Q91WB4
Gene name |
Plekhf2 |
Protein name |
Pleckstrin homology domain-containing family F member 2 |
Names |
PH domain-containing family F member 2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:71801 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q91WB4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q91WB4-F1 | Predicted | AlphaFoldDB |
12 variants for Q91WB4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs27731475 | 20 | S>N | No | EVA | |
| rs3388652725 | 21 | C>S | No | EVA | |
| rs3388672871 | 33 | G>V | No | EVA | |
| rs3388667303 | 95 | E>K | No | EVA | |
| rs3388673173 | 104 | T>K | No | EVA | |
| rs3388673797 | 111 | V>I | No | EVA | |
| rs3388677220 | 137 | S>G | No | EVA | |
| rs27731477 | 143 | N>H | No | EVA | |
| rs1134504303 | 164 | A>V | No | EVA | |
| rs3388673748 | 179 | G>D | No | EVA | |
| rs3388670250 | 207 | C>S | No | EVA | |
| rs3388666361 | 245 | D>Y | No | EVA |
No associated diseases with Q91WB4
Functions
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| early endosome | A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways. |
| early endosome membrane | The lipid bilayer surrounding an early endosome. |
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| transport vesicle | Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| metal ion binding | Binding to a metal ion. |
| phosphatidylinositol binding | Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| endosome organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of endosomes. |
| endosome to lysosome transport | The directed movement of substances from endosomes to lysosomes. |
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9H8W4 | PLEKHF2 | Pleckstrin homology domain-containing family F member 2 | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVDRLANSEA | NTRRISIVES | CFGAAGQPLT | IPGRVLIGEG | VLTKLCRKKP | KARQFFLFND |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ILVYGNIVIQ | KKKYNKQHII | PLENVTIDSI | KDEGELRNGW | LIKTPTKSFA | VYAATATEKS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EWMNHINKCV | TDLLSKSGKT | PSNEHAAVWV | PDSEATVCMR | CQKAKFTPVN | RRHHCRKCGF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VVCGPCSEKR | FLLPSQSSKP | VRICDFCYDL | LSTGDMAACQ | PTRSDSYSQS | LKSPLNDASD |
| DDDDDDSSD |