Q91287

PR
Gene name
FGFR3
Protein name
Fibroblast growth factor receptor 3
Names
FGFR-3, PFR3
Species
Pleurodeles waltl (Iberian ribbed newt)
KEGG Pathway
EC number
2.7.10.1: Protein-tyrosine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

44-224 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

619-644 (Activation loop from InterPro)

Target domain

457-746 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q91287

Entry ID Method Resolution Chain Position Source
AF-Q91287-F1 Predicted AlphaFoldDB

No variants for Q91287

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q91287

No associated diseases with Q91287

16 regional properties for Q91287

Type Name Position InterPro Accession
domain Protein kinase domain 457 - 746 IPR000719
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 457 - 733 IPR001245
domain Immunoglobulin subtype 2 47 - 109 IPR003598-1
domain Immunoglobulin subtype 2 156 - 224 IPR003598-2
domain Immunoglobulin subtype 2 255 - 335 IPR003598-3
domain Immunoglobulin subtype 41 - 119 IPR003599-1
domain Immunoglobulin subtype 150 - 235 IPR003599-2
domain Immunoglobulin subtype 249 - 346 IPR003599-3
domain Immunoglobulin-like domain 29 - 119 IPR007110-1
domain Immunoglobulin-like domain 140 - 233 IPR007110-2
domain Immunoglobulin-like domain 239 - 344 IPR007110-3
active_site Tyrosine-protein kinase, active site 598 - 610 IPR008266
domain Immunoglobulin I-set 155 - 234 IPR013098-1
domain Immunoglobulin I-set 251 - 345 IPR013098-2
binding_site Protein kinase, ATP binding site 463 - 493 IPR017441
domain Tyrosine-protein kinase, catalytic domain 457 - 733 IPR020635

Functions

Description
EC Number 2.7.10.1 Protein-tyrosine kinases
Subcellular Localization
  • Cell membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
fibroblast growth factor receptor activity Combining with a fibroblast growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity.

2 GO annotations of biological process

Name Definition
apoptotic process A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
positive regulation of cell population proliferation Any process that activates or increases the rate or extent of cell proliferation.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLVWLCGLCL VTLAGGRSAA RLPLTEGRPT ADFLPGDASL VEELLFGTGD TIELSCTTPG
70 80 90 100 110 120
SSVSVVWFKD GISVDPPTWS HTGQKLLKII NVSYDDSGVY SCKARQSSEV LRNVTVRVTD
130 140 150 160 170 180
SPSSGDDEDD DEESESANAP KFTRPEWMEK KLLAVPAANT VRFRCPAAGK PTPSITWLKN
190 200 210 220 230 240
GKEFKGEHRI GGIKLRHQQW SLVMESVVPS DRGNYTCVVA NKYGTIRETY TLDVLERTPH
250 260 270 280 290 300
RPILQAGFRS NKTVVVGSDV EFHCKVYSDA QPHIQWLKHV EVNGSKFGPD GNPYVTVLKT
310 320 330 340 350 360
AGVNTSDKEL EIQFLRNVTF EDAGEYTCLA GNSIGYSHHS AWLTVLPPAE PVPDVDTSVS
370 380 390 400 410 420
ILAAAGCVAV VILVVIIIFT YKMKMPSKKT MNTATVHKVS KFPLKRQVSL ESNSSMNSNT
430 440 450 460 470 480
PLVRITRLSS SDGPMLANVS ELELPADPKW ELSRSRLTLG KPLGEGCFGQ VVMADAVGIE
490 500 510 520 530 540
KDKPNKATSV AVKMLKDDAT DKDLSDLVSE MEMMKMIGKH KNIINLLGAC TQDGPLYVLV
550 560 570 580 590 600
EYASKGNLRE YLRARRPPGM DYSFDTCKLP EEQLTFKDLV SCAYQVARGM EYLASQKCIH
610 620 630 640 650 660
RDLAARNVLV TDDNVMKIAD FGLARDVHNI DYYKKTTNGR LPVKWMAPEA LFDRVYTHQS
670 680 690 700 710 720
DVWSFGVLLW EIFTLGGSPY PGIPVEELFK LLKEGHRMDK PANCTHELYM IMRECWHAVP
730 740 750 760 770 780
SQRPTFKQLV EDLDRVLTVT STDEYLDLSV PFEQYSPACP DSHSSCSSGD DSVFAHDLPE
790
EPCLPKHQQY NGVIRT