Q91285

PR
Gene name
FGFR1
Protein name
Fibroblast growth factor receptor 1
Names
FGFR-1, PFR1
Species
Pleurodeles waltl (Iberian ribbed newt)
KEGG Pathway
EC number
2.7.10.1: Protein-tyrosine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-234 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

636-661 (Activation loop from InterPro)

Target domain

460-761 (Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q91285

Entry ID Method Resolution Chain Position Source
AF-Q91285-F1 Predicted AlphaFoldDB

No variants for Q91285

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q91285

No associated diseases with Q91285

17 regional properties for Q91285

Type Name Position InterPro Accession
domain Protein kinase domain 474 - 763 IPR000719
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 475 - 750 IPR001245
domain Immunoglobulin subtype 2 45 - 107 IPR003598-1
domain Immunoglobulin subtype 2 167 - 235 IPR003598-2
domain Immunoglobulin subtype 2 266 - 346 IPR003598-3
domain Immunoglobulin subtype 39 - 118 IPR003599-1
domain Immunoglobulin subtype 161 - 246 IPR003599-2
domain Immunoglobulin subtype 260 - 357 IPR003599-3
domain Immunoglobulin-like domain 33 - 118 IPR007110-1
domain Immunoglobulin-like domain 156 - 244 IPR007110-2
domain Immunoglobulin-like domain 253 - 355 IPR007110-3
active_site Tyrosine-protein kinase, active site 615 - 627 IPR008266
domain Immunoglobulin I-set 167 - 245 IPR013098
domain Immunoglobulin 41 - 114 IPR013151
binding_site Protein kinase, ATP binding site 480 - 510 IPR017441
domain Tyrosine-protein kinase, catalytic domain 474 - 750 IPR020635
domain Fibroblast growth factor receptor 1, catalytic domain 460 - 761 IPR028174

Functions

Description
EC Number 2.7.10.1 Protein-tyrosine kinases
Subcellular Localization
  • Cell membrane ; Single-pass type I membrane protein
  • Nucleus
  • Cytoplasm, cytosol
  • Cytoplasmic vesicle
  • After ligand binding, both receptor and ligand are rapidly internalized
  • Can translocate to the nucleus after internalization, or by translocation from the endoplasmic reticulum or Golgi apparatus to the cytosol, and from there to the nucleus (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytoplasmic vesicle A vesicle found in the cytoplasm of a cell.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
fibroblast growth factor receptor activity Combining with a fibroblast growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity.

1 GO annotations of biological process

Name Definition
positive regulation of cell population proliferation Any process that activates or increases the rate or extent of cell proliferation.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLSWRHLVFW AMLVMATLSA ARPAPTLPEQ VSPKAKVEVE SYSAHHGDLL QLRCRLRDDV
70 80 90 100 110 120
HSINWEKDGV QLAETNRTRI TGAEVEVRDA VQEDSGLYAC MTHRPSGTET TFFAVNVSDR
130 140 150 160 170 180
IPSVEDDDDD DEKSSSEEKE AENSKPNPVA PFWAHPEKME KKLHAVPAAK TVKFRCPAGG
190 200 210 220 230 240
TPSPTLRWLK NGKEFKPDHR IGGYKVRYQT WSIIMDSVVP SDKGPYTCLV ENNYGSINHT
250 260 270 280 290 300
YQLDVVERSP HRPILQAGLP ANQTVPVGSN VDFVCKVYSD PQPHIQWLKH VTVNGSKYGS
310 320 330 340 350 360
DGLPLVQVLK AAGVNTTDKE MEVLHLRNVS FEDAWEYTCL AGNSIGISHH SAWLTVVEAI
370 380 390 400 410 420
SENPVIMTSP LYLEIIIYCT GAFLISCMLV TVIIYKMKNT TKKTDFNSQP AVHKLAKSFP
430 440 450 460 470 480
LQRQVSADSS SSMSSGVMLV RPSRLSSSGS PMLTGVSEYE LPEDPRWEFS RDRLILGKPL
490 500 510 520 530 540
GEGCFGQVVM GEAIGLDKEK PNRVTKVAVK MLKSDATEKD LSDLISEMEM MKMIGKHKNI
550 560 570 580 590 600
INLLGACTQD GPLYVIVEYA SKGNLREYLR ARRPPGMEYC YNPIHVSKDM LSFKDLVSCA
610 620 630 640 650 660
YQVARGMEYL ASKKCIHRDL AARNVLVTED SVMKIADFGL ARDIHHIDYY KKTTNGRLPV
670 680 690 700 710 720
KWMAPEALFD RIYTHQSDVW SFGVLLWEIF TLGGSPYPGV PVEELFKLLK EGHRMDKPGN
730 740 750 760 770 780
CTNELYMMMR DCWHAVPSQR PTFKQLVEDL DRIVAMTSNQ EYLDLSMPVD QYSPGFPDTR
790 800 810
SSTCSSGEDS VFSHDPLPDE PCLPKYQHAN GGLKKR