Q92126

PR
Gene name
atp4a
Protein name
Potassium-transporting ATPase alpha chain 1
Names
Gastric H(+)/K(+) ATPase subunit alpha, Proton pump
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
EC number
7.2.2.19: Linked to the hydrolysis of a nucleoside triphosphate
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-82 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q92126

Entry ID Method Resolution Chain Position Source
AF-Q92126-F1 Predicted AlphaFoldDB

No variants for Q92126

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q92126

No associated diseases with Q92126

4 regional properties for Q92126

Type Name Position InterPro Accession
domain Cation-transporting P-type ATPase, N-terminal 49 - 123 IPR004014
domain Cation-transporting P-type ATPase, C-terminal 806 - 1015 IPR006068
ptm P-type ATPase, phosphorylation site 383 - 389 IPR018303
domain P-type ATPase, haloacid dehalogenase domain 362 - 774 IPR044492

Functions

Description
EC Number 7.2.2.19 Linked to the hydrolysis of a nucleoside triphosphate
Subcellular Localization
  • Membrane; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
metal ion binding Binding to a metal ion.
P-type potassium:proton transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) + K+(out) = ADP + phosphate + H+(out) + K+(in).

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGKKEQYDMY SVEMEREGDG AMDVKVMKKN KASKKKEKLE SMKKEMDIND HEITVEELEQ
70 80 90 100 110 120
KYTTSVSKGL KSAFAAEVIL RDGPNELKPP KGTPEYIKFA RQLAGGLQCL MWVAAVICLI
130 140 150 160 170 180
AFGIEESQGD LTSADNLYLA ITLIAVVVVT GCFGYYQEFK STNIIASFKN LVPQQATVVR
190 200 210 220 230 240
DGDKFQINAN QLVVGDLVEI KGGDRVPADI RIITSQGCKV DNSSLTGESE PQTRSPEYTH
250 260 270 280 290 300
ESPLETRNIA FFSTMCLEGT ATGIIINTGD RTIIGRIATL ASGVGNEKTP IAIEIEHFVD
310 320 330 340 350 360
IIAGLAIFFG ATFFVVAMVI GYTFLRAMVF FMAIVVAYVP EGLLATVTVC LSLTAKRLAR
370 380 390 400 410 420
KNCVVKNLEA VETLGSTSVI CSDKTGTLTQ NRMTVSHLWF DNHIHSADTT EDQSGQSFDQ
430 440 450 460 470 480
TSDTWRALSK VVSLCNRAFF KSGQDGIPVP KRIVIGDASE TALVKFSEIT VGNVMEYRER
490 500 510 520 530 540
FKKVTEVPFN STNKFQLSIH ELQDPLDLRY LMVMKGAPER ILERCSTIMI KGQELPLDEQ
550 560 570 580 590 600
WKEAFQTAYM DLGGLGERVL GFCHLYLNEK EYSRGFNFDT EEMNFPTSGL CFAGLISMID
610 620 630 640 650 660
PPRATVPDAV MKCRTAGIRV IMVTGDHPIT AKAIAASVGI ISEGSETVED IAARLRIPVE
670 680 690 700 710 720
QVNKRDARAC VINGGQLKEM SSEELVEALK LHPEMVFART SPQQKLIIVE SCQKLGAIVA
730 740 750 760 770 780
VTGDGVNDSP ALKKADIGVA MGIAGSDAAK NAADMILLDD NFASIVTGVE QGRLIFDNLK
790 800 810 820 830 840
KSIAYTLTKN IPELAPYLIY ITASVPLPLG CITILFIELC TDIFPSVSLA YERAESDIMH
850 860 870 880 890 900
LKPRNPRRDR LVNEALAVYS YFQIGIIQSF AGFVDYFTVM AQEGWFPAYV LGLRSHWENQ
910 920 930 940 950 960
HLQDLQDSYG QEWTFSQRLY QQYTCYTVFF ISYEICQISD VLIRKTRRLS VFQQGFFRNK
970 980 990 1000 1010 1020
VLVIAIVFQL CLGNFLCYCP GMPNVFNFMP IRFQWWLVPL PFGILIFVYD EIRKLGVRRH
1030
PGSWFDKEMY Y