Q91819

PR
Gene name
aurka-b (aurka, eg2, stk6)
Protein name
Aurora kinase A-B
Names
Aurora/IPL1-related kinase 1, ARK-1, Aurora-related kinase 1, Serine/threonine-protein kinase 6-B, Serine/threonine-protein kinase Eg2-B, Serine/threonine-protein kinase aurora-A, p46XlEg22
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:398349
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-165 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

280-301 (Activation loop from InterPro)

Target domain

140-390 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q91819

Entry ID Method Resolution Chain Position Source
AF-Q91819-F1 Predicted AlphaFoldDB

No variants for Q91819

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q91819

No associated diseases with Q91819

4 regional properties for Q91819

Type Name Position InterPro Accession
domain Protein kinase domain 140 - 390 IPR000719
active_site Serine/threonine-protein kinase, active site 259 - 271 IPR008271
binding_site Protein kinase, ATP binding site 146 - 169 IPR017441
domain Aurora kinase A 134 - 391 IPR030611

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm, cytoskeleton, spindle pole
  • Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
  • Localizes to the spindle pole during mitosis especially from prophase through anaphase (By similarity)
  • Partially colocalized with gamma tubulin in the centrosome, from S to M phase (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
centrosome A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
spindle microtubule Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole.
spindle pole Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.

6 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
kinesin binding Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation.
microtubule binding Binding to a microtubule, a filament composed of tubulin monomers.
protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

6 GO annotations of biological process

Name Definition
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
meiotic spindle organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a meiotic cell cycle.
mitotic centrosome separation Separation of duplicated centrosome components at the beginning of mitosis. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle.
mitotic spindle assembly Mitotic bipolar spindle assembly begins with spindle microtubule nucleation from the separated spindle pole body, includes spindle elongation during prometaphase, and is complete when all kinetochores are stably attached the spindle, and the spindle assembly checkpoint is satisfied.
peptidyl-serine phosphorylation The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
protein autophosphorylation The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MERAVKENHK PSNVKVFHPM TEGPKRIPVS QPPSTQVRPP VTGVSAQRIL GPSNVPQRVM
70 80 90 100 110 120
MQAQKPVLSN QKPTAQGLLR PATHGHQTSK PQGPNENRNP QQTSHSSTPN MEKKGSTDQG
130 140 150 160 170 180
KTLAVPKEEG KKKQWCLEDF EIGRPLGKGK FGNVYLARER ESKFILALKV LFKSQLEKAG
190 200 210 220 230 240
VEHQLRREVE IQSHLRHPNI LRLYGYFHDA CRVYLILDYA PGGELFRELQ KCTRFDDQRS
250 260 270 280 290 300
ALYIKQLAEA LLYCHSKKVI HRDIKPENLL LGSNGELKIA DFGWSVHAPS SRRTTLCGTL
310 320 330 340 350 360
DYLPPEMIEG RMHDEKVDLW SLGVLCYEFL VGKPPFETDT HQETYRRISK VEFQYPPYVS
370 380 390 400
EEAKDLVSKL LKHNPNHRLP LKGVLEHPWI VKNSQQPKKK DEPLAGAQ