Q91E95

PR
Gene name
Protein name
RNA-directed RNA polymerase
Names
Protein VP1
Species
Rotavirus C (isolate RVC/Human/United Kingdom/Bristol/1989) (RV-C)
KEGG Pathway
vg:3773137
EC number
2.7.7.48: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

85-154 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

0 structures for Q91E95

Entry ID Method Resolution Chain Position Source

No variants for Q91E95

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q91E95

No associated diseases with Q91E95

2 regional properties for Q91E95

Type Name Position InterPro Accession
domain RNA-directed RNA polymerase, reovirus 506 - 678 IPR007097
domain Rotavirus VP1 RNA-directed RNA polymerase, C-terminal 778 - 1090 IPR022071

Functions

Description
EC Number 2.7.7.48 Nucleotidyltransferases
Subcellular Localization
  • Virion
  • Attached inside the inner capsid as a minor component
  • Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
virion component Any constituent part of a virion, a complete fully infectious extracellular virus particle.

3 GO annotations of molecular function

Name Definition
nucleotide binding Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template, i.e. the catalysis of RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time.

2 GO annotations of biological process

Name Definition
DNA-templated transcription The synthesis of an RNA transcript from a DNA template.
viral genome replication Any process involved directly in viral genome replication, including viral nucleotide metabolism.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAQSIVVDGD YDALASRYLK FVYDFENVTY QNNYFATDKF KKDIEQYLKS IHDGEKITQS
70 80 90 100 110 120
KIDEKEKILL DRVPAEERCL ISKLVFAYGK HGNVENKLVK YGVKDALSHA PQKDAKPYEN
130 140 150 160 170 180
NIITSEIFKE KSEYTDIYMD PSINTSCQSN CQAMMFTISE MKLNNIKNAA RLEKLFTIIA
190 200 210 220 230 240
ATINKYGMPR HNTRYRYEWE TMKNKPYHLA AWINSSIEMI ACVVDHHTYM IARELIVKSF
250 260 270 280 290 300
TNRTSLAKLV SSPMTVLTAM LPIRGTFITT ENLELEYSNK SINYLISKEM AEDFMQAIKQ
310 320 330 340 350 360
LRDEGLEYIP DYYEKWFKSP DPLTFPNIAL IYSFSFHVGY RKQALSDAVY DQITVTYSDN
370 380 390 400 410 420
VNMEMYKEYS ERIENEIFTI LKDKIIHEDK RLEEYELSAL LSMSSASNGI LREINFGGQK
430 440 450 460 470 480
VRSTKKNMHV IDDIYHKKYT TDIPPVDARN PIPLGRRDVP GRRTRAIFIL PYQYFIAQHS
490 500 510 520 530 540
FAEIMLNYAK REREYSEFYS QANQVLSYGD VTRYLDSNSI LCFTDVSQWD ASQHNTKVLR
550 560 570 580 590 600
RSIIRAMKRL KQLTHNINIH KAINIYIQSQ ENLENSYVLI DKKAIQYGAT ASGEKQTKIM
610 620 630 640 650 660
NSIANKALIQ TVLGKLMTDY TFDVKMIRVD GDDNYAIVRF PIAITEKLLS EFTSKLRSYY
670 680 690 700 710 720
SEMNVKVKAL ASLTGCEIAK RYVAGGMLFF RAGVNILHHE KRNQDSAYDM AATLYANYIV
730 740 750 760 770 780
NALRGLTMSR TFILTKICQM TSIKITGTLR LFPMKSILAL NSAFKVFDEV DYVINYPISN
790 800 810 820 830 840
LFIQLQRKLS SIKAKSKIAD NIAKSPQFKS YVELLNKSLT TDENPIVSDG IRLTEKAKLN
850 860 870 880 890 900
SYAPIALEKR RDQFSIMVSF LQNPTTFKSE TVVTINDVLY FISGFIKIDS STVLPKEENN
910 920 930 940 950 960
TMPLLPAIIK RTLSYFGLRT HDYDIKGSSS TVSKIIKQYS VYTPGIEELY EIVNKSVDTI
970 980 990 1000 1010 1020
RGYFASFNVP KADVDTYIST QMYKHDRFKI LQAYIYNLLS VNYGMYQLVD LNSARFFDHV
1030 1040 1050 1060 1070 1080
IHTPMAKTPT AVFMIDLALR LKIINHCIEK GEIITVSVHA NKTDYLKLWR MLWNVKTMNS
PYSKNSMFDE