Q91727

PR
Gene name
cdk4
Protein name
Cyclin-dependent kinase 4
Names
Cell division protein kinase 4
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:379406
EC number
2.7.11.22: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

260-319 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

157-179 (Activation loop from InterPro)

Target domain

9-295 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q91727

Entry ID Method Resolution Chain Position Source
AF-Q91727-F1 Predicted AlphaFoldDB

No variants for Q91727

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q91727

No associated diseases with Q91727

2 regional properties for Q91727

Type Name Position InterPro Accession
domain ResB-like domain 30 - 292 IPR007816-1
domain ResB-like domain 307 - 444 IPR007816-2

Functions

Description
EC Number 2.7.11.22 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cyclin-dependent protein serine/threonine kinase activity Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.

3 GO annotations of biological process

Name Definition
cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
protein phosphorylation The process of introducing a phosphate group on to a protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSKEMKGQYE PVAEIGVGAY GTVYKARDLQ SGKFVALKNV RVQTNENGLP LSTVREVTLL
70 80 90 100 110 120
KRLEHFDHPN IVKLMDVCAS ARTDRETKVT LVFEHVDQDL KTYLSKVPPP GLPLETIKDL
130 140 150 160 170 180
MKQFLSGLEF LHLNCIVHRD LKPENILVTS GGQVKLADFG LARIYSCQMA LTPVVVTLWY
190 200 210 220 230 240
RAPEVLLQST YATPVDVWSA GCIFAEMFKR KPLFCGNSEA DQLCKIFDII GLPSEEEWPV
250 260 270 280 290 300
DVTLPRSAFS PRTQQPVDKF VPEIDAMGAD LLLAMLTFSP QKRISASDAL LHPFFADDPQ
310
ACSKQEHFTH ICTATDEVK