Q91YR7
PR
Gene name |
Prpf6 |
Protein name |
Pre-mRNA-processing factor 6 |
Names |
PRP6 homolog, U5 snRNP-associated 102 kDa protein, U5-102 kDa protein |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:68879 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for Q91YR7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 6QX9 | EM | 328 A | 5J | 18-655 | PDB |
| AF-Q91YR7-F1 | Predicted | AlphaFoldDB |
41 variants for Q91YR7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3392454792 | 16 | G>D | No | EVA | |
| rs3388621742 | 30 | T>S | No | EVA | |
| rs3388606267 | 49 | A>V | No | EVA | |
| rs3388618921 | 55 | T>I | No | EVA | |
| rs3388613447 | 75 | D>E | No | EVA | |
| rs3388614221 | 89 | F>L | No | EVA | |
| rs3388616800 | 94 | Y>F | No | EVA | |
| rs3388613462 | 96 | K>Q | No | EVA | |
| rs3388614277 | 135 | R>P | No | EVA | |
| rs3388610849 | 190 | H>R | No | EVA | |
| rs3388619026 | 193 | T>I | No | EVA | |
| rs3392729234 | 225 | G>V | No | EVA | |
| rs3392454775 | 226 | M>I | No | EVA | |
| rs3392693477 | 227 | T>P | No | EVA | |
| rs3388624422 | 232 | T>A | No | EVA | |
| rs3388618611 | 270 | P>L | No | EVA | |
| rs3388613432 | 277 | L>Q | No | EVA | |
| rs3388610858 | 343 | E>D | No | EVA | |
| rs3392693515 | 349 | A>T | No | EVA | |
| rs3388621346 | 353 | Q>H | No | EVA | |
| rs3388618565 | 355 | G>R | No | EVA | |
| rs3388616221 | 363 | A>S | No | EVA | |
| rs3388621386 | 385 | D>N | No | EVA | |
| rs3392574380 | 425 | R>P | No | EVA | |
| rs3388621793 | 513 | C>G | No | EVA | |
| rs3388618930 | 554 | N>K | No | EVA | |
| rs3388621337 | 562 | I>L | No | EVA | |
| rs3388618582 | 565 | Y>H | No | EVA | |
| rs3388616727 | 566 | A>T | No | EVA | |
| rs3388625076 | 571 | P>T | No | EVA | |
| rs3388618974 | 612 | L>R | No | EVA | |
| rs3388617123 | 615 | A>V | No | EVA | |
| rs3388624436 | 698 | C>S | No | EVA | |
| rs3388621368 | 738 | K>N | No | EVA | |
| rs3388621813 | 740 | P>H | No | EVA | |
| rs3388624424 | 741 | H>R | No | EVA | |
| rs3388606272 | 758 | Q>E | No | EVA | |
| rs3388616802 | 764 | A>G | No | EVA | |
| rs3388624417 | 766 | L>F | No | EVA | |
| rs3388621381 | 767 | E>G | No | EVA | |
| rs3388621422 | 870 | I>N | No | EVA |
No associated diseases with Q91YR7
18 regional properties for Q91YR7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | HAT (Half-A-TPR) repeat | 289 - 321 | IPR003107-1 |
| repeat | HAT (Half-A-TPR) repeat | 323 - 355 | IPR003107-2 |
| repeat | HAT (Half-A-TPR) repeat | 384 - 416 | IPR003107-3 |
| repeat | HAT (Half-A-TPR) repeat | 417 - 446 | IPR003107-4 |
| repeat | HAT (Half-A-TPR) repeat | 447 - 476 | IPR003107-5 |
| repeat | HAT (Half-A-TPR) repeat | 554 - 586 | IPR003107-6 |
| repeat | HAT (Half-A-TPR) repeat | 588 - 620 | IPR003107-7 |
| repeat | HAT (Half-A-TPR) repeat | 622 - 654 | IPR003107-8 |
| repeat | HAT (Half-A-TPR) repeat | 656 - 687 | IPR003107-9 |
| repeat | HAT (Half-A-TPR) repeat | 689 - 721 | IPR003107-10 |
| repeat | HAT (Half-A-TPR) repeat | 723 - 755 | IPR003107-11 |
| repeat | HAT (Half-A-TPR) repeat | 757 - 789 | IPR003107-12 |
| repeat | HAT (Half-A-TPR) repeat | 791 - 823 | IPR003107-13 |
| domain | PRP1 splicing factor, N-terminal | 13 - 169 | IPR010491 |
| repeat | Tetratricopeptide repeat | 675 - 708 | IPR019734-1 |
| repeat | Tetratricopeptide repeat | 709 - 742 | IPR019734-2 |
| repeat | Tetratricopeptide repeat | 743 - 776 | IPR019734-3 |
| repeat | Tetratricopeptide repeat | 841 - 874 | IPR019734-4 |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| catalytic step 2 spliceosome | A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs. |
| nuclear speck | A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| U2-type precatalytic spliceosome | A spliceosomal complex that is formed by the recruitment of the preassembled U4/U6.U5 tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the U1, U2 and U4/U6.U5 snRNPs. |
