Q91636

PR
Gene name
kif2c (kcm1)
Protein name
Kinesin-like protein KIF2C
Names
Kinesin central motor 1, xKCM1
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:380006
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

67-144 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q91636

Entry ID Method Resolution Chain Position Source
AF-Q91636-F1 Predicted AlphaFoldDB

No variants for Q91636

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q91636

No associated diseases with Q91636

2 regional properties for Q91636

Type Name Position InterPro Accession
domain Kinesin motor domain 260 - 598 IPR001752
conserved_site Kinesin motor domain, conserved site 490 - 501 IPR019821

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytoskeleton
  • Nucleus
  • Chromosome, centromere
  • Chromosome, centromere, kinetochore
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
kinetochore A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
microtubule plus-end The growing (plus) end of a microtubule. In vitro, microtubules polymerize more quickly at the plus end than at the minus end. In vivo, microtubule growth occurs only at the plus end, and the plus end switches between periods of growth and shortening, a behavior known as dynamic instability.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
microtubule binding Binding to a microtubule, a filament composed of tubulin monomers.
microtubule motor activity A motor activity that generates movement along a microtubule, driven by ATP hydrolysis.

4 GO annotations of biological process

Name Definition
attachment of mitotic spindle microtubules to kinetochore The cell cycle process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex as part of mitotic metaphase plate congression.
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
metaphase plate congression The alignment of chromosomes at the metaphase plate (spindle equator), a plane halfway between the poles of the spindle.
microtubule-based movement A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MERLVATRLV TGLAVKIMRS NGVIHNANIT SVNMDRSSVN VEWKEGEANK GKEISFADVI
70 80 90 100 110 120
SVNPELLDAV LAPTNVKENM PPQRNVSSQN HKRKTISKIP APKEVAAKNS LLSESGAQSV
130 140 150 160 170 180
LRERSTRMTA IHETLPYENE MEAESTPLPI QQNSVQARSR STKVSIAEEP RLQTRISEIV
190 200 210 220 230 240
EESLPSGRNN QGRRKSNIVK EMEKMKNKRE EQRAQNYERR MKRAQDYDTS VPNWEFGKMI
250 260 270 280 290 300
KEFRATMDCH RISMADPAEE HRICVCVRKR PLNKQELSKK EIDIISVPSK NIVLVHEPKL
310 320 330 340 350 360
KVDLTKYLEN QAFRFDFSFD ETATNEVVYR FTARPLVQSI FEGGKATCFA YGQTGSGKTH
370 380 390 400 410 420
TMGGDFSGKS QNVSKGVYAF ASRDVFLLLD QPRYKHLDLD VFVTFFEIYN GKVFDLLNKK
430 440 450 460 470 480
TKLRVLEDAK QEVQVVGLLE KQVISADDVF KMIEIGSACR TSGQTFANTS SSRSHACLQI
490 500 510 520 530 540
ILRRGSKLHG KFSLVDLAGN ERGVDTASAD RITRMEGAEI NRSLLALKEC IRALGQNKSH
550 560 570 580 590 600
TPFRESKLTQ ILRDSFIGEN SRTCMIAMLS PGFNSCEYTL NTLRYADRVK ELSPQNAETN
610 620 630 640 650 660
DDNLQMEDSG GSHASIEGLQ LQDDFLLKDE ELSTHNSFQD ALNRVGELED KAVDELRELV
670 680 690 700 710 720
QKEPEWTNLL QMTEQPDYDL ENFVMQAEYL IQERSKVLIA LGDSINSLRL ALQVEEQASK
QISKKKRSNK