Q91447

PR
Gene name
MAP2K1 (MEK1, PRKMK1)
Protein name
Dual specificity mitogen-activated protein kinase kinase 1
Names
MAP kinase kinase 1, MAPKK 1, ERK activator kinase 1, MAPK/ERK kinase 1, MEK1
Species
Serinus canaria (Island canary) (Fringilla canaria)
KEGG Pathway
EC number
2.7.12.2: Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-87 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

200-221 (Activation loop from InterPro)

Target domain

61-356 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q91447

Entry ID Method Resolution Chain Position Source
AF-Q91447-F1 Predicted AlphaFoldDB

No variants for Q91447

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q91447

No associated diseases with Q91447

3 regional properties for Q91447

Type Name Position InterPro Accession
domain Protein kinase domain 61 - 356 IPR000719
active_site Serine/threonine-protein kinase, active site 179 - 191 IPR008271
binding_site Protein kinase, ATP binding site 67 - 90 IPR017441

Functions

Description
EC Number 2.7.12.2 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
Subcellular Localization
  • Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
  • Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
microtubule organizing center An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
MAP kinase kinase activity Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein tyrosine kinase activity Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
PIQLNPAPDG SAVNGTSSAE TNLEALQKKL EELELDEQQR KRLEAFLTQK QKVGELKDDD
70 80 90 100 110 120
FEKISELGAG NGGVVFKVSH KPSGLIMARK LIHLEIKPAI RNQIIRELQV LHECNSPYIV
130 140 150 160 170 180
GFYGAFYSDG EISICMEHMD GGSLDQVLKK AGRIPEQILG KVSIAVIKGL TYLREKHKIM
190 200 210 220 230 240
HRDVKPSNIL VNSRGEIKLC DFGVSGQLID SMANSFVGTR SYMSPERLQG THYSVQSDIW
250 260 270 280 290 300
SMGLSLVEMA IGRYPIPPPD SKELELMFGC PVEGDSPVTE TSPRQRAPGR PMSSYGSDSR
310 320 330 340 350 360
PPMAIFELLD YIVNEPPPKL PNGVFGSEFQ DFVNKCLIKN PAERADLKQL MIHAFIKRSE
370 380
AEEVDFAGWL CSTIGLNQPS TPTHAAGV