Q92104

PR
Gene name
CYP11B
Protein name
Cytochrome P450 11B, mitochondrial
Names
CYPXIB, Cytochrome P450C11, P-450(11 beta,aldo), Steroid 11-beta-hydroxylase
Species
Lithobates catesbeianus (American bullfrog) (Rana catesbeiana)
KEGG Pathway
EC number
1.14.15.4: With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

9-79 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q92104

Entry ID Method Resolution Chain Position Source
AF-Q92104-F1 Predicted AlphaFoldDB

No variants for Q92104

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q92104

No associated diseases with Q92104

1 regional properties for Q92104

Type Name Position InterPro Accession
conserved_site Cytochrome P450, conserved site 458 - 467 IPR017972

Functions

Description
EC Number 1.14.15.4 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
Subcellular Localization
  • Mitochondrion membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
mitochondrial membrane Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.

3 GO annotations of molecular function

Name Definition
heme binding Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
iron ion binding Binding to an iron (Fe) ion.
steroid 11-beta-monooxygenase activity Catalysis of the reaction: a steroid + reduced adrenal ferredoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O.

1 GO annotations of biological process

Name Definition
steroid biosynthetic process The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLEKTAARQI GSCLMRCRTL DTTSPLWTGF SRLSTAPLIH EAREDGSLAS QTLPYEAIPT
70 80 90 100 110 120
TGRSAWFNLF QFWRKNSFQH MHLAMEENFQ NLGPIYREKL GTHNSVNIML PQDVARLFQS
130 140 150 160 170 180
EGIFPRRMTM EAWSKHRELR NHKQGVFLLN GEAWRSDRII LNKEVLSLAG VKKFLPFLDE
190 200 210 220 230 240
AAADFVTFMK KRMSKNTRGS LTVDLYADLF RFTLEASSYV LYGQRLGLLE EHPNADTLRF
250 260 270 280 290 300
ISAVETVLKT TLPLLYYPHQ ILQLFQTRLW NEHMHAWDVI FEQADRCIQN IYQEYCLGQE
310 320 330 340 350 360
RGYSGIMAEL LLQAELPLDS IKANITELMA GGVDTTAMPL LFTLFELARN PSVQRELREE
370 380 390 400 410 420
IRKAEAQNPN DLNQLLNSLP LLKGAIKETL RLYPVGITVQ RHLIKDIVLH NYHIPAGTLV
430 440 450 460 470 480
QVGLYPMGRS PLLFQDALRY DPARWLKRED TNFKALAFGF GSRQCIGRRI AETEITLFLM
490 500 510
HMLKNFQIDT VSKDDIKTVF GFILMPEKPP LLTFRPI