| U4/U6 x U5 tri-snRNP complex | A ribonucleoprotein complex that is formed by the association of the U4/U6 and U5 snRNPs. |
| U5 snRNP | A ribonucleoprotein complex that contains small nuclear RNA U5, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U5 snRNP, most of which remain associated with the U5 snRNA both while the U5 snRNP is free or assembled into a series of spliceosomal complexes. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| identical protein binding | Binding to an identical protein or proteins. |
| nuclear androgen receptor binding | Binding to a nuclear androgen receptor. |
| ribonucleoprotein complex binding | Binding to a complex of RNA and protein. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| transcription coactivator activity | A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| mRNA splicing, via spliceosome | The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| RNA localization | A process in which RNA is transported to, or maintained in, a specific location. |
| spliceosomal tri-snRNP complex assembly | The formation of a tri-snRNP complex containing U4 and U6 (or U4atac and U6atac) snRNAs and U5 snRNAs and associated proteins. This includes reannealing of U4 and U6 (or U4atac and U6atac) snRNAs released from previous rounds of splicing to reform the U4/U6 snRNP (or U4atac/U6atac snRNP) as well as the subsequent association of the U5 snRNP with the U4/U6 snRNP (or U4atac/U6atac snRNP) to form a tri-snRNP that is ready to reassemble into another spliceosome complex. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q2KJJ0 | PRPF6 | Pre-mRNA-processing factor 6 | Bos taurus (Bovine) | PR |
| O94906 | PRPF6 | Pre-mRNA-processing factor 6 | Homo sapiens (Human) | PR |
| Q9DCD2 | Xab2 | Pre-mRNA-splicing factor SYF1 | Mus musculus (Mouse) | PR |
| P63154 | Crnkl1 | Crooked neck-like protein 1 | Mus musculus (Mouse) | PR |
| A1A5S1 | Prpf6 | Pre-mRNA-processing factor 6 | Rattus norvegicus (Rat) | PR |
| Q9SCU8 | BGAL14 | Beta-galactosidase 14 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNKKKKPFLG | MPAPLGYVPG | LGRGATGFTT | RSDIGPARDA | NDPVDDRHAP | PGKRTVGDQM |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KKNQAADDDD | EDLNDTNYDE | FNGYAGSLFS | SGPYEKDDEE | ADAIYAALDK | RMDERRKERR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EQREKEEIEK | YRMERPKIQQ | QFSDLKRKLA | EVTEEEWLSI | PEVGDARNKR | QRNPRYEKLT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PVPDSFFAKH | LQTGENHTSV | DPRQTQFGGL | NTPYPGGLNT | PYPGGMTPGL | MTPGTGELDM |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RKIGQARNTL | MDMRLSQVSD | SVSGQTVVDP | KGYLTDLNSM | IPTHGGDIND | IKKARLLLKS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VRETNPHHPP | AWIASARLEE | VTGKLQVARN | LIMKGTEMCP | KSEDVWLEAA | RLQPGDTAKA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VVAQAVRHLP | QSVRIYIRAA | ELETDIRAKK | RVLRKALEHV | PNSVRLWKAA | VELEEPEDAR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| IMLSRAVECC | PTSVELWLAL | ARLETYENAR | KVLNKARENI | PTDRHIWITA | AKLEEANGNT |
| 490 | 500 | 510 | 520 | 530 | 540 |
| QMVEKIIDRA | ITSLRANGVE | INREQWIQDA | EECDRAGSVA | TCQAVMRAVI | GIGIEEEDRK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| HTWMEDADSC | VAHNALECAR | AIYAYALQVF | PSKKSVWLRA | AYFEKNHGTR | ESLEALLQRA |
| 610 | 620 | 630 | 640 | 650 | 660 |
| VAHCPKAEVL | WLMGAKSKWL | AGDVPAARSI | LALAFQANPN | SEEIWLAAVK | LESENNEYER |
| 670 | 680 | 690 | 700 | 710 | 720 |
| ARRLLAKARS | SAPTARVFMK | SVKLEWVLGN | ISAAQELCEE | ALRHYEDFPK | LWMMKGQIEE |
| 730 | 740 | 750 | 760 | 770 | 780 |
| QGELMEKARE | AYNQGLKKCP | HSTPLWLLLS | RLEEKIGQLT | RARAILEKSR | LKNPKNPGLW |
| 790 | 800 | 810 | 820 | 830 | 840 |
| LESVRLEYRA | GLKNIANTLM | AKALQECPNS | GILWSEAVFL | EARPQRKTKS | VDALKKCEHD |
| 850 | 860 | 870 | 880 | 890 | 900 |
| PHVLLAVAKL | FWSERKITKA | REWFHRTVKI | DSDLGDAWAF | FYKFELQHGT | EEQQEEVRKR |
| 910 | 920 | 930 | 940 | ||
| CENAEPRHGE | LWCAVSKDIT | NWQRKIGEIL | VLVAARIKNT | F |