Q90330

PR
Gene name
FGFR4 (FREK)
Protein name
Fibroblast growth factor receptor 4
Names
FGFR-4, Fibroblast growth factor receptor-like embryonic kinase
Species
Coturnix coturnix (Common quail) (Tetrao coturnix)
KEGG Pathway
EC number
2.7.10.1: Protein-tyrosine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-139 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

541-566 (Activation loop from InterPro)

Target domain

379-667 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q90330

Entry ID Method Resolution Chain Position Source
AF-Q90330-F1 Predicted AlphaFoldDB

No variants for Q90330

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q90330

No associated diseases with Q90330

1 regional properties for Q90330

Type Name Position InterPro Accession
domain UBX domain 424 - 570 IPR001012

Functions

Description
EC Number 2.7.10.1 Protein-tyrosine kinases
Subcellular Localization
  • Cell membrane ; Single-pass type I membrane protein
  • Endosome
  • Endoplasmic reticulum
  • Internalized from the cell membrane to recycling endosomes, and from there back to the cell membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endosome A vacuole to which materials ingested by endocytosis are delivered.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
fibroblast growth factor receptor activity Combining with a fibroblast growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity.

1 GO annotations of biological process

Name Definition
positive regulation of cell population proliferation Any process that activates or increases the rate or extent of cell proliferation.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLPLWLVLAG LLLAVGPAAS HRGEMEPDSL ASGDDDEDSD GDGPHGDRSE EPVYMHRAPY
70 80 90 100 110 120
WTHPHRMDKK LYAVPAGNTV KFRCPASGSP SPSIRWFKNG REFRGEHRIG GIRLRHQHWS
130 140 150 160 170 180
LVMESVVPSD RGNYTCLVEN RFGRIRYSYL LDVLERSPHR PILQAGLPAN TTALVGSDVE
190 200 210 220 230 240
FFCKVYSDAQ PHLQWLKHIE VNGSSYGPDG VPYVQVLKTA DINSSEVEVL YLRNVTMEDA
250 260 270 280 290 300
GEYTCLAGNS IGLSYQSAWL TVLPEEELVH EAETSEAKYT DIIIYTSGSL AVAMALIIVV
310 320 330 340 350 360
LCRMQTQSSK QPLEPMAVHK LSKFPLIRQF SLDSSSSGKS STSLMRVTRL SSSCAPMLAG
370 380 390 400 410 420
VVEMDLPLDS KWEFPREKLV LGKPLGEGCF GQVVRAEAYG IDRQWPDRAV TVAVKMLKDN
430 440 450 460 470 480
ATDKDLADLI SEMEMMKLMD KHKNIINLLG VCTQDGPLYV IVEFAAKGNL REYLRARRPP
490 500 510 520 530 540
TPDYTFDITE LHEEQLCFKD LVSCVYQVAR GMEYLESRRC IHRDLAARNV LVTAENVMKI
550 560 570 580 590 600
ADFGLARDVH DIDYYKKTSN GRLPVKWMAP EALFDRVYTH QSDVWSFGIL MWEIFTLGGS
610 620 630 640 650 660
PYPGIPVEEL FKLLKEGHRM DCPSNCTHEL YMLMRECWHA VPLQRPTFKQ LVEGLDKILA
670 680 690 700 710
AISEEYLDLS MPFEQYSPSC EDTTSTCSSD DSVFTHDPMP LAPCLFSCPS GRT