Q90WN7

PR
Gene name
sycp2l (no145)
Protein name
Synaptonemal complex protein 2-like
Names
SCP-2-like, 145 kDa nucleolar protein
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:398239
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

400-858 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q90WN7

Entry ID Method Resolution Chain Position Source
AF-Q90WN7-F1 Predicted AlphaFoldDB

No variants for Q90WN7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q90WN7

No associated diseases with Q90WN7

2 regional properties for Q90WN7

Type Name Position InterPro Accession
domain Synaptonemal complex protein 2, Spt16M-like domain 282 - 392 IPR040560
domain Synaptonemal complex protein 2, armadillo-repeat-like domain 19 - 190 IPR041322

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Chromosome, centromere
  • Nucleus, nucleolus
  • Localized to the synaptonemal complex lateral elements in late diplotene oocytes, while it is absent on the synaptonemal complex of leptotene, zygotene, pachytene and early diplotene oocytes
  • Localizes to centromeres in dictyate oocytes (By similarity)
  • Detected in nuclear granules and sizable aggregates (By similarity)
  • Localized in a cage-like cortical structure around the entire nucleolus, consisting of a meshwork of patches and filaments
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
chromosome, centromeric region The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSEDGAQTAE KMDTHTQYYL ESLIIDALKG KGFQKIIELF DGKVIFSSQF HNKLLLSQLD
70 80 90 100 110 120
KLINKELDRN EFKHVSVLMK CIQHFCKNDC QESSTLIHQG LVSKMVLWFE RTVDFLRISK
130 140 150 160 170 180
EATLLTLVED FYDSALVICK CNCEDGKRQL LDSFLIRLGH LVTEKWVACH LRLEALRTIN
190 200 210 220 230 240
CILDSISRED KKKLHCSEDL CELTKDLART IQEAGDYDIQ VAISEALCRM MGKKFRDSFV
250 260 270 280 290 300
HQWFEDNFLA DAFKEIKDKE FETDCRKFLN CLNSRHQSNK GVYTFPCITV FTDLDELKKP
310 320 330 340 350 360
QDENMENFWI DFNAGSQCVS FYIHNTEGSL WDSVRLLKES VNNYTLKEND GQQMLGIYLK
370 380 390 400 410 420
DPQVINTNDV TKVKIYFEPK HDIKSAIKRV FEDINEIHSN PVELDSTEGL IDIGNSLASH
430 440 450 460 470 480
TVITTATTFK QWKRNQANKM DSASDILGSQ TSEHSSTTKT SSANRSVQKS LSNADSHEIV
490 500 510 520 530 540
IESVPLEAVI TIADEQPNTA QFQDDMDDAI FQGAASDVPA KDSSQEIIII TEASADKEFA
550 560 570 580 590 600
AKKTQGIFQF QGYSDTLASD QVSDAKKKIL LPKQSTERAT PASRYRASMN SPLQRTSSAY
610 620 630 640 650 660
RSHLFCESNE VTSNTESERS WIQDFKNKSA VKSADYSCEK TRNKSKRKVL PLASESGDDE
670 680 690 700 710 720
KQVDTTETVA RFTSRKEMHR PEDINPKSPH SAELKLPGIS ALLTPGDSRS QSKSDYRYQS
730 740 750 760 770 780
AIDDQDIMDP VEEASSPEMS IDHNKEPKNG HDEVYASGPL NRSVDGNNIY HAADTLQHAT
790 800 810 820 830 840
GKRKHKTCER EEIPFKPRKL FSSTEKNVNR SAADSEDSED VFYSESHDQD LAEASVLSAF
850 860 870 880 890 900
DSFTKELKRK FLTRYKRIEN RANHVLKSSH QQVSTVLNEI HQCRLQKINH FNKIVVHELS
910 920 930 940 950 960
SLEAEVQALK QFEKETLDFW EDQYVKMNTF CSSQTQRIKT MDSALLETIS NLKNVIQKTT
970
KEEVSNTEEH IQNKLLK