Q91738

PR
Gene name
ptk2 (fak1)
Protein name
Focal adhesion kinase 1
Names
FADK 1, Protein-tyrosine kinase 2, pp125FAK
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:399286
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-53 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

576-600 (Activation loop from InterPro)

Target domain

435-693 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q91738

Entry ID Method Resolution Chain Position Source
AF-Q91738-F1 Predicted AlphaFoldDB

No variants for Q91738

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q91738

No associated diseases with Q91738

11 regional properties for Q91738

Type Name Position InterPro Accession
domain FERM domain 35 - 355 IPR000299
domain Protein kinase domain 435 - 693 IPR000719
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 435 - 689 IPR001245
domain Focal adhesion kinase, targeting (FAT) domain 930 - 1061 IPR005189
active_site Tyrosine-protein kinase, active site 555 - 567 IPR008266
binding_site Protein kinase, ATP binding site 441 - 467 IPR017441
domain FERM central domain 136 - 254 IPR019748
domain Band 4.1 domain 31 - 258 IPR019749
domain Tyrosine-protein kinase, catalytic domain 435 - 689 IPR020635
domain Focal adhesion kinase, N-terminal 35 - 130 IPR041390
domain FAK1/PYK2, FERM domain C-lobe 254 - 364 IPR041784

Functions

Description
EC Number
Subcellular Localization
  • Cell junction, focal adhesion
  • Cell membrane; Peripheral membrane protein; Cytoplasmic side
  • Cytoplasm, cytoskeleton, cilium basal body
  • Constituent of focal adhesions
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
ciliary basal body A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
focal adhesion A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ).
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
non-membrane spanning protein tyrosine kinase activity Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein.

4 GO annotations of biological process

Name Definition
positive regulation of cell population proliferation Any process that activates or increases the rate or extent of cell proliferation.
regulation of cellular component organization Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
response to stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism.
signal complex assembly The aggregation, arrangement and bonding together of a set of components to form a complex capable of relaying a signal within a cell.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAAAYLDPNL NHNPSTNAKS RLSTGMERSP GAIERVLRVF HYFESNNEPA TWSSNIRHGD
70 80 90 100 110 120
ATDVRGIIQK IVDSHKVKNV ASYGLRLSHL HSEEVHWLHP DIGVSHIREK YEQSHPPEEW
130 140 150 160 170 180
KYELRIRYLP KGFVNQFTED KPTLNFFYQQ VKNDYMSEIA DQVDQEIALK LGCLEIRRSY
190 200 210 220 230 240
GEMRGNALEK KSNYEVLEKD VGLKRFFPKS LLDSVKAKTL RKLIQQTFRQ FANLNREESI
250 260 270 280 290 300
LKFFEILSPV YRYDKECFKC ALGSSWIISV ELAIGPEEGI SYLTDKGSNP THLADFTQVQ
310 320 330 340 350 360
TIQYSSSEDK DRKGMLQLKI AGAPEPLTVT APSLTIAENM ADLIDGYCRL VSGASESFII
370 380 390 400 410 420
RPQKEGERAL PSIPKLANNE KHGVRPHAVS VSDEFSGDET DDYAEIIDEE DTYTMPSKSY
430 440 450 460 470 480
GLDEAGDYEI QRDRIELGRC IGEGQFGDVH QGVYMSPENP AMAVAIKTCK NCTSDSVREK
490 500 510 520 530 540
FLQEALTMRQ FDHPHIVKLI GVITENPVWI IMELCTLGEL RSFLQVRKYS LDLASLILYS
550 560 570 580 590 600
YQLSTALAYL ESKRFVHRDI AARNVLVSSS DCVKLGDFGL SRYMEDSTYY KASKGKLPIK
610 620 630 640 650 660
WMAPESINFR RFTSASDVWM FGVCMWEILM YGVKPFQGVK NNDVIGRIEN GERLPMPPNC
670 680 690 700 710 720
PPTLYSLMTK CWAYDPSRRP RFTELKAQLS TILEEEKLQQ EERMRMESRR QVTVSWDSGG
730 740 750 760 770 780
SDEAPPKPSR PGYPSPRSSE GFFPSPQHMM QPNHYQVSGF SVAHGIPSMS GNMYPGQASV
790 800 810 820 830 840
LDHMDSWNHR TPDINMWQPS MEDSGPMDMR SLAQVLPTHL MEERLIRQQQ EMEEDQRWLE
850 860 870 880 890 900
KEERFLKPDV RLSRGSVDHV DGNIQCPAGN QHIYQPVGKP DHVAPPKKPP RPGAPSHLGN
910 920 930 940 950 960
LPAHNSPVDG YNEGVKPWRI QPQEISPPPT ANLDRTNDKV YENVTGLVKA VIEMSSRIQP
970 980 990 1000 1010 1020
APPEEYVPMV KGVGLALRTL LATVDETIPV LPASTHREIE MAQKLLNSDL AELINKMKLA
1030 1040 1050 1060
QQYVMTSLQQ EYKKQMLTAA HALAVDAKNL LDVIDQARLK IISHSRPH