Q91147

PR
Gene name
FGFR2
Protein name
Fibroblast growth factor receptor 2
Names
FGFR-2
Species
Notophthalmus viridescens (Eastern newt) (Triturus viridescens)
KEGG Pathway
EC number
2.7.10.1: Protein-tyrosine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-145 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q91147

Entry ID Method Resolution Chain Position Source
AF-Q91147-F1 Predicted AlphaFoldDB

No variants for Q91147

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q91147

No associated diseases with Q91147

13 regional properties for Q91147

Type Name Position InterPro Accession
domain Protein kinase domain 389 - 678 IPR000719
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 389 - 665 IPR001245
domain Immunoglobulin subtype 2 80 - 148 IPR003598-1
domain Immunoglobulin subtype 2 179 - 259 IPR003598-2
domain Immunoglobulin subtype 74 - 159 IPR003599-1
domain Immunoglobulin subtype 173 - 270 IPR003599-2
domain Immunoglobulin-like domain 64 - 157 IPR007110-1
domain Immunoglobulin-like domain 166 - 268 IPR007110-2
active_site Tyrosine-protein kinase, active site 530 - 542 IPR008266
domain Immunoglobulin I-set 81 - 158 IPR013098-1
domain Immunoglobulin I-set 173 - 269 IPR013098-2
binding_site Protein kinase, ATP binding site 395 - 425 IPR017441
domain Tyrosine-protein kinase, catalytic domain 389 - 665 IPR020635

Functions

Description
EC Number 2.7.10.1 Protein-tyrosine kinases
Subcellular Localization
  • Cell membrane; Single-pass type I membrane protein
  • Golgi apparatus
  • Cytoplasmic vesicle
  • Detected on osteoblast plasma membrane lipid rafts
  • After ligand binding, the activated receptor is rapidly internalized and degraded (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasmic vesicle A vesicle found in the cytoplasm of a cell.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
fibroblast growth factor receptor activity Combining with a fibroblast growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity.

2 GO annotations of biological process

Name Definition
apoptotic process A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
positive regulation of cell population proliferation Any process that activates or increases the rate or extent of cell proliferation.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MFSWSYLMGL VMVATATLSL ARPSYNIAED TTLEPEDANS SGDDEDDNDG SEDFTNDNNH
70 80 90 100 110 120
MRAPYWTNTE KLEKKLHAVP AANTVKFRCP AGGNPTPSMR WLKNGKEFKQ EHRIGGFKVR
130 140 150 160 170 180
SQHFSLIMES VVPSDEGNYT CIMENEYGSI NHTYHLDVVE RSPHRPILQA GLPANTTTKV
190 200 210 220 230 240
GGDAEFVCKV YSDAQPHIQW IRHFELNGSK IGPDGHPYLK VLKAAGVNTT DKEIEVLYVR
250 260 270 280 290 300
NVSFEDAGEY TCLAGNSTGI SYHTAWLTVL PDEERELDSS SEYTEIAIYC VGGFLITCMI
310 320 330 340 350 360
GTIMVCHMKG RGKKSDFSSP PAVHKLSKSL PLRRQVTVSA DSSSSMNSNT PLVRITTRLS
370 380 390 400 410 420
SNNDTHLLAG VSEYELPEDP KWEYPREKLT LGKPLGEGCF GQVVMAEAVG IDKDRPKDAA
430 440 450 460 470 480
TVAVKMLKDD ATEKDLSDLV SEMEMMKMIG KHKNIINLLG ACTQDGPLYV IVEYASKGNL
490 500 510 520 530 540
REYLRTRRPP GMEYSFDINR IPEEQMTFKD LVSCTYQLAR GMEYLASQKC IHRDLAARNV
550 560 570 580 590 600
LVTETNVMKI ADFGLARDIN NIDYYKKTTN GRLPVKWMAP EALFDRVYTH QSDVWSFGVL
610 620 630 640 650 660
MWEIFTLGGS PYPGIPVEEL FKLLKEGHRM DKPGNCTNEL YTMMTDCWRA VPSQRPTFKQ
670 680 690 700 710 720
LVEDLDRILT QTTNEEYLDL NNPLEQYSPS YPDTRSSCSS GDDSVFSPDA MPYDPCLPKS
QHTNGTIKT