Q91X78

PR
Gene name
Erlin1
Protein name
Erlin-1
Names
Endoplasmic reticulum lipid raft-associated protein 1, Protein KE04 homolog, Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1, SPFH domain-containing protein 1
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:226144
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

293-346 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q91X78

Entry ID Method Resolution Chain Position Source
AF-Q91X78-F1 Predicted AlphaFoldDB

11 variants for Q91X78

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389541351 77 P>S No EVA
rs3389540798 155 Q>R No EVA
rs3389508631 164 G>D No EVA
rs3389550794 204 V>SDG* No EVA
rs3389520757 214 K>N No EVA
rs3389556674 241 E>* No EVA
rs3389556641 276 H>R No EVA
rs3389541346 305 S>T No EVA
rs225783749 333 R>L No EVA
rs3389534333 343 N>T No EVA
rs3389541380 346 N>Y No EVA

No associated diseases with Q91X78

1 regional properties for Q91X78

Type Name Position InterPro Accession
domain Band 7 domain 23 - 209 IPR001107

Functions

Description
EC Number
Subcellular Localization
  • Endoplasmic reticulum membrane ; Single-pass type II membrane protein
  • Associated with lipid raft-like domains of the endoplasmic reticulum membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.

2 GO annotations of molecular function

Name Definition
cholesterol binding Binding to cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
ubiquitin protein ligase binding Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins.

6 GO annotations of biological process

Name Definition
cholesterol metabolic process The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues.
negative regulation of cholesterol biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol.
negative regulation of fatty acid biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids.
regulation of cholesterol biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol.
SREBP signaling pathway The series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of decreased levels of one or more sterols (and in some yeast, changes in oxygen levels) and which proceeds through activation of a sterol response element binding transcription factor (SREBP) to result in up-regulation of target gene transcription.
ubiquitin-dependent ERAD pathway The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNMTQARLLV AAVVGLVAIL LYASIHKIEE GHLAVYYRGG ALLTSPSGPG YHIMLPFITT
70 80 90 100 110 120
FRSVQTTLQT DEVKNVPCGT SGGVMIYIDR IEVVNMLAPY AVFDIVRNYT ADYDKTLIFN
130 140 150 160 170 180
KIHHELNQFC SAHTLQEVYI ELFDQIDENL KQALQKDLNT MAPGLTIQAV RVTKPKIPEA
190 200 210 220 230 240
IRRNFELMEA EKTKLLIAAQ KQKVVEKEAE TERKRAVIEA EKIAQVAKIR FQQKVMEKET
250 260 270 280 290 300
EKRISEIEDA AFLAREKAKA DAEYYAAHKY ATSNKHKLTP EYLELKKYQA IASNSKIYFG
310 320 330 340
SNIPSMFVDS SCALKYSDGR TGREDSLPPE EAREPSGESP IQNKENAG