AiPD: Autoinhibited Protein Database

Gene name	Mtif2
Protein name	Translation initiation factor IF-2, mitochondrial
Names	IF-2(Mt), IF-2Mt, IF2(mt)
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:76784
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

29-109 (Predicted disordered autoinhibitory region) PR

29-109 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
2CRV	NMR	-	A	621-727	PDB
AF-Q91YJ5-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs26871496	3	Q>R	No	EVA
rs3401787209	4	K>*	No	EVA
rs216951949	15	H>P	No	EVA
rs238938223	21	V>L	No	EVA
rs220545585	29	L>P	No	EVA
rs3401787228	31	A>V	No	EVA
rs220485886	44	W>C	No	EVA
rs26871494	46	D>G	No	EVA
rs264105791	50	A>T	No	EVA
rs225380199	54	Q>H	No	EVA
rs239413597	56	D>H	No	EVA
rs256134311	57	M>V	No	EVA
rs3389145384	69	L>F	No	EVA
rs3389140618	76	R>G	No	EVA
rs3402104478	409	E>*	No	EVA
rs3389155875	466	K>R	No	EVA
rs221353258	468	R>K	No	EVA
rs3402272356	493	K>E	No	EVA
rs228247887	543	E>K	No	EVA
rs3402272328	555	D>N	No	EVA
rs3401388352	557	S>I	No	EVA
rs3402151529	558	E>*	No	EVA
rs3402065395	558	E>D	No	EVA
rs3402151576	558	E>V	No	EVA
rs3401652726	559	N>T	No	EVA
rs3389147842	560	D>G	No	EVA
rs241743707	591	V>I	No	EVA
rs3389142770	628	I>K	No	EVA
rs3389085206	638	K>T	No	EVA
rs3389157895	639	K>E	No	EVA
rs239422015	656	H>Q	No	EVA
rs3389122370	693	G>D	No	EVA
rs29436813	701	V>F	No	EVA

Type	Name	Position	InterPro Accession
domain	Translational (tr)-type GTP-binding domain	178 - 346	IPR000795
domain	Small GTP-binding protein domain	181 - 304	IPR005225
domain	Translation initiation factor IF- 2, domain 3	506 - 606	IPR023115
domain	Translation initiation factor IF-2, domain II	354 - 448	IPR044145

		Description
EC Number
Subcellular Localization	Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.

Name	Definition
GTP binding	Binding to GTP, guanosine triphosphate.
GTPase activity	Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
ribosomal small subunit binding	Binding to a small ribosomal subunit.
translation factor activity, RNA binding	Functions during translation by binding to RNA during polypeptide synthesis at the ribosome.
translation initiation factor activity	Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.

Name	Definition
mitochondrial translational initiation	The process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA.
ribosome disassembly	The disaggregation of a ribosome into its constituent components; includes the dissociation of ribosomal subunits.
translational initiation	The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P0A705	infB	Translation initiation factor IF-2	Escherichia coli (strain K12)	PR
P46199	MTIF2	Translation initiation factor IF-2, mitochondrial	Homo sapiens (Human)	PR