Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q91175
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q91175-F1 | Predicted | AlphaFoldDB |
No variants for Q91175
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q91175 | |||||
No associated diseases with Q91175
1 regional properties for Q91175
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | GPCR, rhodopsin-like, 7TM | 43 - 324 | IPR017452 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| alpha1-adrenergic receptor activity | Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha1-adrenergic receptors; the activity involves transmitting the signal to the Gq alpha subunit of a heterotrimeric G protein. |
| G protein-coupled receptor activity | Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| adenylate cyclase-activating adrenergic receptor signaling pathway | An adenylate cyclase-activating G protein-coupled receptor signaling pathway initiated by a ligand binding to an adrenergic receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process. |
| cell-cell signaling | Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions. |
| phospholipase C-activating G protein-coupled receptor signaling pathway | A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase C (PLC) and a subsequent increase in the intracellular concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG). |
| positive regulation of cytosolic calcium ion concentration | Any process that increases the concentration of calcium ions in the cytosol. |
| positive regulation of heart rate by epinephrine-norepinephrine | The process in which the presence of epinephrine or norepinephrine in the bloodstream activates, maintains or increases the rate of heart contraction. |
| positive regulation of MAPK cascade | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade. |
| positive regulation of vasoconstriction | Any process that activates or increases the frequency, rate or extent of vasoconstriction. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTPSSVTLNC | SNCSHVLAPE | LNTVKAVVLG | MVLGIFILFG | VIGNILVILS | VVCHRHLQTV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TYYFIVNLAV | ADLLLSSTVL | PFSAIFEILD | RWVFGRVFCN | IWAAVDVLCC | TASIMSLCVI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SVDRYIGVSY | PLRYPAIMTK | RRALLAVMLL | WVLSVIISIG | PLFGWKEPAP | EDETVCKITE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EPGYAIFSAV | GSFYLPLAII | LAMYCRVYVV | AQKESRGLKE | GQKIEKSDSE | QVILRMHRGN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TTVSEDEALR | SRTHFALRLL | KFSREKKAAK | TLGIVVGCFV | LCWLPFFLVL | PIGSIFPAYR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PSDTVFKITF | WLGYFNSCIN | PIIYLCSNQE | FKKAFQSLLG | VHCLRMTPRA | HHHHLSVGQS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QTQGHSLTIS | LDSKGAPCRL | SPSSSVALSR | TPSSRDSREW | RVFSGGPINS | GPGPTEAGRA |
| 430 | 440 | 450 | 460 | ||
| KVAKLCNKSL | HRTCCCILRA | RTPTQDPAPL | GDLPTIKIHQ | LSLSEKGESV |