Q91XU0
Gene name |
Wrnip1 |
Protein name |
ATPase WRNIP1 |
Names |
Werner helicase-interacting protein 1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:78903 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q91XU0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q91XU0-F1 | Predicted | AlphaFoldDB |
16 variants for Q91XU0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs235663406 | 50 | P>S | No | EVA | |
| rs13467435 | 73 | R>L | No | EVA | |
| rs3389243593 | 307 | A>P | No | EVA | |
| rs3404034232 | 349 | G>V | No | EVA | |
| rs3403944049 | 350 | A>P | No | EVA | |
| rs246140879 | 361 | A>T | No | EVA | |
| rs3403326959 | 392 | G>S | No | EVA | |
| rs3403326932 | 394 | H>* | No | EVA | |
| rs48964459 | 455 | V>M | No | EVA | |
| rs3389283617 | 487 | Y>* | No | EVA | |
| rs3404147058 | 501 | L>P | No | EVA | |
| rs3389269219 | 506 | R>C | No | EVA | |
| rs3389243628 | 612 | H>Q | No | EVA | |
| rs3389276077 | 620 | L>V | No | EVA | |
| rs3389250901 | 654 | F>S | No | EVA | |
| rs1131872301 | 661 | C>L | No | EVA |
No associated diseases with Q91XU0
6 regional properties for Q91XU0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | AAA+ ATPase domain | 255 - 375 | IPR003593 |
| domain | ATPase, AAA-type, core | 259 - 371 | IPR003959 |
| domain | Rad18, zinc finger UBZ4-type | 17 - 44 | IPR006642 |
| domain | MgsA AAA+ ATPase C-terminal | 507 - 657 | IPR021886 |
| domain | AAA C-terminal domain | 416 - 506 | IPR032423 |
| domain | WRNIP1, ubiquitin-binding domain | 16 - 36 | IPR040539 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromosome, telomeric region | The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres). |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| perinuclear region of cytoplasm | Cytoplasm situated near, or occurring around, the nucleus. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| enzyme activator activity | Binds to and increases the activity of an enzyme. |
| identical protein binding | Binding to an identical protein or proteins. |
| metal ion binding | Binding to a metal ion. |
| single-stranded DNA helicase activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of a DNA helix. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA synthesis involved in DNA repair | Synthesis of DNA that proceeds from the broken 3' single-strand DNA end and uses the homologous intact duplex as the template. |
| DNA-templated DNA replication | A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands. |
| innate immune response | Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. |
| regulation of DNA repair | Any process that modulates the frequency, rate or extent of DNA repair. |
| regulation of DNA-templated DNA replication initiation | Any process that modulates the frequency, rate or extent of initiation of DNA-dependent DNA replication; the process in which DNA becomes competent to replicate. In eukaryotes, replication competence is established in early G1 and lost during the ensuing S phase. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q96S55 | WRNIP1 | ATPase WRNIP1 | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEVSGPEDDP | FLSQLHQVQC | PVCQQMMPAA | HINSHLDRCL | LLHPAGHAEP | AAGSHRAGER |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AKGPSPPGAK | RRRLSESSAL | KQPATPTAAE | SSEGEGEEGD | DGGETESRES | YDAPPTPSGA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RLIPDFPVAR | SSSPARKGMG | KRPAAAAAAG | SASPRSWDEA | EAQEEEEAGV | DGDGDADVDG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EDDPGHWDAD | AADASFGVSA | GRAHPRALAA | EEIRQMLEGK | PLADKMRPDT | LQDYIGQSRA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VGQETLLRSL | LEANEIPSLI | LWGPPGCGKT | TLAHIIANNS | KKHSIRFVTL | SATNAKTNDV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RDVIKQAQNE | KSFFKRKTIL | FIDEIHRFNK | SQQDTFLPHV | ECGTITLIGA | TTENPSFQVN |
| 370 | 380 | 390 | 400 | 410 | 420 |
| AALLSRCRVI | VLEKLPVEAM | VTILMRAINS | LGIHVLDSSR | PTDPLSHSSN | CSSEPSVFIE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DKAVDTLAYL | SDGDARTGLN | GLQLAVLARL | SSRKVFCKKS | GQTYSPSRVL | ITENDVKEGL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| QRSHILYDRA | GEEHYNCISA | LHKAMRGSDQ | NASLYWLARM | LEGGEDPLYV | ARRLVRFASE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| DIGLADPSAL | AQAVAAYQGC | HFIGMPECEV | LLAQCVVYFA | RAPKSIEVYS | AYNNVKACLR |
| 610 | 620 | 630 | 640 | 650 | |
| SHQGPLPPVP | LHLRNAPTRL | MKDLGYGKGY | KYNPMYSEPV | DQDYLPEELR | GVDFFKQRRC |