Q91829

PR
Gene name
rag1
Protein name
V(D)J recombination-activating protein 1
Names
RAG-1
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:100337558
EC number
2.3.2.27: Aminoacyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

4-120 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q91829

Entry ID Method Resolution Chain Position Source
AF-Q91829-F1 Predicted AlphaFoldDB

No variants for Q91829

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q91829

No associated diseases with Q91829

6 regional properties for Q91829

Type Name Position InterPro Accession
domain Zinc finger, RING-type 294 - 333 IPR001841
conserved_site Zinc finger, RING-type, conserved site 309 - 318 IPR017907
domain Zinc finger, C3HC4 RING-type 294 - 332 IPR018957
domain V(D)J recombination-activating protein 1, Zinc finger 355 - 384 IPR019485
domain RAG nonamer-binding domain 395 - 462 IPR023336
domain RAG1 importin-binding 7 - 292 IPR035714

Functions

Description
EC Number 2.3.2.27 Aminoacyltransferases
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

8 GO annotations of molecular function

Name Definition
endonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks.
histone binding Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription.
metal ion binding Binding to a metal ion.
protein homodimerization activity Binding to an identical protein to form a homodimer.
sequence-specific DNA binding Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
ubiquitin protein ligase activity Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
ubiquitin-protein transferase activity Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
zinc ion binding Binding to a zinc ion (Zn).

5 GO annotations of biological process

Name Definition
B cell differentiation The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity.
chromatin organization The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA.
histone monoubiquitination The modification of histones by addition of a single ubiquitin group.
T cell differentiation in thymus The process in which a precursor cell type acquires the specialized features of a T cell via a differentiation pathway dependent upon transit through the thymus.
V(D)J recombination The process in which immune receptor V, D, and J, or V and J gene segments, depending on the specific receptor, are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS).

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEVALPNVPT KMQHPFTKYS EWKFKLFRVK SLERRPSEEE TEGSEVSYNS SQETYPKSTV
70 80 90 100 110 120
VLEDLSLGSA PQSPTNFKPQ QSEKSNVVDN HETDLKRLEE EAHITVIQQL CRICGASFKM
130 140 150 160 170 180
DQQNRSYPVH GPVDSETHDI LRRREKKVTS WPELISKVFK TDVRADVDTI HPTQFCHNCW
190 200 210 220 230 240
TIMNQKFSNI SSEVYFPHNQ AVEWTPHSAN CYVCHSSKPW GKRKSAPQLN PHKMKKRKRG
250 260 270 280 290 300
PEFVKKSKTS SGNSIQWKNM KAFNQMKDSC KKIHLDNNLL VLDYPSDFVK SVSCLVCEHI
310 320 330 340 350 360
LSDPVQTSCK HLFCRICILK YIKLMGCYCP SCKYPCFPTD LTVPVKSYLN VLNALLLKCT
370 380 390 400 410 420
VSGCDEEISL GKYSHHISKH KETKGKEVYA HINKGGRPRQ HLLTLTRRAQ KHRLRELKMQ
430 440 450 460 470 480
VKAFADKEEE GDVKSVCLTL FLLALRARNE HRQADELEAI MEGRGAGLHP AVCLAIRVNT
490 500 510 520 530 540
FLSCSQYHKM YRTVKATTGR QIFQPLHALR NAEKALIPGY HTFEWRPPLK NVSTRTDVGI
550 560 570 580 590 600
IDGLSGLNQS LDEYPVDTIS KRFRYDAALV SALKDMEEDI LEGLKAQDLD DYVSGPFTVV
610 620 630 640 650 660
VKESCDGMGD VSEKHGSGPP VPEKAVRFSF TVMNISVPNK NGPVRIFEET KPNSELCCKP
670 680 690 700 710 720
LCLMLADESD HETLTAILSP LIAEREAMKT AELLLEMGGI LRNFKFSFRG TGYDEKLVRE
730 740 750 760 770 780
VEGLEASGSL YICTLCDATR LEAAQNLVNH SITRSHCENL QRYEMWRSNP HHESPDELRD
790 800 810 820 830 840
RVKGVSAKPF IETLPSIDAL HCDIGNAAEF YRIFQLEIGE LYKNLSATKE EKKRWQATLD
850 860 870 880 890 900
NHIRKRMNLK PIMRMNGNFA RKLMSKETVE AVCELVPCEE RQAALTELMD LYLKMKPVWR
910 920 930 940 950 960
SSCPAKECPE LLCQYSFHSQ RFAELLSTKF KYRYEGKITN YFHKTLAHVP EIIERDGSIG
970 980 990 1000 1010 1020
AWASEGNESG NKLFRRFRKM NARQSKFYEM EDVLKHHWLY TSKYLQKFMN AHNNLKNQGF
1030 1040
TVDLDNPDLE QRLESSMESL ESMEF