Q91VC4

PR
Gene name
Plvap (Pv1)
Protein name
Plasmalemma vesicle-associated protein
Names
MECA-32 antigen, Plasmalemma vesicle protein 1, PV-1
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:84094
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-117 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for Q91VC4

Entry ID Method Resolution Chain Position Source
8FBY X-ray 240 A A/B/C/D 141-229 PDB
8FCF X-ray 195 A C/D 141-229 PDB
AF-Q91VC4-F1 Predicted AlphaFoldDB

No variants for Q91VC4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q91VC4

No associated diseases with Q91VC4

No regional properties for Q91VC4

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q91VC4

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Single-pass type II membrane protein
  • Membrane, caveola ; Single-pass type II membrane protein
  • Cytoplasm, perinuclear region
  • Membrane-associated protein of caveolae
  • Found in fenestral and stomatal diaphragms in fenestrated endothelia and transendothelial channels
  • Also colocalized with CAV1 in perinuclear region
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
caveola A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm.
cell surface The external part of the cell wall and/or plasma membrane.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.

1 GO annotations of molecular function

Name Definition
identical protein binding Binding to an identical protein or proteins.

5 GO annotations of biological process

Name Definition
developmental process A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.
MAPK cascade An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
positive regulation of cellular extravasation Any process that activates or increases the frequency, rate, or extent of cellular extravasation.
regulation of vascular permeability Any process that modulates the extent to which blood vessels can be pervaded by fluid.
tumor necrosis factor-mediated signaling pathway The series of molecular signals initiated by tumor necrosis factor binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9BX97 PLVAP Plasmalemma vesicle-associated protein Homo sapiens (Human) PR
Q9WV78 Plvap Plasmalemma vesicle-associated protein Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MGLSMDRSPY ARTGDQQRGC WYYLRYFFLF VSLIQFLIIL GLVLFMIYGN VHATTESSLR
70 80 90 100 110 120
ATEIRADSLY SQVVGLSASQ ANLSKQLNIS LLVKETVMQQ LLTTRREMER INASFRQCQG
130 140 150 160 170 180
DLITYINYNR FIAAIILSEK QCQEQLKEVN KTCEALLFKL GEKVKTLEME VAKEKAVCSK
190 200 210 220 230 240
DKESLLAGKR QTEEQLEACG KARERQQQEQ QVTEENLRKV QSLCIPLDQE KFQADVLSAW
250 260 270 280 290 300
RDSLIYRTLE TLPYHYQLMP EYASLRRTCE SLPGIMTTKI EELARGLRAG IERVTRENAE
310 320 330 340 350 360
LRRQKLELER AAQAAQEARA RAGTEAQARE TQLRAECARQ TQLALEEKAA LRAQRDNLER
370 380 390 400 410 420
ELEARKRELE QLRTEVDVRI SALDTCVKAK SLPAVPPRVS GPPPNPPPID PASLEEFKKR
430
ILESQRLPVV NPAAQPSG