Q91288

PR
Gene name
FGFR4
Protein name
Fibroblast growth factor receptor 4
Names
FGFR-4, PFR4
Species
Pleurodeles waltl (Iberian ribbed newt)
KEGG Pathway
EC number
2.7.10.1: Protein-tyrosine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

108-203 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q91288

Entry ID Method Resolution Chain Position Source
AF-Q91288-F1 Predicted AlphaFoldDB

No variants for Q91288

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q91288

No associated diseases with Q91288

15 regional properties for Q91288

Type Name Position InterPro Accession
domain Protein kinase domain 486 - 774 IPR000719
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 487 - 762 IPR001245
domain Immunoglobulin subtype 2 60 - 121 IPR003598-1
domain Immunoglobulin subtype 2 182 - 250 IPR003598-2
domain Immunoglobulin subtype 2 281 - 359 IPR003598-3
domain Immunoglobulin subtype 54 - 131 IPR003599-1
domain Immunoglobulin subtype 176 - 261 IPR003599-2
domain Immunoglobulin subtype 275 - 370 IPR003599-3
domain Immunoglobulin-like domain 39 - 129 IPR007110-1
domain Immunoglobulin-like domain 157 - 259 IPR007110-2
domain Immunoglobulin-like domain 268 - 368 IPR007110-3
active_site Tyrosine-protein kinase, active site 627 - 639 IPR008266
domain Immunoglobulin I-set 180 - 259 IPR013098
binding_site Protein kinase, ATP binding site 492 - 522 IPR017441
domain Tyrosine-protein kinase, catalytic domain 486 - 762 IPR020635

Functions

Description
EC Number 2.7.10.1 Protein-tyrosine kinases
Subcellular Localization
  • Cell membrane ; Single-pass type I membrane protein
  • Endosome
  • Endoplasmic reticulum
  • Internalized from the cell membrane to recycling endosomes, and from there back to the cell membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endosome A vacuole to which materials ingested by endocytosis are delivered.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
fibroblast growth factor receptor activity Combining with a fibroblast growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity.

1 GO annotations of biological process

Name Definition
positive regulation of cell population proliferation Any process that activates or increases the rate or extent of cell proliferation.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGVQKDSRDI RWNRTTRPLA LLLCGLLAFS ALSCARTLPE GRKANLAELV SEEEEHFLLD
70 80 90 100 110 120
PGNALRLFCD TNQTTIVNWY TESTRLQHGG RIRLTDTVLE IADVTYEDSG LYLCVVPGTG
130 140 150 160 170 180
HILRNFTISV VDSLASGDDD DEDHGREDSA GDMGEDPPYS TSYRAPFWSQ PQRMDKKLYA
190 200 210 220 230 240
VPAGNTVKFR CPSAGNPTPG IRWLKNGREF GGEHRIGGIR LRHQHWSLVM ESVVPSDRGN
250 260 270 280 290 300
YTCLVENKFG SISYSYLLDV LERSPHRPIL QAGLPANTTA MLGSDVQFFC KVYSDAQPHI
310 320 330 340 350 360
QWLKHIEVNG SRYGPDGVPF VQVLKTADIN SSEVEVLYLH NVSFEDAGEY TCLAGNSIGL
370 380 390 400 410 420
SYQSAWLTVL PEEDFAKEAE GPETRYTDII IYTSGSLALL MAAVIVVLCR MQLPPTKTHL
430 440 450 460 470 480
EPATVHKLSR FPLMRQFSLE SSSSGKSSTS LVRVTRLSSS CTPMLPGVLE FDLPLDSKWE
490 500 510 520 530 540
FPRERLVLGK PLGEGCFGQV VRAEAYGINK DQPDKAITVA IKIVKDKGTD KELSDLISEM
550 560 570 580 590 600
ELMKLMGKHK NIINLLGVCT QDGPLYMIVE YASKGNLREF LRARRPPSPD YTFDMTKVPE
610 620 630 640 650 660
EQLSFQDLVS CSYQVARGMA YLESKRCIHR DLAARNVLVT GENVMKIADF GLARGVHDID
670 680 690 700 710 720
YYKKTSNGRL PVKWMAPEAL FDRVYTHQSD VWSFGVLTWE IFTLGGSPYP GIPVEELFKL
730 740 750 760 770 780
LREGHRMDKP SNCTHELYML MRECWHAAPS QRPTFKQLVE TLDRILATVA EEYLDLSMPF
790 800 810 820
EQYSPACEDT TSTCSSDDSV FTHEPDVPSL FTHHTTTSMV GT