Q91743

PR
Gene name
fgfr4
Protein name
Fibroblast growth factor receptor 4
Names
FGFR-4
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
EC number
2.7.10.1: Protein-tyrosine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

390-506 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

652-677 (Activation loop from InterPro)

Target domain

490-777 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q91743

Entry ID Method Resolution Chain Position Source
AF-Q91743-F1 Predicted AlphaFoldDB

No variants for Q91743

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q91743

No associated diseases with Q91743

16 regional properties for Q91743

Type Name Position InterPro Accession
domain Protein kinase domain 490 - 777 IPR000719
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 491 - 763 IPR001245
domain Immunoglobulin subtype 2 58 - 119 IPR003598-1
domain Immunoglobulin subtype 2 185 - 254 IPR003598-2
domain Immunoglobulin subtype 2 285 - 363 IPR003598-3
domain Immunoglobulin subtype 52 - 129 IPR003599-1
domain Immunoglobulin subtype 179 - 265 IPR003599-2
domain Immunoglobulin subtype 279 - 374 IPR003599-3
domain Immunoglobulin-like domain 33 - 127 IPR007110-1
domain Immunoglobulin-like domain 169 - 259 IPR007110-2
domain Immunoglobulin-like domain 272 - 372 IPR007110-3
active_site Tyrosine-protein kinase, active site 631 - 643 IPR008266
domain Immunoglobulin I-set 183 - 264 IPR013098-1
domain Immunoglobulin I-set 279 - 373 IPR013098-2
binding_site Protein kinase, ATP binding site 496 - 526 IPR017441
domain Tyrosine-protein kinase, catalytic domain 490 - 768 IPR020635

Functions

Description
EC Number 2.7.10.1 Protein-tyrosine kinases
Subcellular Localization
  • Cell membrane ; Single-pass type I membrane protein
  • Endosome
  • Endoplasmic reticulum
  • Internalized from the cell membrane to recycling endosomes, and from there back to the cell membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endosome A vacuole to which materials ingested by endocytosis are delivered.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
fibroblast growth factor receptor activity Combining with a fibroblast growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity.

1 GO annotations of biological process

Name Definition
positive regulation of cell population proliferation Any process that activates or increases the rate or extent of cell proliferation.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSGSIRRSYT AMQNFPRFLL GVLFVATLSS CRPRLSEDEA NWKGQTETSE VEEHLLLDPG
70 80 90 100 110 120
NALRLFCDTN QSSSINWYRE QERLLSGGKI RMVGTVLEVS DVTYEDSGLY ICVVRGTGKI
130 140 150 160 170 180
LRRFSISVVD SLASGDEEEE EEDDDDEDGR REDTTADINE EPVYFFQAPY WTQPSRMDKK
190 200 210 220 230 240
LHAVPAGNTV KFRCPAGGSP LPTIRWSLKN GREFRGEHRI GGIQIRHQHW SLVMESVVPS
250 260 270 280 290 300
DRGNYTCVVE NRVGSLTYTY FLDVLERSSH RPILQAGLPA NTTARVGSDV EFYCKVYSDA
310 320 330 340 350 360
QPHIQWLKHI EVNGSHFGPD DFPYVQVLKT ADINPSDVEV LHLRNITMED AGEYTCLAGN
370 380 390 400 410 420
SIGLSHQSAW LTVLPNEDFL EQAEPAESRY MDIIIYTSGF LAVAMAIMIV ILCRMQTPHS
430 440 450 460 470 480
KQTLQTPTVH KLAKFPLIRQ FSLESSSSGK SSAPLIRITR LSSSCAPMLP GVMEVELPLD
490 500 510 520 530 540
AKWEFPRDRL VLGKPLGEGC FGQVVRAEGY GIEKDRPEKP VTVAVKMLKD NGTDKDLSDL
550 560 570 580 590 600
ISEMELMKVI GKHKNIINLL GVCTQEGPLF VIVEYASKGN LREFLRARRP PTPEDAFDIT
610 620 630 640 650 660
KVPEELLSFK DLVSCAYQVA RGMEYLESKR CIHRDLAARN VLVAEDNVMK IADFGLARGV
670 680 690 700 710 720
HDIDYYKKTS NGRLPVKWMA PEALFDRVYT HQSDIWSFGV LTWEIFTLGG SPYPVIPYEE
730 740 750 760 770 780
LFKLLREGHR MDKPSNCTHE LYMLMRECWH AVPTQRPTFK QLEHLDRILT AVSEEYLDLS
790 800 810 820
MPFEQYSPSC EDSASTCSSS DDSVFAPDPV PSSPCVFNYH NIHSQLGT