601 | N>K | No | EVA | |
| rs3389289436 | 627 | I>N | No | EVA | |
| rs3389282476 | 643 | R>H | No | EVA | |
| rs3389278785 | 645 | T>S | No | EVA | |
| rs3389266560 | 678 | L>Q | No | EVA | |
| rs3389289441 | 733 | K>N | No | EVA | |
| rs3389279035 | 762 | R>W | No | EVA | |
| rs225275605 | 810 | A>T | No | EVA |
No associated diseases with Q921C5
5 regional properties for Q921C5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Helicase, C-terminal domain-like | 377 - 542 | IPR001650 |
| domain | DEAD/DEAH box helicase domain | 175 - 354 | IPR011545 |
| domain | Helicase superfamily 1/2, ATP-binding domain | 170 - 381 | IPR014001 |
| domain | RNA helicase, DEAD-box type, Q motif | 151 - 179 | IPR014014 |
| domain | Ded1/Dbp1, DEAD-box helicase domain | 152 - 372 | IPR044763 |
Functions
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| annulate lamellae | Stacks of endoplasmic reticulum (ER) membranes containing a high density of nuclear pores, thought to form from excess nuclear membrane components, that have been described in a number of different cells. Annulate lamellar membranes are continuous with and embedded within the ER. |
| centrosome | A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. |
| cytoplasmic vesicle | A vesicle found in the cytoplasm of a cell. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| nuclear envelope | The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). |
| nuclear pore | A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| cytoskeletal anchor activity | The binding activity of a protein that brings together a cytoskeletal protein (either a microtubule or actin filament, spindle pole body, or protein directly bound to them) and one or more other molecules, permitting them to function in a coordinated way. |
| dynactin binding | Binding to a dynactin complex; a large protein complex that activates dynein-based motor activity. |
| dynein complex binding | Binding to a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity. |
| dynein light intermediate chain binding | Binding to a light intermediate chain of the dynein complex. |
| small GTPase binding | Binding to a small monomeric GTPase. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| centrosome localization | Any process in which a centrosome is transported to, and/or maintained in, a specific location within the cell. |
| microtubule anchoring at microtubule organizing center | Any process in which a microtubule is maintained in a specific location in a cell by attachment to a microtubule organizing center. |
| microtubule-based movement | A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules. |
| minus-end-directed organelle transport along microtubule | The directed movement of an organelle towards the minus end of a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination. |
| mRNA transport | The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| protein localization to Golgi apparatus | A process in which a protein is transported to, or maintained in, a location within the Golgi apparatus. |
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| regulation of microtubule cytoskeleton organization | Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. |
| retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P16568 | BicD | Protein bicaudal D | Drosophila melanogaster (Fruit fly) | EV |
| Q96G01 | BICD1 | Protein bicaudal D homolog 1 | Homo sapiens (Human) | SS |
| Q8TD16 | BICD2 | Protein bicaudal D homolog 2 | Homo sapiens (Human) | SS |
| Q8BR07 | Bicd1 | Protein bicaudal D homolog 1 | Mus musculus (Mouse) | EV |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSAPSEEEEY | ARLVMEAQPE | WLRAEVKRLS | HELAETTREK | IQAAEYGLAV | LEEKHQLKLQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FEELEVDYEA | IRSEMEQLKE | AFGQAHTNHK | KVAADGESRE | ESLIQESASK | EQYYVRKVLE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LQTELKQLRN | VLTNTQSENE | RLTSVAQELK | EINQNVEIQR | GRLRDDIKEY | KFREARLLQD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YSELEEENIS | LQKQVSVLRQ | NQVEFEGLKH | EIKRLEEETE | YLNSQLEDAI | RLKEISERQL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EEALETLKTE | REQKNNLRKE | LSHYMSINDS | FYTSHLQVSL | DGLKFSDDTV | TAEPNNDAEA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LVNGFEHSGL | VKSSLDNKTS | TPRKDGLAPP | SPSLVSDLLS | ELHISEIQKL | KQQLVQMERE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KVGLLATLQD | TQKQLEQARG | TLSEQHEKVN | RLTENLSALR | RLQAGKERQT | SLDNEKDRDS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| HEDGDYYEVD | INGPEILACK | YHVAVAEAGE | LREQLKALRS | THEAREAQHA | EEKGRYEAEG |
| 490 | 500 | 510 | 520 | 530 | 540 |
| QALTEKISLL | EKASHQDREL | LAHLEKELKK | VSDVAGETQG | SLNVAQDELV | TFSEELANLY |
| 550 | 560 | 570 | 580 | 590 | 600 |
| HHVCMCNNET | PNRVMLDYYR | EGQGKAGRTS | PEGRGRRSPV | LLPKGLLATE | VGRADGGTGD |
| 610 | 620 | 630 | 640 | 650 | 660 |
| NSPSPSSSLP | SPLSDPRREP | MNIYNLIAII | RDQIKHLQAA | VDRTTELSRQ | RIASQELGPA |
| 670 | 680 | 690 | 700 | 710 | 720 |
| VDKDKEALME | EILKLKSLLS | TKREQITTLR | TVLKANKQTA | EVALANLKSK | YENEKAMVTE |
| 730 | 740 | 750 | 760 | 770 | 780 |
| TMMKLRNELK | ALKEDAATFS | SLRAMFATRC | DEYITQLDEM | QRQLAAAEDE | KKTLNSLLRM |
| 790 | 800 | 810 | |||
| AIQQKLALTQ | RLELLELDHE | QTRRGRSKAA | SKAKPASPSL |