Q90321

PR
Gene name
map2k2 (mkk)
Protein name
Dual specificity mitogen-activated protein kinase kinase 2
Names
MAP kinase kinase 2, MAPKK 2, ERK activator kinase 2, MAPK/ERK kinase 2, MEK2
Species
Cyprinus carpio (Common carp)
KEGG Pathway
EC number
2.7.12.2: Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-89 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

208-229 (Activation loop from InterPro)

Target domain

69-366 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q90321

Entry ID Method Resolution Chain Position Source
AF-Q90321-F1 Predicted AlphaFoldDB

No variants for Q90321

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q90321

No associated diseases with Q90321

6 regional properties for Q90321

Type Name Position InterPro Accession
domain Translational (tr)-type GTP-binding domain 407 - 576 IPR000795
domain Small GTP-binding protein domain 410 - 566 IPR005225
domain Translation initiation factor IF-2, N-terminal 331 - 381 IPR006847
domain Initiation factor 2 associated domain, bacterial 60 - 98 IPR013575
domain Translation initiation factor IF- 2, domain 3 683 - 797 IPR023115
domain Translation initiation factor IF-2, domain II 582 - 676 IPR044145

Functions

Description
EC Number 2.7.12.2 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
MAP kinase kinase activity Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein tyrosine kinase activity Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAPKRRPVPL IIAPTGEGQS TNIDAASEAN LEALQRKLGE LDLDEQQRKR LEAFLTQKAQ
70 80 90 100 110 120
VGELKDEDFD PICELGAGNG GVVHKVRHKP SRLVMARKLI HLEIKPAIRN QIIRELQVLH
130 140 150 160 170 180
ECNSPYIVGF YGAFYSDGEI SICMEHMDGG SLDQVLKEAR RIPEEILGKV SIAVLRGLVY
190 200 210 220 230 240
LREKHQIMHR DVKPSNILVN SRGEIKLCDF GVSGQLIDSM ANSFVGTRSY MSPERLQGTH
250 260 270 280 290 300
YSVQSDVWSM GLSLVELAIG RFPIPPPDAK ELEAIFGRPV LDKGGAEGHS MSPRQRPPGR
310 320 330 340 350 360
PVSGHGMDSR PAMAIFELLD YIVNEPPPKL PHGVFTTDFE EFVMKCLMKN PADRADLKML
370 380 390
MGHTFIKRAE VEEVDFAGWM CKTMGLPQPS TPTHSAE