Q90ZY4

PR
Gene name
sbk1 (bsk146)
Protein name
Serine/threonine-protein kinase SBK1
Names
Brain-specific protein kinase BSK146, SH3-binding kinase 1
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:405767
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

286-385 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

172-192 (Activation loop from InterPro)

Target domain

32-297 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q90ZY4

Entry ID Method Resolution Chain Position Source
AF-Q90ZY4-F1 Predicted AlphaFoldDB

No variants for Q90ZY4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q90ZY4

No associated diseases with Q90ZY4

9 regional properties for Q90ZY4

Type Name Position InterPro Accession
repeat WD40 repeat 360 - 479 IPR001680-1
repeat WD40 repeat 479 - 700 IPR001680-2
domain F-box domain 195 - 242 IPR001810
conserved_site WD40 repeat, conserved site 384 - 398 IPR019775-1
conserved_site WD40 repeat, conserved site 464 - 478 IPR019775-2
conserved_site WD40 repeat, conserved site 505 - 519 IPR019775-3
repeat G-protein beta WD-40 repeat 384 - 398 IPR020472-1
repeat G-protein beta WD-40 repeat 464 - 478 IPR020472-2
repeat G-protein beta WD-40 repeat 644 - 658 IPR020472-3

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

2 GO annotations of biological process

Name Definition
peptidyl-serine phosphorylation The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
peptidyl-threonine phosphorylation The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSSSPVVSRD ILEELQLYTA QNLEKLEVNK YYEVIRELGK GTYGKVDLVI HKIRGSKMAL
70 80 90 100 110 120
KFLKKKSTKL KSFLREYSIS LYLSPCPFII NMFGIAFETD EYYVFAQEYA PSGDLFDIIP
130 140 150 160 170 180
PQVGLPEPVA KRCVHQVAIA LEYLHSKKLV HRDIKPENIL IFDKECRKVK LSDFGMTRRA
190 200 210 220 230 240
GSPVKRVSGT IPYTAPELCD TSKHDGFCVD YSTDVWAFGV LLFCMLTGNF PWEKAMPSDT
250 260 270 280 290 300
FYEEFVRWQK RRTGAVPSQW RRFTDESLRM FRKLLALEQE RRCSVKEVFA HLGHRWMLDG
310 320 330 340 350 360
TSGNHHQSVL NSSSEEDELL VDRMKQQTLS PTANTSNAIE PGSANHFTSM STNSSVSSTN
370 380
SYERSARDSP PTSRILVTTP IEICV